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ClinicalTrials.gov public records Last synced Nov 13, 2026, 9:55 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Arthritis
Interventions: Exparel, Saline; Drug · Other
Lead sponsor: Maimonides Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Arthropathy of Knee Joint
Interventions: Vancomycin; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Osteoarthritis
Interventions: Lactated Ringer, Placebo; Drug
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS), Kienbock's Disease of Adults, Radial Malunion, Ulnar Translocation, Post Traumatic Arthritis, Inflammatory Arthritis, Osteoarthritis, Scaphoid Non-union Advanced Collapse (SNAC)
Interventions: KinematX total wrist arthroplasty system; Device
Lead sponsor: Extremity Medical; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2035
U.S. locations: 4
States / cities: Loma Linda, California • Tampa, Florida • Indianapolis, Indiana + 1 more

Conditions: Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle, Talar Dysfunction
Interventions: Total Talus Replacement (TTR); Device
Lead sponsor: Restor3D; Industry
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2031
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions: Not listed
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Postoperative Pain, Knee Replacement Arthroplasty
Interventions: Nerve Block, Periarticular Injection; Drug
Lead sponsor: Mark J. Spangehl, M.D.; Other
Eligibility: 18 Years to 79 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Knee Arthroplasty
Interventions: Baseline Questionnaire, Operative Data, Intra-operative data will be collected post-operatively, In-hospital post-operative data will be collected, Satisfaction data will be extracted from Press/Ganey and on follow-up questionnaires, Cost Data, Follow-up questionnaires; Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Knee Replacement, Hip Replacement
Interventions: Not listed
Lead sponsor: DC2 Healthcare; Industry
Eligibility: 18 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2012
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Osteoarthritis, Knee
Interventions: TruMatch™ Personalized Solutions, Total Knee Arthroplasty with Conventional Instrumentation.; Other · Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 4
States / cities: Baltimore, Maryland • Saint Paul, Minnesota • Charlotte, North Carolina + 1 more

Conditions: Osteoarthritis, Postoperative Pain
Interventions: Whole blood for genotyping; Genetic
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Arthropathy of Knee, Arthritis Knee, Arthritis, Degenerative
Interventions: Fitbit; Other
Lead sponsor: Benaroya Research Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Osteoarthritis
Interventions: Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional; Procedure
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 50 Years to 85 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 3
States / cities: Boulder, Colorado • Denver, Colorado

Conditions: Osteoarthritis
Interventions: Total Knee Replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 842 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 11
States / cities: Orange, California • San Diego, California • Fort Collins, Colorado + 8 more

Conditions: Osteoarthritis, Knee, Knee Osteoarthritis
Interventions: ConforMIS iUni, iDuo, or iTotal (CR); Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 950 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boynton Beach, Florida

Conditions: Osteoarthritis, Knee
Interventions: Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.; Behavioral
Lead sponsor: Kinex Medical Company, LLC; Industry
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Des Moines, Iowa

Conditions: Shoulder Arthroplasty
Interventions: Liposomal bupivacaine, Bupivacaine with adjuvants; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions: Genetic Panel for Analgesics; Genetic
Lead sponsor: TriHealth Inc.; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions: COC 36mm; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 21 Years to 75 Years
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2023
U.S. locations: 9
States / cities: Sacramento, California • Denver, Colorado • Tampa, Florida + 5 more

Conditions: Osteoarthritis, Knee
Interventions: Custom Patient Instrumentation, Conventional Instruments; Other
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 3
States / cities: Mooresville, Indiana • Bartlesville, Oklahoma • Reston, Virginia

Conditions: Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis
Interventions: Subchondroplasty with Arthroscopy, Arthroscopy Alone; Procedure
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 30 Years to 75 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 12
States / cities: Encinitas, California • Loma Linda, California • Stanford, California + 9 more

Conditions: Prosthetic-joint Infection, Knee Infection, Arthroplasty Complications, Joint Infection, Arthroplasty, Replacement, Knee
Interventions: All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Arthritis, Rheumatoid
Interventions: Silicone metacarpophalangeal joint arthroplasty, Usual care; Procedure · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 80 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2017
U.S. locations: 2
States / cities: Baltimore, Maryland • Ann Arbor, Michigan

Conditions: Osteoarthritis
Interventions: Neuromuscular Electrical Stimulation (NMES), Standard Rehabilitation Protocol; Device · Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 50 Years to 85 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Aurora, Colorado

Search by objective public record fields.

Evaluation Exparel Delivered in Knee Replacement

Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

The KinematX Midcarpal Total Wrist Arthroplasty Registry

Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)

Sleep Patterns After Total Joint Replacement Surgery

Management of Postoperative Pain After Total Knee Replacement.

Hospital for Special Surgery Knee Arthroplasty Cohort

C3 Total Joint Patient Registry

Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation

Acute Pain Genomic Study

Validation of Consumer Activity Monitors in Postoperative Total Arthroplasty Patients

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

10003 PRO Current Products

A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS

Study of the KinexConnect Telerehabilitation System (KCTRS)

Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants

Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study

Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS)

Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty

Subchondroplasty® Knee RCT

Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection

Study of People With Rheumatoid Arthritis Who Require Joint Surgery in the Hand

Early Neuromuscular Electrical Stimulation For Quadriceps Muscle Activation Deficits Following Total Knee Replacement