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Showing 1–24 of 111 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Isolation, Social Clear all
Completed No phase listed Observational

Discharge Functional Status and Rehospitalization in the Elderly

NCT02041585
View directory record Official record
Conditions
Social Isolation, Depression, Anxiety, Debility
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight

NCT03786016
View directory record Official record
Conditions
Resilience, Mood, Performance, Stress, Psychological
Interventions
8-Days in an Isolation, Confinement Unit
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Increasing Veterans' Social Engagement and Connectedness

NCT06467214
View directory record Official record
Conditions
Social Isolation
Interventions
CONNECTED, VET BEFRIENDING
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CAPABLE Care + Connect

NCT07123298
View directory record Official record
Conditions
Social Isolation in Older Adults, Social Isolation or Loneliness, Social Isolation, Quality of Life, Disability Physical, Homebound Persons
Interventions
CAPABLE Care + Connect - Open Label Pilot, CAPABLE Care + Connect - Pilot
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Qnnections: Refinement and Pilot Trial of a Suicide Prevention Intervention to Increase Social Connection

NCT06803329
View directory record Official record
Conditions
Suicidal Thoughts and Behaviors, Social Isolation
Interventions
Qnnections, Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Telephone Calls for Health for Homebound Older Adults

NCT04595708
View directory record Official record
Conditions
Loneliness, Social Isolation, Depression
Interventions
Phone Call
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

NCT07111026
View directory record Official record
Conditions
Occupational Stress, Gender Related Stress, Social Isolation, Hypertension, Pre Diabetes, Diabetes, Obesity
Interventions
Sisters for Heart Health, Basic intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Ellenton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intelligent Personal Assistant for Managing Depression in Homebound Older Adults

NCT04900272
View directory record Official record
Conditions
Aging, Physical Dependence
Interventions
VIPA and companion booklet
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Peer Support Intervention to Mitigate Social Isolation and Stigma of Adolescent Motherhood in Zimbabwe

NCT05213182
View directory record Official record
Conditions
Mental Health Disorder, Social Isolation, Stigma, Social
Interventions
Young Women of Today
Behavioral
Lead sponsor
West Chester University of Pennsylvania
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility of Remote Home Support Coaches (SOCIAL Study)

NCT04772820
View directory record Official record
Conditions
Malnutrition, Isolation, Depression, Anxiety, Sedentary Behavior, Loneliness
Interventions
Telephone-based coaching
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
75 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Sep 20, 2026, 9:22 AM EDT
Not yet recruiting Not applicable Interventional

Testing a Peer-Support Group for Veterans Who Hear Voices

NCT07555275
View directory record Official record
Conditions
Psychotic Disorders, Hallucinations, Auditory, Social Isolation
Interventions
Veteran Voices and Visions (VVV), Wellness Recovery Action Planning (WRAP)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
2
States / cities
West Los Angeles, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Engage Coaching (R33 Phase)

NCT07488559
View directory record Official record
Conditions
Social Connection, Loneliness, Suicide Ideation, Social-emotional Quality of Life
Interventions
Social Engage Coaching (S-ENG)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Terminated Not applicable Interventional

Native American Diabetes Project

NCT05088616
View directory record Official record
Conditions
Diabetes, Diabete Type 2, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes Type 1, Diabetes Mellitus
Interventions
Virtual Diabetes Wellness Classes and Medically Tailored Meals
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 21, 2025 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional

Utilizing Novel Information Technology to Promote Exercise and Well-Being in Adolescents and Young Adults With Cancer

NCT03778658
View directory record Official record
Conditions
Adolescent, Young Adult, Cancer, Physical Activity, Psychological Distress, Social Isolation
Interventions
Physical Activity Intervention
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
15 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Sep 20, 2026, 9:22 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

NCT04391816
View directory record Official record
Conditions
Alcohol Drinking, Alcohol-Related Disorders, Pandemic, Psychological Stress
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 100 Years
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 20, 2026, 9:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Creating a Virtual Village for People Aging With HIV During COVID-19

NCT04747756
View directory record Official record
Conditions
Hiv, Depression in Old Age, Isolation, Social, Aging
Interventions
Virtual Village
Other
Lead sponsor
University of California, Riverside
Other
Eligibility
50 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 20, 2026, 9:22 AM EDT
Not listed Not applicable Interventional

Acceptability/Feasibility of COVID-19 Intervention

NCT05019053
View directory record Official record
Conditions
Social Isolation, Emotional Disorder
Interventions
Coping Crew
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors

NCT04913363
View directory record Official record
Conditions
Loneliness, Social Isolation, Mood, Well Aging, Physical Activity, Mobility Limitation
Interventions
Green space
Other
Lead sponsor
University of Virginia
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Protective Effect of Friendship on Peer Rejection in Overweight and Normal Weight Youth

NCT01324661
View directory record Official record
Conditions
Social Exclusion, Control
Interventions
Ostracism
Behavioral
Lead sponsor
University at Buffalo
Other
Eligibility
12 Years to 14 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
View directory record Official record
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Sep 20, 2026, 9:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Yoga for Seniors

NCT04889131
View directory record Official record
Conditions
Aging Well
Interventions
Yoga Program Immediately, Wait-Listed Control, Activity Monitor
Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 16, 2021 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

NCT04915040
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation for Depression
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 20, 2026, 9:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tertulias Social Isolation Women's Groups Study

NCT04254198
View directory record Official record
Conditions
Social Isolation, Depression
Interventions
TERTULIAS structured dialogue peer support groups, Modified Attention Placebo Control (MAPC)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Nov 30, 2025 · Synced Sep 20, 2026, 9:22 AM EDT