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Showing 1–24 of 884 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Knee Arthroplasty Clear all
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Use of Interferential Current (IFC) Therapy After Total Knee Arthroplasty

NCT04137731
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Interferential Current Therapy
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics for Subjects With Smith & Nephew Journey II BCS TKA, Journey II CR TKA, Or Journey II XR TKA

NCT04612036
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee
Interventions
Journey II Bi-Cruciate Stabilized TKA, Journey II Cruciate Retaining TKA, Journey II Bi-Cruciate Retaining TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

TSolution One® Total Knee Arthroplasty

NCT03017261
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TSolution One®
Device
Lead sponsor
Think Surgical Inc.
Industry
Eligibility
21 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
6
States / cities
Hackensack, New Jersey • New York, New York • Roslyn, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

NCT04786119
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI Robotics
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Morrisville, North Carolina • New Albany, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

A Comparative Analysis of Two Types of Exercise on Outcomes Following Total Knee Arthroplasty

NCT01545986
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Exercise
Behavioral
Lead sponsor
Helen Hayes Hospital
Other
Eligibility
60 Years to 89 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
West Haverstraw, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2012 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Regional Prophylactic Vancomycin in Revision Total Knee Replacement

NCT02020031
View directory record Official record
Conditions
Arthropathy of Knee Joint
Interventions
Vancomycin
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 24, 2016 · Synced Jul 20, 2026, 6:42 PM EDT
Recruiting Phase 1Phase 2 Interventional

Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

NCT07672301
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
Combination Product · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Not yet recruiting Not applicable Interventional

The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty

NCT07219329
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Weighted Blanket
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

A Randomized Prospective Trial of Total Knee Arthroplasty Options Comparing Standard Knee Cutting Guides and MRI Generated Patient Specific Custom Cutting Guides

NCT01072019
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Instrument
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Regenexx™ SD Versus Exercise Therapy for Treatment of Knee Osteoarthritis With Historical Comparison to TKA

NCT02034032
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Regenexx SD, Exercise Therapy
Procedure · Behavioral
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Des Plaines, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 3, 2019 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Early Phase 1 Interventional

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

NCT02740192
View directory record Official record
Conditions
Pain
Interventions
Adductor Canal Block, Periarticular Injection, Ropivacaine, Bupivacaine
Procedure · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 29, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Phase 1 Interventional

Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement

NCT00454298
View directory record Official record
Conditions
Osteoarthritis
Interventions
AGG-523 (Aggrecanase Inhibitor)
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
5
States / cities
Boston, Massachusetts • Newton, Massachusetts • Winchester, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2009 · Synced Jul 20, 2026, 6:42 PM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 21, 2016 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA

NCT02730728
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Post Operative Pain Control
Interventions
20ml bolus of 0.5% ropivicaine, 0.2% Ropivicaine at 8 milliliter/hour, 5ml bolus of 0.5% ropivicaine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Jul 20, 2026, 6:42 PM EDT
Terminated Phase 3 Interventional Results available

Trial of Prophylactic Tamsulosin for Postoperative Urinary Retention in Primary Total Hip and Knee Arthroplasty Patients

NCT02518971
View directory record Official record
Conditions
Postoperative Urinary Retention
Interventions
Tamsulosin, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
35 Years and older · Male only
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Hypnosis for Symptom Management in Elective Orthopedic Surgery

NCT03308071
View directory record Official record
Conditions
Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain, Postoperative Complications
Interventions
Hypnosis
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2021 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Phase 4 Interventional Results available

Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty

NCT01809054
View directory record Official record
Conditions
Primary Total Hip and Knee Arthroplasty
Interventions
Arixtra, Pneumatic compression stockings, Aspirin
Drug · Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 20, 2014 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Progressive Rehabilitation Following Total Knee Arthroplasty

NCT01537328
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total knee replacement rehabilitation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jul 20, 2026, 6:42 PM EDT
Terminated Phase 4 Interventional

Cardiac and Renal Biomarkers in Arthroplasty Surgery

NCT03940651
View directory record Official record
Conditions
Renal Injury, Anesthesia, Myocardial Injury, Arthropathy of Knee, Arthropathy of Hip
Interventions
Spinal Anesthesia, General Anesthetics
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Jul 20, 2026, 6:42 PM EDT
Completed No phase listed Observational Results available

A Retrospective Study of the iTotal CR Knee Replacement System

NCT01564654
View directory record Official record
Conditions
Osteoarthritis
Interventions
iTotal KRS
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
4
States / cities
La Quinta, California • Boynton Beach, Florida • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Movement Pattern Biofeedback Training After Total Knee Arthroplasty

NCT03325062
View directory record Official record
Conditions
Total Knee Arthroplasty, Older Adults
Interventions
Control, Experimental: MOVE
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Jul 20, 2026, 6:42 PM EDT
Completed No phase listed Observational Results available

Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)

NCT04321356
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee
Interventions
Triathlon PCR TKA, Triathlon PS TKA, Persona PCR TKA, Persona PS TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Recruiting Not applicable Interventional

Sleep TO Prevent Post-surgical Pain

NCT06976138
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device, Sleep / Knee Osteoarthritis Education
Behavioral · Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Jul 20, 2026, 6:42 PM EDT