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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:11 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–354 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Edematous, Synovitis, Foreign Body Reaction, Osteolysis
Interventions: Placebo, Apatone®B; Drug
Lead sponsor: IC-MedTech Corporation; Industry
Eligibility: 50 Years to 85 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Akron, Ohio

Conditions: Osteoarthritis of the Knee
Interventions: Standard cutting guide for TKA, Otismed MRI generated cutting guide for TKA; Device
Lead sponsor: Phoenix VA Health Care System; Federal
Eligibility: 40 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2014
U.S. locations: 2
States / cities: Phoenix, Arizona • Salt Lake City, Utah

Conditions: Ankle Arthroplasty, Prosthesis User, Joint Disease
Interventions: Total Ankle Replacement Prosthesis; Device
Lead sponsor: Georgia Institute of Technology; Other
Eligibility: 18 Years to 79 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation, Knee Osteoarthritis, Knee Disease, Knee Injuries, Opioid Use, Opioid Dependence, Opioid Use Disorder
Interventions: Mindful meditation; Behavioral
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 89 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis, Knee
Interventions: Conformis iTotal Identity Knee Replacement System; Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Boynton Beach, Florida • Nashville, Tennessee

Conditions: Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
Interventions: Not listed
Lead sponsor: Biomet Orthopedics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 4
States / cities: Chicago, Illinois • Pittsburgh, Pennsylvania • Fredericksburg, Virginia + 1 more

Conditions: Pain, Osteoarthritis
Interventions: Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block; Procedure
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 80 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Osteoarthritis, Total Knee Arthroplasty
Interventions: Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages; Device · Other
Lead sponsor: CoolSystems, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 10
States / cities: San Diego, California • Honolulu, Hawaii • Winfield, Illinois + 7 more

Conditions: Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis, Humeral Fractures
Interventions: Not listed
Lead sponsor: Biomet Orthopedics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2016
U.S. locations: 4
States / cities: Tampa, Florida • Indianapolis, Indiana • Boston, Massachusetts + 1 more

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Atlantis, Florida

Conditions: Rheumatoid Arthritis
Interventions: Not listed
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 90 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Metallosis, Pain, Total Hip Replacement, Total Knee Replacement
Interventions: Questionnaires, Interviews, Blood draw, Magnetic Resonance Imaging, Echocardiogram; Behavioral · Other · Radiation + 1 more
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 100 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Interventions: Zimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty, Zimmer-Biomet Posterior Stabilizing total knee arthroplasty; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Bryn Mawr, Pennsylvania • Knoxville, Tennessee

Conditions: Total Knee Replacement, Postoperative Pain
Interventions: Bupivacaine HCl, F14 (celecoxib); Drug
Lead sponsor: Arthritis Innovation Corporation; Industry
Eligibility: 45 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Denver, Colorado • Dayton, Ohio • San Antonio, Texas

Conditions: Osteoarthritis, Knee
Interventions: Intracapsular Injection, Periarticular Injection; Procedure
Lead sponsor: Broward Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions: Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.; Procedure
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities
Interventions: NexGen LPS-Flex Mobile Bearing Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: Not listed
Enrollment: 266 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2021
U.S. locations: 3
States / cities: Tamarac, Florida • Auburn Hills, Michigan • Knoxville, Tennessee

Conditions: Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Arthritis
Interventions: Total knee arthroplasty; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 3
States / cities: Denver, Colorado • Pittsburgh, Pennsylvania • Virginia Beach, Virginia

Search by objective public record fields.

Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements

Total Knee Replacement Study Using Standard Cutting Guide vs Otismed MRI Generated Cutting Guide

3D X-ray Motion Analysis of Ankle-foot Motion After Total Ankle Arthroplasty

Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement

A Study to Evaluate the Conformis iTotal Identity Knee Replacement System

A Clinical Investigation of the Balance® Microplasty™ Hip System

Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty

Use of Cold and Compression Therapy With Total Knee Replacement Patients

A Clinical Investigation of the Discovery™ Elbow System

Study Comparing Fit of the iTotal Versus Standard Total Knee Implants

Perioperative Flare in RA: Characterization of Clinical and Biological Features

Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty

Safety and Activity of F14 for Management of Pain Following Total Knee Replacement

Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System