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ClinicalTrials.gov public records Last synced Nov 14, 2026, 12:07 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 289–312 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Pain, Postoperative
Interventions: Caffeine, Placebo oral tablet; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Egg Harbor, New Jersey

Conditions: Non-inflammatory Degenerative Joint Disease
Interventions: 36 mm ceramic head on a ceramic acetabular liner, 28 mm ceramic head on a polyethylene acetabular liner; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2013
U.S. locations: 5
States / cities: Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more

Conditions: Lumbar Spine Degeneration
Interventions: MOTUS Total Joint Replacement; Device
Lead sponsor: 3Spine; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 14
States / cities: Los Angeles, California • Steamboat Springs, Colorado • Deerfield Beach, Florida + 11 more

Conditions: Hip Osteoarthritis
Interventions: Lumbar plexus block, Quadratus lumborum type 3 block, Ropivacaine injection; Procedure · Drug
Lead sponsor: Sharad Khetarpal; Other
Eligibility: 18 Years to 90 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Total Joint Replacement Surgery, Preoperative Anxiety
Interventions: Guided imagery and positive affirmations; Behavioral
Lead sponsor: Hackensack Meridian Health; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Old Bridge, New Jersey

Conditions: Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis
Interventions: PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 181 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 5
States / cities: Vail, Colorado • Westminster, Colorado • Springfield, Illinois + 2 more

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 21 Years and older
Enrollment: 1,950 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2022
U.S. locations: 5
States / cities: Glenview, Illinois • Woodbury, Minnesota • Syracuse, New York + 2 more

Conditions: Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated, Tibial Component Revision
Interventions: Constrained Condylar bearing, posterior stabilized bearing; Device
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2038
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis
Interventions: Trilogy AB Acetabular Hip Implant System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Fort Lauderdale, Florida • Philadelphia, Pennsylvania

Conditions: Systemic Lupus Erythematosus
Interventions: estradiol, ethinyl estradiol, medroxyprogesterone, norethindrone; Drug
Lead sponsor: National Center for Research Resources (NCRR); NIH
Eligibility: 0 Years and older · Female only
Enrollment: 970 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2000
U.S. locations: 17
States / cities: Birmingham, Alabama • Los Angeles, California • San Francisco, California + 12 more

Conditions: Osteo Arthritis Knee
Interventions: iTotal Posterior Stabilized (PS) Knee Replacement System; Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 2
States / cities: Nashville, Tennessee • Huntington, West Virginia

Conditions: Osteoarthritis
Interventions: AGG-523 (Aggrecanase Inhibitor); Drug
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer; Industry
Eligibility: 55 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 5
States / cities: Boston, Massachusetts • Newton, Massachusetts • Winchester, Massachusetts + 1 more

Conditions: Arthritis, Rheumatoid
Interventions: INFINITY™ with ADAPTIS™ Technology Total Ankle System; Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 22 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2035
U.S. locations: 13
States / cities: Gilbert, Arizona • Rancho Mirage, California • Aurora, Colorado + 10 more

Conditions: Osteoarthritis
Interventions: PRT + FM, Usual Care; Behavioral · Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 40 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis, Osteoarthritis, Knee
Interventions: Clinic-based outpatient exercise group, Community-based exercise group; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 60 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Knee Replacement, Total
Interventions: TKA Journey - patient education, Optimized Rehab Scheduling, Usual Rehab, Physical Therapist reminders; Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions: Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone; Drug
Lead sponsor: Miller Orthopedic Specialists; Other
Eligibility: 18 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Council Bluffs, Iowa

Conditions: Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis, Prior Ankle Fusion
Interventions: Salto Talaris Ankle; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2023
U.S. locations: 2
States / cities: San Antonio, Texas • Milwaukee, Wisconsin

Conditions: Osteoarthritis
Interventions: Rehabilitation after joint replacement surgery; Behavioral
Lead sponsor: MedStar National Rehabilitation Network; Other
Eligibility: 21 Years and older
Enrollment: 2,384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
Interventions: Astaxanthin, Placebo; Drug · Other
Lead sponsor: Prisma Health-Midlands; Other
Eligibility: 18 Years to 99 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
Interventions: ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Interventions: Journey II posterior cruciate retaining total knee arthroplasty, Journey II posterior bi-cruciate retaining total knee arthroplasty; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 40 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 4
States / cities: Chattanooga, Tennessee • Knoxville, Tennessee

Conditions: Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions: Continuum Metal on Polyethylene Acetabular System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 195 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2026
U.S. locations: 2
States / cities: Fremont, California • Denver, Colorado

Conditions: Knee Osteoarthritis
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 50 Years and older
Enrollment: 852 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Caffeine Study for Pain Control Following Total Joint Replacement

36 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement

MOTUS Total Joint Replacement Investigational Device Exemption Study

Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement

Positive Affirmations and Preoperative Anxiety

ROSA Robot Used in Total Knee Replacement Post Market Study

Massachusetts General Hospital Evaluation of DePuy ASR Hip System

The Use of CCK vs PS in Revision TKAs

Trilogy AB Acetabular Hip System Post Approval Study

Randomized Study of Oral Contraceptives or Hormone Replacement Therapy in Women With Systemic Lupus Erythematosus

A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System

Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement

INFINITY™ With ADAPTIS™ Technology Study

Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement

Comparison of Treatments Following Total Knee Replacement

Knee Replacement Rehabilitation Care Pathways

Liposomal Bupivacaine in Total Knee Arthroplasty

Ankle Joint Replacement Outcomes Study

JOINTS Study - Joint Replacement Outcome in Inpatient Rehabilitation Facilities and Nursing Treatment Sites

Astaxanthin for Management of Inflammation in Knee Osteoarthritis

iPACK Block With Dexamethasone For Total Knee Replacement

Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

Chronic Knee Pain Study