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Showing 1–24 of 109 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ketones Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Fast Bar on Intermittent Fasting

NCT04790552
View directory record Official record
Conditions
Fasting
Interventions
Dinner, Fasting, Fast Bar, Bar with Coffee, Bar with Tea
Other
Lead sponsor
L-Nutra Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Early Phase 1 Interventional

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

NCT06108076
View directory record Official record
Conditions
Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction
Interventions
Ketone Monoester (KE)
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

NCT07063732
View directory record Official record
Conditions
High Altitude Hypoxia, Exercise
Interventions
Ketone Monoester (KME), Placebo
Dietary Supplement
Lead sponsor
McMaster University
Other
Eligibility
18 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pharmacokinetics of C6 Ketone Di-ester

NCT05310058
View directory record Official record
Conditions
Pharmacokinetics
Interventions
C6 ketone di-ester
Dietary Supplement
Lead sponsor
BHB Therapeutics, Ireland LTD
Industry
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Early Phase 1 Interventional

Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders

NCT05411835
View directory record Official record
Conditions
Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency, Carnitine Palmitoyltransferase Deficiency 2, Very Long Chain Acyl Coa Dehydrogenase Deficiency, Trifunctional Protein Deficiency
Interventions
Nutritional Ketone Supplement, Isocaloric Placebo Supplement
Dietary Supplement
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Esters for Optimization of Operator Performance in Hypoxia

NCT07065864
View directory record Official record
Conditions
Hypoxia
Interventions
Ketone ester, Placebo
Dietary Supplement · Other
Lead sponsor
Florida Institute for Human and Machine Cognition
Other
Eligibility
18 Years and older · Male only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Pensacola, Florida
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Phase 1Phase 2 Interventional

Dietary Intervention With the Modified Atkins Diet in Stroke Rehabilitation

NCT01820663
View directory record Official record
Conditions
Stroke, Ischemic Stroke
Interventions
Modified Atkins Diet, Control diet
Other
Lead sponsor
Burke Rehabilitation Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tolerance and Safety of a Ketone-Promoting Food Ingredient

NCT04707989
View directory record Official record
Conditions
Tolerance
Interventions
Ketone- Promoting Food Ingredient #1, Ketone- Promoting Food Ingredient #2, Ketone Free Placebo
Other
Lead sponsor
BHB Therapeutics, Ireland LTD
Industry
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated May 9, 2021 · Synced Jun 10, 2026, 4:56 AM EDT
Enrolling by invitation Phase 2 Interventional

Ketones in Heart Failure With Reduced Ejection Fraction

NCT06195982
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
ketone ester, placebo
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of 14:10 Time-Restricted Eating on Body Weight and Metabolic Markers

NCT04492930
View directory record Official record
Conditions
Time Restricted Feeding
Interventions
14:10 Regimen, 12:12 Regimen
Behavioral
Lead sponsor
Jenny Craig, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

NCT05651243
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Ketone Ester Supplement, Placebo
Dietary Supplement · Other
Lead sponsor
University of Southern Mississippi
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of PK of Caprylic Triglyceride Oil, AC-1202, AC-1204, and Axona on Ketone Body Production

NCT02833012
View directory record Official record
Conditions
Healthy
Interventions
Caprylic Triglyceride Oil, AC-1202, Axona, AC-1204
Drug
Lead sponsor
Cerecin
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Effects of Ketone Supplement and Alcohol on Brain Metabolism

NCT06815237
View directory record Official record
Conditions
Ketosis, Alcohol Drinking, MRI
Interventions
Kenetik, Alcohol beverage
Dietary Supplement · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Enrolling by invitation Not applicable Interventional

Ketone and Hawthorn Extract Supplementation in Congestive Heart Failure

NCT07166965
View directory record Official record
Conditions
Congestive Heart Failure(CHF)
Interventions
Hawthorn supplement, Ketones, Placebo Control
Dietary Supplement · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Early Phase 1 Interventional

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

NCT05057806
View directory record Official record
Conditions
Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
Interventions
Empagliflozin 25 MG, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

StatStrip Glucose/Ketone Meter System Ketone Evaluation

NCT05118061
View directory record Official record
Conditions
Diabetes Mellitus, Ketosis, Diabetic
Interventions
Ketone
Diagnostic Test
Lead sponsor
Nova Biomedical
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Medley, Florida
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Not applicable Interventional

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

NCT07227363
View directory record Official record
Conditions
PCOS (Polycystic Ovary Syndrome)
Interventions
Ketogenic diet, Exogenous Ketone Supplement
Other · Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Active, not recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Effect of Nutritional Ketosis on Alcohol Metabolism

NCT06065657
View directory record Official record
Conditions
Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging, Alcohol Drinking
Interventions
Ketone Supplement, Control Diet, Ketogenic diet, Ethanol
Dietary Supplement · Other · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 50 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption

NCT06954675
View directory record Official record
Conditions
Microbiome Analysis
Interventions
Exogenous ketone ester
Dietary Supplement
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers

NCT05662865
View directory record Official record
Conditions
Ketones, Metabolism
Interventions
SGLT2 inhibitor, Controlled, Adaptive Study Diet
Drug · Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pharmacokinetics of Two Fatty Acid Ketone Esters

NCT05686083
View directory record Official record
Conditions
Pharmacokinetics
Interventions
C6 ketone di-ester, Novel ketone di-ester
Dietary Supplement
Lead sponsor
BHB Therapeutics, Ireland LTD
Industry
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Jun 10, 2026, 4:56 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Method Comparison/User Evaluation of the i-SENS Self-Monitoring Blood Glucose / β-Ketone System

NCT05833100
View directory record Official record
Conditions
Diabetes
Interventions
CareSens PRO GK Blood Glucose/b-Ketone Monitoring system
Device
Lead sponsor
i-SENS, Inc.
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Renton, Washington
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Exogenous Ketones on Cognitive Function

NCT07051655
View directory record Official record
Conditions
Placebo - Control, Ketone Monoester
Interventions
Ketone Monoester (KE), Placebo
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jun 10, 2026, 4:56 AM EDT
Recruiting Phase 1Phase 2 Interventional

Beta-Hydroxybutyrate Feasibility Treating IBD

NCT06351124
View directory record Official record
Conditions
Crohn's Disease, Inflammatory Bowel Diseases
Interventions
Feasibility of beta-hydroxybutyrate supplementation to reduce inflammation in patients with Crohn's
Biological
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jun 10, 2026, 4:56 AM EDT