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Showing 1–24 of 107 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Isolation, Social Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Protective Effect of Friendship on Peer Rejection in Overweight and Normal Weight Youth

NCT01324661
View directory record Official record
Conditions
Social Exclusion, Control
Interventions
Ostracism
Behavioral
Lead sponsor
University at Buffalo
Other
Eligibility
12 Years to 14 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
View directory record Official record
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positive Affect Regulation sKills at Northwestern University

NCT04367922
View directory record Official record
Conditions
Anxiety, Depression, Social Isolation
Interventions
Positive Emotion Skills Course
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Jul 24, 2026, 9:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatology

NCT04440098
View directory record Official record
Conditions
Loneliness, Depression, Anxiety, Alcohol Abuse, Drug Abuse
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 35 Years
Enrollment
1,008 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional

Qnnections: Refinement and Pilot Trial of a Suicide Prevention Intervention to Increase Social Connection

NCT06803329
View directory record Official record
Conditions
Suicidal Thoughts and Behaviors, Social Isolation
Interventions
Qnnections, Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Blue Star Cares: Innovative Approaches to Helping Military-Connected Caregivers

NCT03336190
View directory record Official record
Conditions
Military Family, Mental Health Disorder, Social Skills, Social Isolation, Communication, Quality of Life
Interventions
avatar-based training
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Jul 24, 2026, 9:16 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effect of a Telephone Reminiscence Intervention on Mental Health

NCT07576855
View directory record Official record
Conditions
Mental Health
Interventions
Telephone Reminiscence Program
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Health Behavior System

NCT03538158
View directory record Official record
Conditions
Social Isolation, Aging, Physical Activity
Interventions
Intervention Condition, Control Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional

Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)

NCT06584422
View directory record Official record
Conditions
Depression
Interventions
Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional

Fostering Agricultural Relationships and Meaning - Thriving on Kinship

NCT07218965
View directory record Official record
Conditions
Loneliness, Social Isolation, Rural Health
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional

Improving the Health and Social Participation of People With Disabilities From Underrepresented Groups Post COVID

NCT05792852
View directory record Official record
Conditions
Disabilities Multiple
Interventions
ENGAGE
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a Telephone Reminiscence Program

NCT05977608
View directory record Official record
Conditions
Mental Health, Loneliness, Social Isolation
Interventions
Telephone Reminiscence Intervention
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional

Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults

NCT04480112
View directory record Official record
Conditions
Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Technology based social interactions, No research related technology based social interactions
Behavioral · Other
Lead sponsor
Boston University
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Results available

Engage Psychotherapy to Promote Connectedness in Caregivers

NCT04176601
View directory record Official record
Conditions
Loneliness, Social Isolation, Caregiver Burnout
Interventions
Engage coaching
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Not listed Not applicable Interventional

Acceptability/Feasibility of COVID-19 Intervention

NCT05019053
View directory record Official record
Conditions
Social Isolation, Emotional Disorder
Interventions
Coping Crew
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Jul 24, 2026, 9:16 AM EDT
Completed No phase listed Observational

Discharge Functional Status and Rehospitalization in the Elderly

NCT02041585
View directory record Official record
Conditions
Social Isolation, Depression, Anxiety, Debility
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

NCT04281654
View directory record Official record
Conditions
Social Isolation, Mental Status Change, Cognitive Impairment, Physical Activity, Quality of Life, Self-Perception
Interventions
Active Social Conversation
Other
Lead sponsor
George Mason University
Other
Eligibility
65 Years to 100 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Manassas, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional Results available

Mindfulness to Reduce Loneliness in Older Caregivers

NCT04560088
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Mindfulness, Breathing
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

NCT06919094
View directory record Official record
Conditions
Apathy, Loneliness, Reminiscence Therapy
Interventions
Life Story Club
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Social Disconnection Study

NCT06705348
View directory record Official record
Conditions
Social Disconnection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional

Tele-BA for Home-Delivered Meals Clients

NCT04131790
View directory record Official record
Conditions
Social Isolation
Interventions
Tele-Behavioral Activation, Tele-Friendly Visiting
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
60 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jul 24, 2026, 9:16 AM EDT
Completed Not applicable Interventional

Alcohol Cessation Among Head and Neck Cancer Survivors

NCT05570851
View directory record Official record
Conditions
Head and Neck Cancer, Alcohol Use, Unspecified
Interventions
Alcohol Cessation Text Messages, Usual Care
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Jul 24, 2026, 9:16 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

NCT07111026
View directory record Official record
Conditions
Occupational Stress, Gender Related Stress, Social Isolation, Hypertension, Pre Diabetes, Diabetes, Obesity
Interventions
Sisters for Heart Health, Basic intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Ellenton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 24, 2026, 9:16 AM EDT