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ClinicalTrials.gov public records Last synced Nov 14, 2026, 12:23 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint, Failed Osteotomies, Failed Unicompartmental Replacement
Interventions: JOURNEY II XR Total Knee System; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2029
U.S. locations: 14
States / cities: Loma Linda, California • Fort Lauderdale, Florida • Aurora, Illinois + 9 more

Conditions: Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Interventions: Consensus TracPatch; Device
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Arthroplasty, Replacement, Hip, Arthritis
Interventions: Not listed
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Osteoarthritis, Post-traumatic Arthritis
Interventions: Vanguard M fixed-bearing or Oxford mobile-bearing prostheses, Total Knee Replacement; Device
Lead sponsor: New Lexington Clinic; Other
Eligibility: 18 Years and older
Enrollment: 324 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Osteoarthritis, Knee
Interventions: iTotal PS Knee Replacement System, Off-the-Shelf Knee Replacement System; Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
Interventions: Primary Total Hip Arthroplasty, Revision Total Hip Arthroplasty; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 177 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2035
U.S. locations: 6
States / cities: Lexington, Kentucky • Omaha, Nebraska • New York, New York + 2 more

Conditions: Arthroplasties, Replacement, Weight Loss, Nutrition
Interventions: Remote dietitian supervised weight loss intervention and mobile app; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 3
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left, Osteoarthritis Knee Right, Knee Pain Chronic, Knee Disease, Arthropathy of Knee Joint
Interventions: MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing); Device
Lead sponsor: LifeBridge Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions: Anesthesia Type; Procedure
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 12,466 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: South San Francisco, California

Conditions: Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions: Total Knee Arthroplasty; Procedure
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 299 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2033
U.S. locations: 12
States / cities: Atlanta, Georgia • Boston, Massachusetts • Novi, Michigan + 8 more

Conditions: Shoulder Pain, Shoulder Arthritis, Shoulder Arthroplasty
Interventions: Perfusion with Indocyanine green; Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Osteoarthritis, Knee, Knee Replacement
Interventions: Mindfulness-based Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 45 Years to 100 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Post-op Pain
Interventions: Oral acetaminophen, IV acetaminophen; Drug
Lead sponsor: Kettering Health Network; Other
Eligibility: 18 Years and older
Enrollment: 515 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Kettering, Ohio

Conditions: Osteoarthritis (OA) of the Hip
Interventions: Reparel Bioactive Sleeve, TED Stocking; Device
Lead sponsor: Reparel; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Fremont, California

Conditions: Obesity, Arthritis
Interventions: propofol, Desflurane; Drug
Lead sponsor: Pedro Paulo Tanaka; Other
Eligibility: 65 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Stanford, California

Conditions: Osteoarthritis
Interventions: Arthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy; Procedure · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 45 Years and older
Enrollment: 351 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2025
U.S. locations: 7
States / cities: Chicago, Illinois • Boston, Massachusetts • Rochester, Minnesota + 4 more

Conditions: Arthroplasty, Replacement, Hip
Interventions: Restoration ADM X3 Device; Device
Lead sponsor: Stryker Orthopaedics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2023
U.S. locations: 9
States / cities: Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 6 more

Conditions: Osteoarthritis, Hip
Interventions: Periarticular injection (Deep injection), Periarticular injection (Superficial injection), Bupivacaine, Placebo; Procedure · Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 50 Years to 75 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Hemophilia A, Factor VIII (FVIII)
Interventions: Half-life factor VIII based replacement therapy, Non-FVIII based replacement therapy; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 6 Months and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2033
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Obesity, Knee Osteoarthritis
Interventions: InBody Band 2; Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 99 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Liposomal bupivacaine, 266mg, Bupivacaine 0.5 % with Epinephrine, Ketorolac 30mg, Morphine 10mg, Bupivacaine 0.25% with Epinephrine; Drug
Lead sponsor: Holy Cross Hospital, Florida; Other
Eligibility: 18 Years to 88 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
Interventions: Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC); Behavioral · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Total Knee Replacement, Total Hip Replacement
Interventions: IV meloxicam, Ketorolac; Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 223 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Osteoarthritis, Knee
Interventions: Liposomal bupivacaine, Standard of Care; Drug
Lead sponsor: OhioHealth; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

JOURNEY II XR Safety and Effectiveness PMCF

TracPatch in Total Knee Arthroplasty

Total Hip Arthroplasty Outcomes With Regional and Multimodal Analgesia

Postoperative Function Following Partial and Total Knee Replacement

A Single Time-Point Study to Evaluate the ConforMIS iTotal (PS) Knee Replacement System Versus Off-the-Shelf

Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA

Weight Loss Before Total Joint Arthroplasty Using A Remote Dietitian and Mobile App

Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty

Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

Subscapularis Indocyanine Green Perfusion Pilot Study

Prediction of Outcomes Following Total Knee Replacement- Pilot

PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement

TED Stocking vs. Reparel Garment After Hip Replacement

Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis

Restoration® Anatomic Dual Mobility (ADM) X3® Acetabular System Study

Minimal Opioid Use After Total Hip Replacement (THR)

TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies

Wearable Bioimpedance Analyzer for Tracking Body Composition Changes

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery

Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)

Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery