A 1-Year Study in Multiple Clinics Testing Rebamipide Eye Drops for Dry Eye Compared With a Placebo
Public ClinicalTrials.gov record NCT00201981. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Rebamipide Ophthalmic Suspension in the Treatment of Dry Eye: A Multicenter, Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, 52 Week Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine the potential safety and effectiveness of rebamipide eye drops, an investigational eye drop being developed for the treatment of keratoconjunctivitis sicca (dry eye).
Study identification
- NCT ID
- NCT00201981
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 755 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 1, 2004 (Actual)
- Primary completion
- Feb 1, 2007 (Actual)
- Completion
- Feb 1, 2007 (Actual)
- Last update posted
- Jun 15, 2026
2004 – 2007
United States locations
- U.S. sites
- 63
- U.S. states
- 26
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Research Center, LLC | Birmingham | Alabama | 35209 | — |
| Sun Valley Arthritis Center, Ltd. | Glendale | Arizona | 85308 | — |
| Pivotel Research Center | Peoria | Arizona | 85381 | — |
| Hope research Institute | Phoenix | Arizona | 85006 | — |
| Buena Vista Eye Care Center | Phoenix | Arizona | 85012 | — |
| Radiant Research | Scottsdale | Arizona | 85251 | — |
| Sall Eye Research Center | Artesia | California | 90701-5653 | — |
| Radiant Research - Irvine | Irvine | California | 92618 | — |
| Scripps Clinic Medical Group, Inc. | La Jolla | California | 92037 | — |
| American Eye Institute | Los Angeles | California | 90048 | — |
| Eye Clinic of San Diego | San Diego | California | 92103 | — |
| Healthcare Partners Medical Group | Torrance | California | 90503 | — |
| Centennial Eye Associates | Centennial | Colorado | 80112 | — |
| Corneal Consultants of Colorado | Littleton | Colorado | 80120 | — |
| Western States Clinical Research, Inc. | Wheat Ridge | Colorado | 80033 | — |
| Peter C. Donshik, MDPC | Bloomfield | Connecticut | 06002 | — |
| Opticare Eye Health Center | Waterbury | Connecticut | 06708 | — |
| The Eye Associates | Bradenton | Florida | 34209 | — |
| Hernando Eye Institute | Brooksville | Florida | 34613 | — |
| Radiant Research, Inc. - Lake Worth | Lake Worth | Florida | 33461 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Eye Associates International | Ormond Beach | Florida | 32174 | — |
| Pinellas Eye Center | Pinellas Park | Florida | 33781 | — |
| Ft. Lauderdale Eye Institute | Sunrise | Florida | 33351 | — |
| Marvin E. Greenberg, MD PA 7 | Tamarac | Florida | 33321 | — |
| Clinical Research of West Florida, Inc. | Tampa | Florida | 33603 | — |
| International Eye Center | Tampa | Florida | 33603 | — |
| Omni Eye Services | Atlanta | Georgia | 30342 | — |
| University of Kentucky, Department of Ophthamology | Lexington | Kentucky | 40536-0293 | — |
| Kentucky Lions Eye Center | Louisville | Kentucky | 40222 | — |
| Gulf Coast Research Associates, Inc. | Baton Rouge | Louisiana | 70808 | — |
| Danial Long, MD | Gretna | Louisiana | 70056 | — |
| Lakeview Optical | New Orleans | Louisiana | 70124 | — |
| Eye Center Northeast | Bangor | Maine | 04401 | — |
| Krieger Eye Institute | Baltimore | Maryland | 21215 | — |
| The Wilmer Eye Institute | Lutherville | Maryland | 21093 | — |
| New England Eye Center | Boston | Massachusetts | 02111 | — |
| The Eye Institute - Lahey Clinic North | Peabody | Massachusetts | 01960 | — |
| Mississippi Eye Associates | Ocean Springs | Mississippi | 39564 | — |
| Montana Medical Research, LLC | Missoula | Montana | 59804 | — |
| Clinical Research Center of Nevada | Las Vegas | Nevada | 89104 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| Western New York Eye Center | Orchard Park | New York | 14127 | — |
| Glaucoma Consultants of the Capital Region | Slingerlands | New York | 12159 | — |
| Orellana Retina Associates, PLLC | Raleigh | North Carolina | 27612 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106-5068 | — |
| Comprehensive Opthalmology & Optical Services | Cleveland | Ohio | 44115 | — |
| Clinical Research Source, Inc. | Perrysburg | Ohio | 43551 | — |
| Clinical Research Institute of Southern Oregon | Medford | Oregon | 97504 | — |
| Northwest Corneal Services | Portland | Oregon | 97223 | — |
| Vision Surgery and Laser Center | Roseburg | Oregon | 97470 | — |
| West Hills Vision Center | Moon Township | Pennsylvania | 15108 | — |
| Glaucoma Consultants and Center for Eye Research | Mt. Pleasant | South Carolina | 29464 | — |
| University Eye Surgeons | Maryville | Tennessee | 37803 | — |
| St. Luke's Eye Institute | Amarillo | Texas | 79106 | — |
| Eye Clinic of Austin | Austin | Texas | 78731 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Surgical Eye Associates, PA | Houston | Texas | 77055 | — |
| Brazosport Eye Institute | Lake Jackson | Texas | 77566 | — |
| Axia Research | Salt Lake City | Utah | 84107 | — |
| John Moran Eye Center, University of Utah | Salt Lake City | Utah | 84132 | — |
| Physicians Research Options, LC | Sandy City | Utah | 84070 | — |
| Access Eye Research Center | Fredericksburg | Virginia | 22405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00201981, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 15, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00201981 live on ClinicalTrials.gov.