Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:54 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 1,218 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Knee Osteoarthritis Clear all

Conditions: Osteoarthritis
Interventions: celecoxib, Oxycodone, placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 2
States / cities: Palo Alto, California • Stanford, California

Conditions: Osteoarthritis (OA) of the Knee
Interventions: TPX-100 200mg, Once weekly for 4 weeks, PBS; Drug · Other
Lead sponsor: OrthoTrophix, Inc; Industry
Eligibility: 50 Years to 80 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 33
States / cities: Scottsdale, Arizona • Tucson, Arizona • Carrolton, California + 26 more

Conditions: Osteoarthritis
Interventions: CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg, CR845 5 mg; Drug
Lead sponsor: Cara Therapeutics, Inc.; Industry
Eligibility: 25 Years and older
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 5
States / cities: Omaha, Nebraska • Las Vegas, Nevada • Greensboro, North Carolina + 2 more

Conditions: Osteoarthritis, Knee
Interventions: acupuncture; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years to 70 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Knee Osteoarthritis, Osteo Arthritis Knee
Interventions: Microfragmented Adipose Tissue derived using the Lipogems® System, Saline Injection; Device · Drug
Lead sponsor: Lipogems International spa; Industry
Eligibility: 18 Years and older
Enrollment: 173 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 16
States / cities: Phoenix, Arizona • Encinitas, California • La Mesa, California + 13 more

Conditions: Osteoarthritis, Knee
Interventions: Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit; Procedure · Device
Lead sponsor: Millennium Pain Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 3
States / cities: Bloomington, Illinois • Decatur, Illinois • Peoria, Illinois

Conditions: Osteoarthritis
Interventions: onabotulinumtoxinA, Normal Saline; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Artesia, California

Conditions: Osteoarthritis, Knee
Interventions: RAPTOR protocol: hybrid in-person + telehealth physical therapy services; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 40 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Osteoarthritis, Knee
Interventions: MISHA Knee System, Non-Surgical Treatment; Device · Other
Lead sponsor: Moximed; Industry
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 9
States / cities: Davis, California • Oceanside, California • Sacramento, California + 6 more

Conditions: Knee Osteoarthritis
Interventions: High Intensity Strength Training, Low Intensity Strength Training, Attention Control; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 50 Years and older
Enrollment: 377 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Osteo Arthritis Knee
Interventions: Ropivacaine; Drug
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Knee Pain Chronic, Osteo Arthritis Knee
Interventions: HB-adMSC; Biological
Lead sponsor: Hope Biosciences Research Foundation; Industry
Eligibility: Not listed
U.S. locations: 1
States / cities: Sugar Land, Texas

Conditions: Osteoarthritis of the Knee, Coagulopathy
Interventions: Pennsaid; Drug
Lead sponsor: Nathan Wei, MD, FACP, FACR:; Other
Eligibility: 55 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Frederick, Maryland

Conditions: Total Knee Arthroplasty (TKA)
Interventions: Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments; Behavioral · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 4
States / cities: Gainesville, Florida

Conditions: Osteoarthritis, Knee
Interventions: Hylan F- 20; Drug
Lead sponsor: Steadman Hawkins Research Foundation; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Vail, Colorado

Conditions: Knee Osteoarthritis
Interventions: Pure PRP II, PureBMC; Combination Product
Lead sponsor: Andrews Research & Education Foundation; Other
Eligibility: 18 Years to 80 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Gulf Breeze, Florida

Conditions: Osteoarthritis, Knee, Knee Replacement
Interventions: Mindfulness-based Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 45 Years to 100 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Degenerative Joint Disease, Osteoarthritis
Interventions: PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel; Device
Lead sponsor: Medtronic Surgical Technologies; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: Rochester Hills, Michigan • Arlington, Texas

Conditions: Osteoarthritis
Interventions: Dextrose Prolotherapy, Saline Prolotherapy, At-home physical therapy exercise group; Procedure · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 40 Years to 70 Years
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2016
U.S. locations: 2
States / cities: Madison, Wisconsin

Conditions: Osteoarthritis of the Knee
Interventions: Lorecivivint; Drug
Lead sponsor: Biosplice Therapeutics, Inc.; Industry
Eligibility: 40 Years to 80 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 4
States / cities: Tucson, Arizona • Winter Park, Florida • Oak Brook, Illinois + 1 more

Conditions: Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis
Interventions: Subchondroplasty with Arthroscopy, Arthroscopy Alone; Procedure
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 30 Years to 75 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 12
States / cities: Encinitas, California • Loma Linda, California • Stanford, California + 9 more

Conditions: Osteoarthritis
Interventions: Shock Absorbing Insole (SofSole Athletes Plus); Other
Lead sponsor: Winston Salem State University; Other
Eligibility: 50 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Osteoarthritis
Interventions: periosteal electro-acupuncture (osteopuncture).; Device
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 65 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Chronic Low Back Pain, Osteoarthritis
Interventions: Fasinumab, Placebo; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 56
States / cities: Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 47 more

Search by objective public record fields.

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee

A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee

An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect

Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis

Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain

BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis

Rural Access to Physical Therapy for Osteoarthritis Rehabilitation - Pilot

MOTION Clinical Trial

Strength Training for ARthritis Trial

High Versus Low Adductor Canal Block

Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain.

Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants

Total Knee Arthroplasty Biomechanics

Outcome Following Hylan F- 20 (Synvisc) + Corticosteroid Injections for the Treatment of Osteoarthritis of the Knee

Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

Prediction of Outcomes Following Total Knee Replacement- Pilot

PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

Joint Injections for Osteoarthritic Knee Pain

3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis

Subchondroplasty® Knee RCT

Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis

Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee