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Showing 1–24 of 812 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Knee Arthroplasty, Total Clear all
Completed No phase listed Observational

An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arthroplasty

NCT03071250
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis, Knee Arthritis, Hip Arthritis
Interventions
Total knee or Hip Arthroplasty
Procedure
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Sep 1, 2026, 5:57 PM EDT
Completed No phase listed Observational

Prospective, Multiconfiguration Study to Assess Functional Performance of Primary Total Knee Arthroplasty System

NCT01746524
View directory record Official record
Conditions
Osteoarthritis
Interventions
ATTUNE Primary Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
1,138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
9
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional Results available

Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty

NCT01301950
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Custom Patient Instrumentation, Conventional Instruments
Other
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Mooresville, Indiana • Bartlesville, Oklahoma • Reston, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Traditional vs Oral Fluid Management in Total Knee Arthroplasty

NCT03719378
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Pre Operative Oral Fluids
Other
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting Phase 4 Interventional

Evaluation of Pain Treatment After Total Knee Arthroplasty

NCT07538570
View directory record Official record
Conditions
Pain
Interventions
Suzetrigine, Placebo
Drug
Lead sponsor
Vertex Pharmaceuticals Incorporated
Industry
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bellaire, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional Results available

Use of Interferential Current (IFC) Therapy After Total Knee Arthroplasty

NCT04137731
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Interferential Current Therapy
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional

Effects of tDCS Combined With CBI on Postsurgical Pain

NCT04199780
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Interventions
Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 90 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting Not applicable Interventional

Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

NCT06768762
View directory record Official record
Conditions
Knee Replacement
Interventions
Phone Coaching, Progress reports to providers, 'Hear from Others' Videos, Individualized Feedback, Online exercise program
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting Not applicable Interventional

Binaural Beats for Postoperative Pain and Anxiety Reduction

NCT07437469
View directory record Official record
Conditions
TKA, THA, Anxiety, Binaural Beats, Music Exposure, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Total Knee Replacement, Total Hip Replacement
Interventions
Binaural Beats Audio Intervention, Music of Choice
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Terminated Not applicable Interventional Results available

Efficacy of AposTherapy® in Knee OA

NCT03153956
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Calibrated AposTherapy®, Non-Calibrated Sham Apos Therapy Device
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
45 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

NCT04269239
View directory record Official record
Conditions
Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Healthy Habits, Sleep Habits
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Galveston, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Phase 4 Interventional Results available

EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty

NCT02255500
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine FNB, EXPAREL Infiltration
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2021 · Synced Sep 1, 2026, 5:57 PM EDT
Not listed Not applicable Interventional

Long-Term Multicenter Evaluation of the E1® Tibial Bearing

NCT01374230
View directory record Official record
Conditions
Osteoarthritis of the Knee, Traumatic Arthritis of the Knee
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 75 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2018 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Phase 3 Interventional Results available

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

NCT05139030
View directory record Official record
Conditions
Knee Osteoarthritis, Pain Management
Interventions
bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
6
States / cities
Little Rock, Arkansas • Pasadena, California • Dayton, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 1, 2026, 5:57 PM EDT
Terminated Not applicable Interventional

Nerve Burial for Preventing Neuralgia After Total Knee Arthroplasty

NCT02885467
View directory record Official record
Conditions
Neuralgia, Osteoarthritis of the Knee
Interventions
Total knee arthroplasty with Saphenous nerve burial, Standard total knee arthroplasty
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2018 · Synced Sep 1, 2026, 5:57 PM EDT
Not listed No phase listed Observational

Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements

NCT00958945
View directory record Official record
Conditions
Total Knee Arthroplasty, Arthroplasty, Replacement, Hip
Interventions
Not listed
Lead sponsor
Desert Orthopedic Center Medical Research Foundation
Other
Eligibility
18 Years to 95 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Rancho Mirage, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2009 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting No phase listed Observational

A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System

NCT05653102
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Truliant Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
5
States / cities
Aurora, Colorado • DeLand, Florida • Las Vegas, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting Not applicable Interventional

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

NCT07191067
View directory record Official record
Conditions
Pain
Interventions
Percutaneous radiofrequency electrical nerve stimulation, Non-therapeutic stimulation
Device
Lead sponsor
Synaptrix, Inc.
Industry
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Daphne, Alabama • Williamsville, New York • Chapel Hill, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Flexibility of Cognition And Persistent Pain

NCT02579538
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional

Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

NCT04910048
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions
POPOP (preoperative patient optimization program), SOC (standard of care)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Phase 4 Interventional

Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial

NCT03283878
View directory record Official record
Conditions
Arthropathy of Knee, Antibiotic Prophylaxis
Interventions
Cefazolin
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,770 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
14
States / cities
San Francisco, California • Atlanta, Georgia • Towson, Maryland + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 1, 2026, 5:57 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study

NCT02633085
View directory record Official record
Conditions
Osteoarthritis
Interventions
Fixed Bearing or Mobile Bearing UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Leesburg, Florida
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 1, 2026, 5:57 PM EDT
Completed Not applicable Interventional Results available

Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty

NCT01505374
View directory record Official record
Conditions
Difference Between Femoral Nerve Block and Saphenous Block
Interventions
Study Technique, Control Technique
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2022 · Synced Sep 1, 2026, 5:57 PM EDT
Recruiting Not applicable Interventional

Optimizing Pain Self-Management in Total Knee Arthroplasty

NCT06038240
View directory record Official record
Conditions
Osteo Arthritis Knee, Knee Pain Chronic, Surgery
Interventions
Savoring Meditation, Pain Self-Management and Education
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 1, 2026, 5:57 PM EDT