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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:09 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 113 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Isolation, Social Clear all

Conditions: Depression, Loneliness, Social Isolation, Depressive Disorder, Mood Disorders, Mental Disorder
Interventions: Empower@Home:Connected; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 60 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Mental Health Disorder, Social Isolation, Stigma, Social
Interventions: Young Women of Today; Behavioral
Lead sponsor: West Chester University of Pennsylvania; Other
Eligibility: 14 Years to 18 Years · Female only
Enrollment: 183 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: West Chester, Pennsylvania

Conditions: Depression
Interventions: Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits; Behavioral · Other
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Suicidal Thoughts and Behaviors, Social Isolation
Interventions: Qnnections, Enhanced Usual Care; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: San Diego, California

Conditions: Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
Interventions: Technology based social interactions, No research related technology based social interactions; Behavioral · Other
Lead sponsor: Boston University; Other
Eligibility: Not listed
Enrollment: 196 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Social Isolation or Loneliness
Interventions: Talk2gether program; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 65 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Social Isolation in Older Adults, Social Isolation or Loneliness, Social Isolation
Interventions: Social Connection Collective: Open-Label Pilot, Social Connection Collective: Pilot; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 62 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Aging, Hiv, Loneliness, Social Isolation
Interventions: Village Model implementation; Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: San Diego, California

Conditions: Social Isolation, Loneliness, Suicidal Ideation
Interventions: Social Engage (S-ENGAGE), The Healthy Lifestyles Education Program; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Loneliness, Social Isolation
Interventions: Combatting Social Isolation, Health Education Training; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 60 Years and older
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Depression
Interventions: Rejection and Acceptance Feedback; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 13 Years to 17 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Perceived Social Isolation
Interventions: Pregnenolone 175mg, Pregnenolone 400mg, Placebo; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 21 Years to 80 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Apathy, Loneliness, Reminiscence Therapy
Interventions: Life Story Club; Behavioral
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Social Isolation, Loneliness, Suicide Ideation, Quality of Life
Interventions: Social Engage Coaching (S-ENG); Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 60 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Social Exclusion, Prejudice, Racial, Prejudice, Sexism, Peer Group
Interventions: Developing Inclusive Youth (DIY); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 7 Years to 12 Years
Enrollment: 885 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: College Park, Maryland

Conditions: Social Isolation, Fall
Interventions: Exercise, Health Class; Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 50 Years and older
Enrollment: 671 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 9
States / cities: Beverly Hills, California • Los Angeles, California • West Hollywood, California

Conditions: Aging, Social Isolation
Interventions: VSOP training, MLA control; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 60 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 4
States / cities: Fairport, New York • Pittsford, New York • Rochester, New York

Conditions: Parkinson Disease
Interventions: Community walking program using Nordic walking poles; Behavioral
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 30 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Social Isolation
Interventions: CONNECTED, VET BEFRIENDING; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 264 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Occupational Stress, Gender Related Stress, Social Isolation, Hypertension, Pre Diabetes, Diabetes, Obesity
Interventions: Sisters for Heart Health, Basic intervention; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 269 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Ellenton, Georgia

Conditions: Social Disconnection
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 55 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Diabetes, Diabete Type 2, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes Type 1, Diabetes Mellitus
Interventions: Virtual Diabetes Wellness Classes and Medically Tailored Meals; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Social Isolation in Older Adults, Social Isolation or Loneliness, Social Isolation, Quality of Life, Disability Physical, Homebound Persons
Interventions: CAPABLE Care + Connect - Open Label Pilot, CAPABLE Care + Connect - Pilot; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Malnutrition, Loneliness
Interventions: VideoDine; Behavioral
Lead sponsor: Cornell University; Other
Eligibility: 60 Years to 95 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Ithaca, New York

Search by objective public record fields.

Empower@Home:Connected - Feasibility and Preliminary Effect Study

Peer Support Intervention to Mitigate Social Isolation and Stigma of Adolescent Motherhood in Zimbabwe

Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities

Qnnections: Refinement and Pilot Trial of a Suicide Prevention Intervention to Increase Social Connection

Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults

Talk2gether Program for Social Connection in Older Adults

Social Connection Collective for Older Adults in Subsidized Housing

2nd AC+: New Village Model

Culture and Well-Being for Latinos

Combatting Social Isolation in Older Adults

Teen Brain Online II: Understanding How Social Media Affects the Teen Brain

Effects of Pregnenolone on Perceived Social Isolation

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

Study 1: Social Engage Coaching R61 Phase

Developing Inclusive Youth: Promoting Intergroup Friendships and Inclusive Classrooms in Childhood

The Impact of Community Exercise on Social Connectedness and Falls in Older Adults: Leveraging Exercise to Age in Place

HARP-Project 1 Cognitive Training

10,000 Step Club: Community Walking Program for People with Parkinson's Disease

Increasing Veterans' Social Engagement and Connectedness

Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

Social Disconnection Study

Native American Diabetes Project

CAPABLE Care + Connect

Video Chat During Meals to Improve Nutritional Intake in Older Adults