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Showing 25–39 of 15 matching trials from the live ClinicalTrials.gov search.

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Filters: Condition: Joint Damage Clear all

Conditions: Cartilage Injury, Cartilage Damage
Interventions: Cryopreserved Osteochondral Allograft; Procedure
Lead sponsor: AlloSource; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 3
States / cities: Chicago, Illinois • Lexington, Kentucky • Cincinnati, Ohio

Conditions: Rheumatoid Arthritis
Interventions: Tocilizumab, Placebo to tocilizumab, Methotrexate, Placebo to methotrexate; Drug
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 18 Years and older
Enrollment: 1,162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 61
States / cities: Anniston, Alabama • Huntsville, Alabama • Tuscaloosa, Alabama + 54 more

Conditions: Hurler Syndrome, Cerebral Palsy, Juvenile Rheumatoid Arthritis, Crohn Disease, HIV Infections
Interventions: Growth Hormone, Whole body Protein turnover, DEXA scan; Drug · Procedure
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 3 Years to 17 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Rheumatoid Arthritis
Interventions: MEDI-522, Placebo; Biological · Other
Lead sponsor: MedImmune LLC; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 29
States / cities: Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 24 more

Conditions: Rheumatoid Arthritis
Interventions: Subcutaneous Abatacept; Biological
Lead sponsor: Orrin M Troum, M.D. and Medical Associates; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Cartilage Injury, Cartilage Damage
Interventions: Articular cartilage repair; Other
Lead sponsor: AlloSource; Industry
Eligibility: Not listed
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 5
States / cities: Mobile, Alabama • Wheat Ridge, Colorado • Washington D.C., District of Columbia + 2 more

Conditions: Psoriatic Arthritis
Interventions: Secukinumab; Biological
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 997 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 22
States / cities: Upland, California • Aurora, Colorado • Denver, Colorado + 16 more

Conditions: Spinal Cord Injury, Multiple Sclerosis, Muscular Dystrophy, Cerebral Palsy, Spina Bifida, Amputation, Arthritis, Stroke
Interventions: Educational session to promote physical activity, Minimal contact; Other
Lead sponsor: University of Kansas; Other
Eligibility: 18 Years to 65 Years
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Lawrence, Kansas

Conditions: Hemophilia A With Inhibitors
Interventions: recombinant activated factor VII; Drug
Lead sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico; Other
Eligibility: Up to 8 Years · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 3
States / cities: Los Angeles, California • Atlanta, Georgia • Kansas City, Missouri

Conditions: Apoptotic DNA Damage, Rheumatoid Arthritis, T-cell Lymphocytosis
Interventions: Group 1 or Orencia treated group, Group 2 (DMARDS treated group); Drug · Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alkaptonuria
Interventions: Nitisinone (NTBC); Drug
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 30 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions: Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture; Biological · Other
Lead sponsor: ISTO Technologies, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 9
States / cities: Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more

Conditions: Cerebral Palsy, Arthrogryposis, Spinal Muscular Atrophy, Other Central Nervous System or Musculoskeletal Disorders
Interventions: Power mobility; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 14 Months to 30 Months
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Articular Cartilage Defects in the Knee Joint
Interventions: GelrinC, Microfracture historical control arm; Device · Other
Lead sponsor: Regentis Biomaterials; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 13
States / cities: La Mesa, California • Orange, California • Denver, Colorado + 10 more

Conditions: Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
Interventions: Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: Up to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 4
States / cities: Los Angeles, California • Santa Monica, California • Chicago, Illinois

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Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella

A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis

Effects of Growth Hormone in Chronically Ill Children

Effects of MEDI-522 On Disease Activity and Progression of Joint Damage in Patients With Active Rheumatoid Arthritis Suboptimally Responding to Methotrexate

Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage

ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry

Study to Demonstrate the Efficacy (Including Inhibition of Structural Damage), Safety and Tolerability up to 2 Years of Secukinumab in Active Psoriatic Arthritis

A Randomized Exercise Trial for Wheelchair Users

rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors

Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis

Long-Term Study of Nitisinone to Treat Alkaptonuria

Neocartilage Implant to Treat Cartilage Lesions of the Knee

Effects of Power Mobility on Young Children With Severe Motor Impairments

Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy