Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 13, 2026, 10:19 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Postoperative Pain, Knee Osteoarthritis
Interventions: Total knee replacement, COOLIEF; Procedure · Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 65 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis, Post Traumatic Degenerative Disease
Interventions: EPIK™ uni-compartmental knee; Device
Lead sponsor: Encore Medical, L.P.; Industry
Eligibility: 18 Years to 60 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Kyle, Texas

Conditions: Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative
Interventions: Bupivacaine Liposome Injection, Standard Therapy; Drug · Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck, Avascular Necrosis of the Femoral Head
Interventions: Z1 Femoral Hip System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 5
States / cities: Platte City, Missouri • Charlotte, North Carolina • Cleveland, Ohio + 2 more

Conditions: Knee Osteoarthritis
Interventions: Zimmer, Stryker; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Degenerative Joint Disease, Osteoarthritis, Hip, Avascular Necrosis of Hip, Traumatic Arthropathy-Hip
Interventions: Hip Innovation Technology Reverse Hip Replacement System, Already-marketed semi-constrained uncemented hip systems using a metal-on-XLPE or ceramic-on-XLPE bearing combination.; Device
Lead sponsor: Hip Innovation Technology; Industry
Eligibility: 50 Years to 75 Years
Enrollment: 288 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2038
U.S. locations: 6
States / cities: Miami, Florida • Tampa, Florida • Baltimore, Maryland + 2 more

Conditions: Osteoarthritis, Hip
Interventions: OMNI Apex Modular™ Hip Device, OMNI Apex ARC™ Hip Device; Device
Lead sponsor: Spokane Joint Replacement Center; Other
Eligibility: 20 Years to 80 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2018
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Osteoarthritis
Interventions: GUIDED IMAGERY, PLACEBO; Behavioral
Lead sponsor: Kent State University; Other
Eligibility: 18 Years and older
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Akron, Ohio

Conditions: Continuous Local Infiltration Analgesia, Intra-articular Catheter, Total Knee Arthroplasty
Interventions: Intra-articular catheter, Routine Standard of Care Treatment; Device · Other
Lead sponsor: OrthoCarolina Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Ankle Osteoarthritis
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 1,043 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Osteoarthritis
Interventions: Metal-on-metal primary total hip arthroplasty (DePuy ); Device
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Alexandria, Virginia

Conditions: Osteoarthritis
Interventions: Total hip arthroplasty; Device
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 2
States / cities: Boston, Massachusetts • Alexandria, Virginia

Conditions: Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
Interventions: Tranexamic Acid (Oral), Tranexamic Acid (Intravenous); Drug
Lead sponsor: The New England Baptist Hospital; Other
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Non-inflammatory Joint Diseases
Interventions: Total hip replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 392 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2011
U.S. locations: 8
States / cities: Little Rock, Arkansas • Orange, California • Palm Bay, Florida + 5 more

Conditions: Prosthetic Joint Infection, Surgical Skin Infection
Interventions: Integuseal; Device
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years to 80 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions: I-beam design, Cruciate design; Device
Lead sponsor: Biomet Orthopedics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Warsaw, Indiana

Conditions: Osteoarthritis, Knee
Interventions: Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis, Post-traumatic; Arthrosis
Interventions: methylprednisolone acetate, active comparator; Drug
Lead sponsor: New Lexington Clinic; Other
Eligibility: 18 Years to 95 Years
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Arthritis
Interventions: X-rays and CT scan; Procedure
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 90 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Arthritis
Interventions: Total hip replacement; Procedure
Lead sponsor: Tennessee Orthopedic Alliance; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Hip Osteoarthritis, Arthroplasty, Replacement, Hip
Interventions: Educational program to address patients' expectations; Behavioral
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 55 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2003
U.S. locations: 1
States / cities: New York, New York

Conditions: Total Knee Arthroplasty
Interventions: NEUROCUPLE™ Patch, Placebo Patch; Device
Lead sponsor: nCap Medical; Industry
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Osteoarthritis
Interventions: Total knee arthroplasty; Procedure
Lead sponsor: Exactech; Industry
Eligibility: Not listed
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee, Rheumatoid Arthritis, Deformity of Knee
Interventions: Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System, Physica Cruciate Retaining Knee System with LMC Liner; Device
Lead sponsor: Limacorporate S.p.a; Industry
Eligibility: 22 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2030
U.S. locations: 5
States / cities: Rancho Mirage, California • Daytona Beach, Florida • Aurora, Illinois + 2 more

Search by objective public record fields.

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

Post-Market Study of the EPIK Knee System

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

Z1 Hip System: Post-Market Clinical Follow Up Study

Total Knee Arthroplasty: Functional and Clinical Outcomes

Safety and Effectiveness of the HIT Reverse HRS

Femoral Remodeling Following Total Hip Arthroplasty With OMNI Apex Modular™ and OMNI Apex ARC™ Stem Compared to Competitive Designs

Guided Imagery Response in Total Knee Replacement

Intra-Articular Catheter Total Knee Arthroplasty

Total Ankle Replacement for Ankle Arthritis

A Five-Year Metal-on-Metal Retrospective Clinical Study

Analysis of Crosslinked and Conventional Polyethylene Explants

Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery

Metal on Metal Versus Ceramic on Metal Hip Replacement

Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement

I-beam and Cruciate Tibial Components Used in Total Knee Replacement

Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty

Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement

Restoration of Leg Length, Offset, and Center of Rotation in Total Hip Replacement

Addressing Patients' Expectations of Total Hip Arthroplasty in a Randomized Trial

NEUROCUPLE™ in TKA Patients to Enhance Pain Management

Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)

Physica System Total Knee Replacement Registry Study