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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Intrauterine Device Clear all
Completed No phase listed Observational Accepts healthy volunteers

Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement

NCT01496898
View directory record Official record
Conditions
Human Microbiome, Metagenome, Contraception, Cytokine
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 23, 2026, 7:14 PM EDT
Completed No phase listed Observational

Expulsion of Immediate Postplacental Copper Intrauterine Devices at Six Months: A Prospective Cohort Study

NCT02706340
View directory record Official record
Conditions
Postpartum, Intrauterine Devices, Copper
Interventions
No intervention - observational study only
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
309 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Sep 23, 2026, 7:14 PM EDT
Terminated Not applicable Interventional

Intrauterine Device (IUD) Self Removal

NCT05191238
View directory record Official record
Conditions
IUD Removal
Interventions
IUD self-removal education
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Phase 4 Interventional Results available

RAPID EC - Rct Assessing Pregnancy With Intrauterine Devices for EC

NCT02175030
View directory record Official record
Conditions
Contraception
Interventions
Copper IUD, Levonorgestrel IUD
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
711 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
6
States / cities
Logan, Utah • Ogden, Utah • Orem, Utah + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Phase 2 Interventional Results available

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

NCT02035787
View directory record Official record
Conditions
Complex Atypical Hyperplasia, Endometrial Cancer
Interventions
Metformin
Drug
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 23, 2026, 7:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Postplacental Insertion of Levonorgestrel-releasing Intrauterine System (LNG-IUS) After Cesarean vs. Interval Insertion

NCT00635362
View directory record Official record
Conditions
Healthy
Interventions
Levonorgestrel-releasing intrauterine system (LNG-IUS)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office

NCT05068245
View directory record Official record
Conditions
Pain, Acute, Anxiety
Interventions
Preselected classical music
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older · Female only
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Copper Intrauterine Device (IUD) Insertion at Cesarean Delivery

NCT01439802
View directory record Official record
Conditions
Intrauterine Device Expulsion
Interventions
Copper IUD placement at time Cesarean Delivery (Copper T 380A)
Device
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion

NCT02391714
View directory record Official record
Conditions
Contraception
Interventions
IUD insertion, Povidone-Iodine, Chlorhexidine, Oxygen, Nitrous oxide
Procedure · Drug · Other
Lead sponsor
University of New Mexico
Other
Eligibility
12 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 2, 2016 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women

NCT01534520
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 21, 2016 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Postplacental or Delayed Insertion of the Levonorgestrel-releasing Intrauterine Device (IUD) After Vaginal Delivery

NCT00476021
View directory record Official record
Conditions
Contraception
Interventions
Levonorgestrel-releasing IUD (Mirena)
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2016 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A RCT of Ultrasound Guided IUD Insertion

NCT03493815
View directory record Official record
Conditions
IUD Not Visible
Interventions
Transabdominal Ultrasound Guided IUD Insertion, Traditional Blind IUD Insertion
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional

Effect of an Intrauterine Contraceptive Device (IUD) in HIV Infected Women

NCT00096694
View directory record Official record
Conditions
HIV Infections
Interventions
Levonorgestrel-releasing intrauterine device (IUD)
Device
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2005
U.S. locations
8
States / cities
Los Angeles, California • Baltimore, Maryland • Fall River, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 23, 2026, 7:14 PM EDT
Completed No phase listed Observational Results available

Patient Factors Associated With Fragmentation of Copper Intrauterine Device (IUD) Requiring Hysteroscopic Removal

NCT07351084
View directory record Official record
Conditions
Intrauterine Device Complications, Contraceptive Device Failure, IUD Fragmentation, Retained Intrauterine Device, Female Contraception, Women's Health, Reproductive Health
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
44 participants
Timeline
2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 23, 2026, 7:14 PM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Weighted Blankets for IUD Insertion

NCT06969365
View directory record Official record
Conditions
Intra-uterine Device Placement
Interventions
10-pound weighted lap-pad, blanket
Other
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 23, 2026, 7:14 PM EDT
Recruiting Phase 2 Interventional

A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia

NCT07107334
View directory record Official record
Conditions
Endometrioid Endometrial Adenocarcinoma
Interventions
Glucagon-like peptide 1 receptor agonist
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pain Control for Intrauterine Device Placement Using Paracervical Block

NCT02219308
View directory record Official record
Conditions
Pain Due to Intrauterine Contraceptive Device
Interventions
Paracervical Block (PCB), No Paracervical Block (Sham PCB)
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 23, 2026, 7:14 PM EDT
Withdrawn Phase 2 Interventional

IUD and Norethindrone Acetate for Treatment of Endometriosis

NCT04948489
View directory record Official record
Conditions
Endometriosis
Interventions
norethindrone acetate (NETA), Placebo
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
13 Years to 24 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 23, 2026, 7:14 PM EDT
Not yet recruiting Phase 2 Interventional

A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

NCT07349641
View directory record Official record
Conditions
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
Interventions
Medical Device Usage and Evaluation, Tirzepatide
Other · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Chicago, Illinois • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 23, 2026, 7:14 PM EDT
Not yet recruiting Not applicable Interventional

Effect of Periumbilical Vibration on Pain Perception During Intrauterine Device Insertion: A Randomized Controlled Trial

NCT07714590
View directory record Official record
Conditions
Intrauterine Device Placement
Interventions
Periumbilical Vibration during Intrauterine Device Placement
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 23, 2026, 7:14 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Early Postpartum Intrauterine Device (IUD) Placement

NCT01594476
View directory record Official record
Conditions
Contraception
Interventions
Levonorgestrel IUS
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Suction Cervical Stabilizer Compared to Standard Tenaculum for Intrauterine Procedures

NCT06193590
View directory record Official record
Conditions
Intrauterine Device (IUD), Abnormal Uterine Bleeding
Interventions
Carevix, Tenaculum
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 23, 2026, 7:14 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain

NCT01967017
View directory record Official record
Conditions
IUD Insertion Complication, Pain Control
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Sep 23, 2026, 7:14 PM EDT
Completed Not applicable Interventional

Cold Compress for Pain Associated With Intrauterine Device Insertion

NCT02898831
View directory record Official record
Conditions
Intrauterine Device, Cold Compress
Interventions
Cold Compress
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 23, 2026, 7:14 PM EDT