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ClinicalTrials.gov public records Last synced Nov 14, 2026, 12:49 PM EST

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Showing 49–72 of 82 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Knee Prosthesis Clear all

Conditions: Prosthesis User, Amputation
Interventions: NAVii; Device
Lead sponsor: Össur Iceland ehf; Industry
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 3
States / cities: Merrillville, Indiana • Bay City, Michigan • Perrysburg, Ohio

Conditions: Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions: Caesar Foot; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Other and Unspecified Complications of Amputation Stump
Interventions: Otto Bock C-Leg, Otto Bock Genium; Device
Lead sponsor: Jason Highsmith; Other
Eligibility: 18 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Total Knee Anthroplasty
Interventions: Intra-articular injection of bupivacaine in the knee joint, intra-articular injection of Exparel in the knee joint, Zynrelef; