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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:49 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 113 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Isolation, Social Clear all

Conditions: Professional Fulfillment, Burnout, Social Isolation or Loneliness
Interventions: Commensality groups; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: Not listed
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Opioid Use Disorder, Loneliness, Social Isolation
Interventions: Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Healthy, Subjective Cognitive Decline (SCD), Sedentary Behavior, Social Isolation in Older Adults
Interventions: Self-monitoring; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 60 Years and older
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Depression
Interventions: Behavioral Activation for Depression; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 65 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Social Rejection, Attachement Style
Interventions: Social Rejection Feedback, Social Acceptance; Behavioral
Lead sponsor: University of North Carolina, Wilmington; Other
Eligibility: 21 Years to 25 Years
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Wilmington, North Carolina

Conditions: Social Connection, Loneliness, Suicide Ideation, Social-emotional Quality of Life
Interventions: Social Engage Coaching (S-ENG); Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 60 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Depression, Anxiety, Loneliness
Interventions: Stay Connected, Treatment as usual; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 60 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Social Isolation, Depression, Anxiety, Debility
Interventions: Not listed
Lead sponsor: Northwestern University; Other
Eligibility: 65 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Coronary Artery Disease, Proteus Syndrome, Coffin - Sins Syndrome, Familial Isolated Hyperparathyroidism, Dubouitz Syndrome
Interventions: Not listed
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Alcohol Drinking, Alcohol-Related Disorders, Pandemic, Psychological Stress
Interventions: Not listed
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 1,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Social Isolation, Loneliness
Interventions: Experimental Health Communication, Simulated Social Media Platform Only; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 29 Years
Enrollment: 1,900 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Stress, Psychological, Social Isolation, Physical Activity
Interventions: Family outings, Park prescription, Pedometry, Case Management; Behavioral · Device
Lead sponsor: UCSF Benioff Children's Hospital Oakland; Other
Eligibility: 4 Years and older
Enrollment: 156 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Oakland, California

Conditions: Social Isolation in Older Adults
Interventions: PRISM 2.0 Condition, Tablet Condition; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 65 Years and older
Enrollment: 248 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 4
States / cities: Miami, Florida • Tallahassee, Florida • Atlanta, Georgia + 1 more

Conditions: Social Isolation, Loneliness
Interventions: Connect for Caregivers; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 50 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 2
States / cities: Rochester, New York

Conditions: Substance Use Disorders
Interventions: CBT for Loneliness, CBT for Substance Use Disorder; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Canandaigua, New York

Conditions: Depression
Interventions: Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits; Behavioral · Other
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Social Isolation, Social Support (Formal and Informal), Well-being/Quality of Life
Interventions: PRISM C: Computer Condition, PRISM B: Notebook Condition; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 65 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Memory Disorders, Mild Cognitive Impairment, Dementia, Social Isolation, Caregiver Burden
Interventions: Social Reminder System; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Military Family, Mental Health Disorder, Social Skills, Social Isolation, Communication, Quality of Life
Interventions: avatar-based training; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mild Cognitive Impairment (MCI), Social Isolation
Interventions: AI-based conversational intervention; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 75 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mental Health, Loneliness, Social Isolation
Interventions: Telephone Reminiscence Intervention; Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 60 Years and older
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Storrs, Connecticut

Conditions: Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders, Mental Disorders
Interventions: Empower@Home; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Exercise, Behavior, Loneliness, Social Isolation
Interventions: Virtual Reality, Video Conference; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 45 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Adherence, Treatment, Social Isolation
Interventions: Adherence Promotion With Person-centered Technology (APPT) System with Social Functions; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 65 Years to 90 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Tallahassee, Florida

Search by objective public record fields.

Commensality Groups: A Professional Fulfillment Intervention for Medical Students in Their Clinical Years

Intervening on Opioid Use and Loneliness

Increasing Physical Activity Through Social Support and Stress Resilience

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

Does Attachment Anxiety Moderate the Influence of Social Rejection on Alcohol Use Among Young Adults?

Engage Coaching (R33 Phase)

Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults

Discharge Functional Status and Rehospitalization in the Elderly

Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

Keep Social Study for Young Adults

Stay Healthy In Nature Everyday: Family Nature Outings in a Low Income Population

PRISM 2.0 in Diverse Living Contexts

Connect for Caregivers

Substance Use and Loneliness

Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)

A Personalized Reminder Information and Social Management System

A Mobile Informatics Solution to Assist Caregivers in Care Coordination and Monitoring Social Engagement

Blue Star Cares: Innovative Approaches to Helping Military-Connected Caregivers

AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults

The Impact of a Telephone Reminiscence Program

A Single Group Study of Empower@Home-an Internet Cognitive Behavioral Therapy Intervention

The VESPA Pilot Study

Social Functions to Promote Home-based Cognitive Training