- Conditions
- Dry Eye Syndrome, Keratoconjunctivitis Sicca
- Interventions
- Oculeve Intranasal Neurostimulator
- Device
- Lead sponsor
- Oculeve, Inc.
- Industry
- Eligibility
- 22 Years and older
- Enrollment
- 55 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016
- U.S. locations
- 2
- States / cities
- Artesia, California • Newport Beach, California
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Showing 1–24
of 89
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Keratoconjunctivitis Sicca, Sjogren's Syndrome, Lupus Erythematosus, Systemic, Arthritis, Rheumatoid, Scleroderma, Systemic
- Interventions
- Ophthalmic Emulsion
- Drug
- Lead sponsor
- Allergan
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 290 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2001 – 2003
- U.S. locations
- 17
- States / cities
- La Jolla, California • Los Angeles, California • Waterbury, Connecticut + 14 more
- Conditions
- Dry Eye Syndrome, Keratoconjunctivitis Sicca
- Interventions
- Oculeve Intranasal, Sham, Oculeve Extranasal
- Device
- Lead sponsor
- Oculeve, Inc.
- Industry
- Eligibility
- 22 Years and older
- Enrollment
- 48 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016
- U.S. locations
- 2
- States / cities
- Waterbury, Connecticut • Norfolk, Virginia
- Conditions
- Keratoconjunctivitis Sicca
- Interventions
- glycerin, polyethylene glycol 400/propylene glycol
- Drug
- Lead sponsor
- Calm Water Therapeutics LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 16 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2008
- U.S. locations
- 1
- States / cities
- Rochester, New York
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye Syndrome
- Interventions
- Dexamethasone, Artificial tear
- Drug
- Lead sponsor
- Baylor College of Medicine
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2013 – 2015
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Kerato Conjunctivitis Sicca
- Interventions
- KPI-121 Ophthalmic Suspension, Vehicle
- Drug
- Lead sponsor
- Kala Pharmaceuticals, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 901 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 81
- States / cities
- Birmingham, Alabama • Dothan, Alabama • Chandler, Arizona + 64 more
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye
- Interventions
- rebamipide 2% ophthalmic suspension, placebo eye drops
- Drug
- Lead sponsor
- Kubota Vision Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 116 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2011
- U.S. locations
- 19
- States / cities
- Mesa, Arizona • Phoenix, Arizona • Los Angeles, California + 14 more
- Conditions
- Dry Eye Disease, Keratoconjunctivitis Sicca
- Interventions
- Lotemax, Restasis
- Drug
- Lead sponsor
- Ophthalmic Consultants of Long Island
- Other
- Eligibility
- 30 Years to 80 Years
- Enrollment
- 5 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2006 – 2007
- U.S. locations
- 1
- States / cities
- Lynbrook, New York
- Conditions
- Dry Eye Disease
- Interventions
- 1st visit Optive, then 2nd visit Systane, 1st visit Systane, then 2nd visit Optive
- Drug
- Lead sponsor
- University of Texas Southwestern Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2009
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Dry Eye
- Interventions
- RU-101
- Biological
- Lead sponsor
- R-Tech Ueno, Ltd.
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 104 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2014
- U.S. locations
- 1
- States / cities
- Norfolk, Virginia
- Conditions
- Sjögren's Syndrome
- Interventions
- Not listed
- Lead sponsor
- University of California, Los Angeles
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 420 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2018
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Dry Eye Syndromes, Keratoconjunctivitis Sicca, Lacrimal Apparatus Diseases, Keratoconjunctivitis, Eye Diseases, Keratitis, Corneal Disease, Ophthalmic Solution
- Interventions
- Systane Complete, Systane Ultra
- Other
- Lead sponsor
- Ohio State University
- Other
- Eligibility
- 30 Years and older
- Enrollment
- 24 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2019
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye
- Interventions
- Tavilermide ophthalmic solution, Placebo
- Drug · Other
- Lead sponsor
- Mimetogen Pharmaceuticals USA, Inc.
