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ClinicalTrials.gov public records Last synced Nov 13, 2026, 1:50 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Non-inflammatory Degenerative Joint Disease
Interventions: Total Hip Replacement; Procedure
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: 40 Years to 80 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2013
U.S. locations: 1
States / cities: Alexandria, Virginia

Conditions: Arthroplasty, Hemiarthroplasty, Shoulder Pain
Interventions: ReUnion Total Shoulder Arthroplasty (TSA), ReUnion Reverse Shoulder Arthroplasty (RSA); Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 3
States / cities: Peoria, Illinois • Greenville, South Carolina • Nashville, Tennessee

Conditions: Degenerative Joint Disease
Interventions: L2 paravertebral block, periarticular injection group; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Osteoarthritis, Knee
Interventions: Not listed
Lead sponsor: Athens Orthopedic Clinic, P.A.; Other
Eligibility: 18 Years and older
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Postoperative Pain, Delirium, Confusion, Sleep
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery, Total Hip Replacements, Total Hip Replacement Arthroplasty, Suzetrigine, Pain Management, Pain, Nav 1.8, JOURNAVX, Opioid Cessation, Opioid Consumption, Postoperative, Multimodal Analgesia, Randomized Controlled Trial, Randomized Controlled Study, Randomized Controlled Trials
Interventions: Suzetrigine, Placebo; Drug · Other
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Non-inflammatory Joint Disease, Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Post-traumatic Arthritis
Interventions: Total hip replacement/arthroplasty; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2014
U.S. locations: 6
States / cities: Atlanta, Georgia • Springfield, Illinois • Cleveland, Ohio + 2 more

Conditions: Osteoarthritis, Pain
Interventions: Placebo, Fulranumab 1 mg, Fulranumab 3 mg, Opioid; Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 36
States / cities: Birmingham, Alabama • Huntsville, Alabama • Cerritos, California + 33 more

Conditions: Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
Interventions: Not listed
Lead sponsor: Zimmer Biomet; Industry
Eligibility: Not listed
Enrollment: 149 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2016
U.S. locations: 5
States / cities: Rockville, Maryland • Lima, Ohio • West Chester, Ohio + 2 more

Conditions: Degenerative Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Interventions: 3DKnee™ System; Device
Lead sponsor: Encore Medical, L.P.; Industry
Eligibility: 18 Years and older
Enrollment: 229 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2018
U.S. locations: 8
States / cities: Scottsdale, Arizona • Fresno, California • Baltimore, Maryland + 5 more

Conditions: Osteoarthritis
Interventions: Topical Tranexamic Acid, Intravenous Tranexamic Acid; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 100 Years
Enrollment: 640 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Rochester, Minnesota • New York, New York

Conditions: Knee Osteoarthritis
Interventions: DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System, Control; Device
Lead sponsor: More Foundation; Other
Eligibility: 50 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2029
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Interventions: Educational program to address patients' expectations; Behavioral
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 40 Years and older
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: New York, New York

Conditions: Arthroplasty, Replacement, Knee
Interventions: Depodur, sciatic nerve block; Drug · Procedure
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years to 70 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition, Energy Malnutrition Protein
Interventions: Total Knee Arthroplasty, Total Joint Arthroplasty; Procedure
Lead sponsor: University of Connecticut; Other
Eligibility: 50 Years to 70 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Talus, Ankle Arthropathy
Interventions: Total Talus Replacement (TTR), Total Ankle Total Talus Replacement (TATTR), Total Ankle Total Talus Replacement + Subtalar Fusion (TATTR + STJ), Total Talus Replacement + Subtalar Fusion (TTR + STJ); Procedure
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Paducah, Kentucky • Bellevue, Ohio

Conditions: Osteoarthritis
Interventions: Tranexamic Acid (TXA), ε-Aminocaproic Acid (EACA); Drug
Lead sponsor: Miller Orthopedic Specialists; Other
Eligibility: 18 Years to 90 Years
Enrollment: 194 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Council Bluffs, Iowa

Conditions: Arthroplasty, Replacement, Knee
Interventions: (Bupivacaine Liposome Injectable Suspension), Standard Preparation; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Orange, California

Conditions: Hip Arthroplasty
Interventions: Not listed
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Pain, Arthrofibrosis, Osteoarthritis, Knee
Interventions: Hydrocortisone, Dextrose 5% in water (D5W); Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 83 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle, Valgus Deformity, Varus Deformity, Flexion Deformity of Knee
Interventions: Total knee arthroplasty; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2037
U.S. locations: 5
States / cities: Denver, Colorado • Louisville, Kentucky • Baltimore, Maryland + 1 more

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions: Not listed
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 5
States / cities: Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more

Conditions: Knee Osteoarthritis, Knee Rheumatism
Interventions: Obturator nerve regional block, Adductor canal regional block, Saline; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Hip Fracture, Osteoarthritis, Femur Head Necrosis
Interventions: Essential amino acid supplement, Ketoconazole, Placebo; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 30 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Little Rock, Arkansas

Search by objective public record fields.

Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant

A Post-Market Clinical Evaluation of the ReUnion Reversible Fracture (RFX) System

Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty

Study of Patient Outcomes 5 Years After Partial Knee Replacement

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

Suzetrigine in Total Hip Arthroplasty

Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System

Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001

A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement

Post-Market Study of the 3DKnee™ System

Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical

Gait Analysis of a Lateral-Pivot Design Total Knee Replacement

Addressing Patients' Expectations of Total Knee Arthroplasty in a Randomized Trial

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement

Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes

Retrospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement

Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement

Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj

Hospital for Special Surgery Hip Arthroplasty Cohort

Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)

Persona SoluTion PPS Femur PMCF

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?

Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery