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ClinicalTrials.gov public records Last synced Jun 27, 2026, 11:50 AM EDT

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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Keratomileusis, Laser In Situ Clear all
Withdrawn No phase listed Observational Accepts healthy volunteers

The Role of Psychosocial and Other Quality of Life Parameters in Evaluating Functional Changes Prior to and Following Laser In-situ Keratomileusis (LASIK)Changes Laser In-situ Keratomileusis (LASIK)

NCT00344604
View directory record Official record
Conditions
Keratomileusis, Laser In Situ
Interventions
Role of psychosocial and quality of life parameters prior to and following LASIK.
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Mixed Astigmatism

NCT00761826
View directory record Official record
Conditions
Mixed Astigmatism
Interventions
MEL 80 Mixed Astigmatism Treatment
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
5
States / cities
San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CONTOURA vs WFO Ablation PRK & LASIK

NCT05037370
View directory record Official record
Conditions
Refractive Surgery
Interventions
Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
21 Years to 50 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jun 27, 2026, 11:50 AM EDT
No Longer Available No phase listed Expanded access Accepts healthy volunteers

Progressive Keratoconus or Ectasia Treatment Plan

NCT01384773
View directory record Official record
Conditions
Keratoconus, Ectasia
Interventions
Riboflavin Solution, UV-X Illumination System
Other · Device
Lead sponsor
Stephen Trokel
Other
Eligibility
16 Years and older
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Jun 27, 2026, 11:50 AM EDT
Terminated Not applicable Interventional Results available

Topo-guided LASIK and Photorefractive Keratectomy vs Wavefront LASIK and Photorefractive Keratectomy

NCT03075176
View directory record Official record
Conditions
Surgery, Myopia
Interventions
Wavefront optimized LASIK, Wavefront optimized Photorefractive Keratectomy, Topography-guided LASIK, Topography-guided Photorefractive Keratectomy
Device
Lead sponsor
University of Utah
Other
Eligibility
21 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jul 16, 2023 · Synced Jun 27, 2026, 11:50 AM EDT
Active, not recruiting Not applicable Interventional

Safety and Effectiveness of the TENEO 317 Model 2 (1.28 US) Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Hyperopia With or Without Astigmatism

NCT05264623
View directory record Official record
Conditions
Hyperopia
Interventions
TENEO 317 Model 2 excimer laser
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
22 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
9
States / cities
Newport Beach, California • Fort Myers, Florida • Bloomington, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

NCT02701764
View directory record Official record
Conditions
Dry Eye
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Results available

A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism

NCT04111757
View directory record Official record
Conditions
Myopia, Myopic Astigmatism
Interventions
Technolas® TENEO 317 Model 2
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
22 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
10
States / cities
Newport Beach, California • Blaine, Minnesota • Bloomington, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK

NCT00411827
View directory record Official record
Conditions
Keratoconjunctivitis Sicca
Interventions
PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
Procedure
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
21 Years to 40 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients

NCT00598689
View directory record Official record
Conditions
Corneal Epithelium Defect
Interventions
0.3% hypromellose
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 6, 2016 · Synced Jun 27, 2026, 11:50 AM EDT
Completed No phase listed Observational

Patient Reported Outcomes With LASIK: PROWL-2

NCT01655420
View directory record Official record
Conditions
Laser in Situ Keratomileusis
Interventions
LASIK
Procedure
Lead sponsor
Food and Drug Administration (FDA)
Federal
Eligibility
21 Years to 84 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
5
States / cities
Stanford, California • Indianapolis, Indiana • Overland Park, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Comparison of LASIK and SBK

NCT00714363
View directory record Official record
Conditions
Myopia
Interventions
LASIK, SBK
Procedure
Lead sponsor
University of Utah
Other
Eligibility
21 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 18, 2010 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Moderate to High Myopia

NCT00762541
View directory record Official record
Conditions
Myopia
Interventions
MEL 80 Treatment of High Myopia
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
5
States / cities
San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Completed No phase listed Observational

Long-term LASIK Follow up Study

NCT01695642
View directory record Official record
Conditions
Lasik Eye Surgery
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 99 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 2 Interventional Results available

Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)

NCT04630158
View directory record Official record
Conditions
Chronic Ocular Pain
Interventions
SAF312 Placebo, SAF312
Other · Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
24
States / cities
Mission Hills, California • Newport Beach, California • Palo Alto, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 4 Interventional

Mechanical vs. Alcohol Separation of the Corneal Epithelium During Surface Ablation Refractive Procedures

NCT00366808
View directory record Official record
Conditions
Keratomileusis, Laser In Situ
Interventions
LASIK surgery
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Completed No phase listed Observational

Patient-Reported Outcomes With LASIK:PROWL-1

NCT01526291
View directory record Official record
Conditions
Laser in Situ Keratomileusis
Interventions
Not listed
Lead sponsor
Food and Drug Administration (FDA)
Federal
Eligibility
21 Years to 84 Years
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia

NCT00762281
View directory record Official record
Conditions
Hyperopia
Interventions
MEL 80 Hyperopic LASIK Treatment
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
21 Years and older
Enrollment
189 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
6
States / cities
San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2012 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK)

NCT05082974
View directory record Official record
Conditions
Dry Eye Disease
Interventions
OC-01 (varenicline 0.6mg/ml) nasal spray, Placebo (vehicle) nasal spray
Drug
Lead sponsor
Vance Thompson Vision ND
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

IntraLase vs Hansatome Flaps in LASIK

NCT00691431
View directory record Official record
Conditions
Myopia
Interventions
LASIK
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2011 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Phase 2 Interventional Results available

Study of Cyclosporine in Post-LASIK Patients

NCT00991458
View directory record Official record
Conditions
Laser In Situ Keratomileusis
Interventions
Cyclosporine 0.010% eye drops, Cyclosporine 0.005% eye drops, Placebo (Vehicle for Cyclosporine)
Drug
Lead sponsor
Allergan
Industry
Eligibility
21 Years to 50 Years
Enrollment
621 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Jun 27, 2026, 11:50 AM EDT
Completed Not applicable Interventional Results available

70 vs 110 Degree Side-cut Angles in Femtosecond LASIK

NCT03122535
View directory record Official record
Conditions
Operative Incision
Interventions
FS-LASIK 70 degree side-cut angle, FS-LASIK 110 degree side-cut angle
Device
Lead sponsor
University of Utah
Other
Eligibility
21 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Jun 27, 2026, 11:50 AM EDT