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ClinicalTrials.gov public records Last synced Nov 14, 2026, 1:31 AM EST

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Showing 1–24 of 82 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Knee Prosthesis Clear all

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: direct EMG controlled prosthetic ankle, PT guided prosthetic training; Device · Behavioral
Lead sponsor: North Carolina State University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Transfemoral Amputation
Interventions: MIT Powered Leg; Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 18 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Post-Meniscectomy Pain Syndrome, Osteoarthritis, Knee
Interventions: NUsurface® Meniscus Implant; Device
Lead sponsor: Phoenix Kinetics; Industry
Eligibility: 30 Years to 75 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2024
U.S. locations: 13
States / cities: Phoenix, Arizona • La Mesa, California • Long Beach, California + 10 more

Conditions: Implants
Interventions: Not listed
Lead sponsor: GE Healthcare; Industry
Eligibility: 18 Years to 85 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Waukesha, Wisconsin

Conditions: Prosthetic Joint Infection, Debridement With Prosthesis Retention, Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Suture
Interventions: VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial), Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament; Device
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 89 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Knee Prosthesis, Knee Arthroplasty
Interventions: DePuy fixed-bearing Total Condylar III (TC3) TKA, DePuy PFC Rotating Platform TC3 TKA; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 40 Years to 85 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 3
States / cities: Denver, Colorado • Knoxville, Tennessee

Conditions: Transfemoral Amputees
Interventions: Medial thighplasty with or without thigh liposuction; Procedure
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Unicompartmental Knee Arthroscopy
Interventions: DePuy Sigma HP Partial Knee; Device
Lead sponsor: Mississippi Sports Medicine and Orthopaedic Center; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Amputation of Knee, Back Pain, Osteo Arthritis Knee
Interventions: Haptic Biofeedback from SageMotion Biofeedback System; Device
Lead sponsor: San Jose State University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Palo Alto, California • San Francisco, California

Conditions: Osteoarthritis
Interventions: iUni® Unicompartmental Knee Resurfacing Device; Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2023
U.S. locations: 8
States / cities: Little Rock, Arkansas • La Quinta, California • Monterey, California + 5 more

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Stereotactic guidance system; Device
Lead sponsor: Ormonde M. Mahoney, MD; Other
Eligibility: 45 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Unilateral Traumatic Amputation, Amputation, Traumatic
Interventions: Powered ankle prosthesis, Dynamic Response Foot; Device
Lead sponsor: Deanna H Gates; Other
Eligibility: 21 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Arthroplasty Replacement Knee, Knee Prosthesis
Interventions: Subjects implanted with DePuy LCS PS RP TKA, Subjects implanted with DePuy Sigma PS RP TKA; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 20 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 4
States / cities: Denver, Colorado • Knoxville, Tennessee

Conditions: Prosthesis User, Amputation
Interventions: Power Knee; Device
Lead sponsor: Össur Iceland ehf; Industry
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Silver Spring, Maryland • Boston, Massachusetts

Conditions: Lower Extremity Amputation
Interventions: Torsionally adaptive prosthesis with 0:1 coupling ratio, Torsionally adaptive prosthesis with 1:6 coupling ratio, Torsionally adaptive prosthesis with 1:4 coupling ratio, Torsionally adaptive prosthesis with 1:3 coupling ratio, Torsionally adaptive prosthesis with 1:2 coupling ratio; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Hypothermia
Interventions: Observation Of Temperature; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: Restor3D; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 2
States / cities: Knoxville, Tennessee • Nashville, Tennessee

Conditions: Lower Limb Amputation Below Knee
Interventions: As-prescribed stiffness, Two categories stiffer than the as-prescribed stiffness, Two categories less stiff than the as-prescribed stiffness; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 70 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Osteoarthritis
Interventions: Total and Unicompartment Knee Replacement; Device
Lead sponsor: Medacta USA; Industry
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Leesburg, Florida

Conditions: Osteoarthritis, Arthritis, Rheumatoid, Avascular Necrosis of Bone, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions: Total knee replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 4
States / cities: La Jolla, California • Crystal River, Florida • Melbourne, Florida + 1 more

Conditions: Arthrofibrosis of Knee
Interventions: Low-Dose External Beam Irradiation, Hinged Revision Total Knee Arthroplasty; Radiation · Procedure
Lead sponsor: Mount Sinai Hospital, Canada; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Los Angeles, California • Salt Lake City, Utah

Conditions: Knee Prosthesis, Knee Replacement Arthroplasty
Interventions: Sigma Posterior Stabilizing Rotating Platform TKA Beaded Poly; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 40 Years to 85 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 3
States / cities: Denver, Colorado • Knoxville, Tennessee

Conditions: Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions: Klassic Knee System; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
Interventions: Smart Knee Implant; Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Restoration of Normative Postural Control

Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

The SUN Clinical Trial (Safety Utilizing NUsurface Meniscus Implant)

MRI Scanning of People With MR Safe Orthopedic Implants That Are Made of Metal

Antibiotic-coated Braided Suture Study

Comparison of Kinematics for Subjects Implanted With a PFC Sigma Rotating Platform or Fixed Bearing TC3 Prosthesis

Thigh Reduction Surgery of Above Knee Amputee Residual Limbs to Improve Prosthesis Fit and Patient Outcomes

A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis

Biofeedback Retention in Individuals With AKA

Multi-Center Study to Evaluate the ConforMIS iUni Knee Implant

Total Knee Arthroplasty Guidance Systems Study

Determining the Potential Benefit of Powered Prostheses

In Vivo Determination of 3D Patellofemoral Mechanics

Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic

Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation

Observational Examination of Thermoregulation in Total Joint Arthroplasty

Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study

Primary TKA Cruciate Retaining vs Cruciate Substituting With Rotating Platform Knee Prostheses

Stiffness and Low Dose Irradiation RCT

Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA

In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)

Investigating Patient Satisfaction With Smart Knee Implants