Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:42 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Ketone Metabolism Clear all

Conditions: Bipolar Disorder
Interventions: Ketone Ester Beverage, Low Glycemic Index Diet; Dietary Supplement · Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan

Conditions: Type 1 Diabetes Mellitus, Exercise Physiology
Interventions: Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT), Continuous Glucose Monitoring, Continuous Ketone Monitoring; Behavioral · Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Diabetes Mellitus, Ketosis, Diabetic
Interventions: Ketone; Diagnostic Test
Lead sponsor: Nova Biomedical; Industry
Eligibility: 18 Years and older
Enrollment: 173 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Medley, Florida

Conditions: Type 1 Diabetes, Hypoglycemia
Interventions: Beta-hydroxybutyrate, Normal Saline; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Evaluate Ketogenic Stress
Interventions: Exenatide/Exenatide extended release, Dapagliflozin, Placebo; Drug
Lead sponsor: University at Buffalo; Other
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Williamsville, New York

Conditions: Type 1 Diabetes (T1D)
Interventions: Temporary Insulin Suspension, Glucose and ketone sensor; Behavioral · Device
Lead sponsor: Mahla Poudineh; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Ketosis
Interventions: Ketone Supplement, Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale, Blood Draw, Urine Analysis; Dietary Supplement · Behavioral · Biological + 1 more
Lead sponsor: Ohio State University; Other
Eligibility: 20 Years to 70 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Novato, California • Columbus, Ohio

Conditions: Obesity, Appetite, Healthy Volunteers
Interventions: Not listed
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Parkinson Disease, Ketosis
Interventions: Ketone Ester Elite endurance Nutrition Drink, Stool Sample; Dietary Supplement · Other
Lead sponsor: University of Florida; Other
Eligibility: 40 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
Interventions: Kenetik; Ketone Concentrate, Isocaloric dextrose placebo; Dietary Supplement
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Wernersville, Pennsylvania

Conditions: Heart Failure, Type 2 Diabetes Mellitus
Interventions: Beta-hydroxy-butyrate; Drug
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 80 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: San Antonio, Texas

Conditions: Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
Interventions: Exogenous Ketone Drink, Placebo; Dietary Supplement
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: MELAS Syndrome, Mitochondrial Diseases
Interventions: Medium-Chain Triglycerides; Dietary Supplement
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: Not listed
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Ketosis, Alcohol Drinking, MRI
Interventions: Kenetik, Alcohol beverage; Dietary Supplement · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Metabolic Syndrome
Interventions: Ketone Ester Supplement, Placebo; Dietary Supplement · Other
Lead sponsor: University of Southern Mississippi; Other
Eligibility: 18 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Hattiesburg, Mississippi

Conditions: Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
Interventions: ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session, Placebo beverage; Dietary Supplement · Diagnostic Test
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Asthma, Obesity
Interventions: DGA Diet, MCT Diet, KETO Diet; Other
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Diabetic Cardiomyopathies, Heart Failure
Interventions: Probiotic; Dietary Supplement
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Metabolic Syndrome, Normal Cognition
Interventions: Ketone Ester drink, Placebo: isocaloric dextrose drink; Dietary Supplement
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 55 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Metabolic Syndrome
Interventions: Continuous Glucose Monitor, <Active Comparator?>; Device · Other
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 69 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Wesley Chapel, Florida

Conditions: Asthma
Interventions: DGA Diet, MCT Diet, KETO Diet; Other
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: PCOS (Polycystic Ovary Syndrome)
Interventions: Ketogenic diet, Exogenous Ketone Supplement; Other · Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Type 2 Diabetes, Ketone Body Metabolism, Ketones, Metabolism
Interventions: Ketone Ester Acute, Placebo Acute; Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis, Ketones
Interventions: Sotagliflozin initiation; Drug
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones

Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise

StatStrip Glucose/Ketone Meter System Ketone Evaluation

Brain Ketone Metabolism in Type 1 Diabetes

An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes

Feasibility Study of a Continuous Glucose-Ketone Monitoring Device in People With Type 1 Diabetes

Variations in Ketone Metabolism

Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure

Effect of Ketone Esters in Parkinson's Disease

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1

Chronic Exogenous Ketosis in HFpEF

Ketones & Mitochondrial Heteroplasmy

Effects of Ketone Supplement and Alcohol on Brain Metabolism

Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

Nutrition for Asthmatics with Obesity

Diabetic Cardiomyopathy and Heart Failure

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older

Optimal Metabolic Health Through Continuous Glucose Monitoring

Nutrition for Asthmatics

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.