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ClinicalTrials.gov public records Last synced Nov 12, 2026, 5:17 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions: Not listed
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 5
States / cities: Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more

Conditions: Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions: Anesthesia Type; Procedure
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 12,466 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: South San Francisco, California

Conditions: Osteoarthritis
Interventions: Patient record review, Radiographs, and questionaires.; Other
Lead sponsor: Medacta USA; Industry
Eligibility: Not listed
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities
Interventions: NexGen LPS-Flex Mobile Bearing Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: Not listed
Enrollment: 266 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2021
U.S. locations: 3
States / cities: Tamarac, Florida • Auburn Hills, Michigan • Knoxville, Tennessee

Conditions: Total Hip Replacement (Non-inflammatory)
Interventions: Novation Ceramic; Device
Lead sponsor: Exactech; Industry
Eligibility: 21 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2021
U.S. locations: 5
States / cities: Fort Lauderdale, Florida • Cumming, Georgia • Worcester, Massachusetts + 2 more

Conditions: Osteoarthritis
Interventions: GUIDED IMAGERY, PLACEBO; Behavioral
Lead sponsor: Kent State University; Other
Eligibility: 18 Years and older
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Akron, Ohio

Conditions: Osteo Arthritis Knee, Total Knee Replacement
Interventions: Total Knee Arthroplasty using LEGION™ Total Knee System; Procedure
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2020
U.S. locations: 5
States / cities: Vero Beach, Florida • Des Moines, Iowa • Louisville, Kentucky + 2 more

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Liposomal bupivacaine, 266mg, Bupivacaine 0.5 % with Epinephrine, Ketorolac 30mg, Morphine 10mg, Bupivacaine 0.25% with Epinephrine; Drug
Lead sponsor: Holy Cross Hospital, Florida; Other
Eligibility: 18 Years to 88 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder, Pain, Loss of Function
Interventions: Not listed
Lead sponsor: Loma Linda University; Other
Eligibility: 40 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: San Bernardino, California

Conditions: Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Interventions: Zimmer Trabecular Metal Total Ankle System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2027
U.S. locations: 5
States / cities: Sacramento, California • Grand Rapids, Michigan • Charlotte, North Carolina + 2 more

Conditions: Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
Interventions: ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Interventions: Educational program to address patients' expectations; Behavioral
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 40 Years and older
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis, Knee
Interventions: Strength testing, Short Physical Performance Battery (SPPB), Six-minute walk (SMW), Numerical pain scale, Self-assessed function, Muscle biopsies, Determination of 1 Repetition Maximum (1-RM), Blood flow restriction exercise, Borg CR10 scale; Device · Behavioral · Procedure
Lead sponsor: University of Florida; Other
Eligibility: 55 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Arthroplasty, Replacement, Knee
Interventions: (Bupivacaine Liposome Injectable Suspension), Standard Preparation; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Orange, California

Conditions: Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle, Talar Dysfunction
Interventions: Total Talus Replacement (TTR); Device
Lead sponsor: Restor3D; Industry
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2031
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Talus, Ankle Arthropathy
Interventions: Total Talus Replacement (TTR), Total Ankle Total Talus Replacement (TATTR), Total Ankle Total Talus Replacement + Subtalar Fusion (TATTR + STJ), Total Talus Replacement + Subtalar Fusion (TTR + STJ); Procedure
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Paducah, Kentucky • Bellevue, Ohio

Conditions: Osteoarthritis
Interventions: Decision Aid Video, Motivational Interviewing, MI plus Decision aid, Attention control; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years and older
Enrollment: 663 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 3
States / cities: Cleveland, Ohio • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Postoperative Pain, Knee Osteoarthritis
Interventions: Total knee replacement, COOLIEF; Procedure · Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 65 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis
Interventions: Evicel fibrin sealant; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 20 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Arthritis
Interventions: X-rays and CT scan; Procedure
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 90 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions: Not listed
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Osteoarthritis
Interventions: Total Knee Replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 842 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 11
States / cities: Orange, California • San Diego, California • Fort Collins, Colorado + 8 more

Conditions: Osteoarthritis of the Knee
Interventions: Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery; Procedure
Lead sponsor: Foundation for Southwest Orthopedic Research; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Non-inflammatory Degenerative Joint Disease
Interventions: ASR™-XL Modular Acetabular Cup System, Pinnacle™ acetabular shell; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 265 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 8
States / cities: Rancho Mirage, California • Cumming, Georgia • Morton Grove, Illinois + 5 more

Search by objective public record fields.

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System

A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis

Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

Post Approval Study: NOVATION Ceramic Articulation Hip System

Guided Imagery Response in Total Knee Replacement

LEGION™ Primary Safety and Efficacy

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery

Zimmer Trabecular Metal Total Ankle PMCF

iPACK Block With Dexamethasone For Total Knee Replacement

Addressing Patients' Expectations of Total Knee Arthroplasty in a Randomized Trial

Blood Flow Restriction Exercise Study

Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj

Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)

Retrospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement

Educational Intervention for Knee Pain

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement

Sleep Patterns After Total Joint Replacement Surgery

10003 PRO Current Products

A Comparative Study of Knee Systems

Multi-Center Comparative Trial of the ASR™-XL Acetabular Cup System vs. the Pinnacle™ Metal- on- Metal Total Hip System