- Industry
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 623 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2020
- U.S. locations
- 22
- States / cities
- Phoenix, Arizona • Los Angeles, California • Newport Beach, California + 19 more
- Conditions
- Dry Eye Syndromes, Keratoconjunctivitis Sicca
- Interventions
- Intranasal Lacrimal Neurostimulator (Oculeve)
- Device
- Lead sponsor
- Oculeve, Inc.
- Industry
- Eligibility
- 22 Years and older
- Enrollment
- 97 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2016
- U.S. locations
- 3
- States / cities
- Phoenix, Arizona • Andover, Massachusetts • Memphis, Tennessee
- Conditions
- Keratoconjunctivitis Sicca
- Interventions
- Low Dose 0.155µg/mL SkQ1 ophthalmic solution, High Dose 1.55µg/mL SkQ1 ophthalmic solution, Placebo (Vehicle) opthalmic solution
- Drug
- Lead sponsor
- Mitotech, SA
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 91 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014
- U.S. locations
- 1
- States / cities
- Andover, Massachusetts
- Conditions
- Keratoconjunctivitis Sicca, Xeropthalmia
- Interventions
- Acupuncture, Sham acupuncture
- Procedure
- Lead sponsor
- Walter Reed Army Medical Center
- Federal
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2011
- U.S. locations
- 1
- States / cities
- Washington D.C., District of Columbia
- Conditions
- Contact Lens, Contact Lens Discomfort, Contact Lens Dryness
- Interventions
- Lifitegrast
- Drug
- Lead sponsor
- EV Clinical Trials
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 21 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- Richardson, Texas
- Conditions
- Dry Eye Disease
- Interventions
- 0.003% AR-15512 ophthalmic solution, Artificial Tears
- Drug · Other
- Lead sponsor
- Alcon Research
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 80 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 4
- States / cities
- Louisville, Kentucky • Garner, North Carolina • Leland, North Carolina + 1 more
- Conditions
- Dry Eye Syndromes, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Interventions
- 5% Tavilermide ophthalmic solution, Vehicle ophthalmic solution
- Drug · Other
- Lead sponsor
- Mimetogen Pharmaceuticals USA, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 642 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 29
- States / cities
- Phoenix, Arizona • Glendale, California • Murrieta, California + 25 more
- Conditions
- Dry Eye
- Interventions
- RPS InflammaDry Detector™
- Device
- Lead sponsor
- Rapid Pathogen Screening
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 206 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2010 – 2011
- U.S. locations
- 8
- States / cities
- Bradenton, Florida • Miami, Florida • Springfield, Missouri + 4 more
- Conditions
- Dry Eye Disease
- Interventions
- Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution
- Drug
- Lead sponsor
- Sylentis, S.A.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 301 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2023
- U.S. locations
- 25
- States / cities
- Chandler, Arizona • Phoenix, Arizona • Glendale, California + 21 more
- Conditions
- Dry Eye
- Interventions
- Dexamethasone phosphate ophthalmic solution, Sodium citrate buffer solution
- Drug
- Lead sponsor
- Eyegate Pharmaceuticals, Inc.
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 198 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2011
- U.S. locations
- 5
- States / cities
- Waterbury, Connecticut • Lewiston, Maine • Andover, Massachusetts + 2 more
- Conditions
- Keratoconjunctivitis Sicca
- Interventions
- Retaine™
- Drug
- Lead sponsor
- Ocusoft, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 42 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014
- U.S. locations
- 1
- States / cities
- Andover, Massachusetts
- Conditions
- Dry Eye Syndrome
- Interventions
- RX-10045, Placebo
- Drug
- Lead sponsor
- Resolvyx Pharmaceuticals, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 232 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2009
- U.S. locations
- 1
- States / cities
- Andover, Massachusetts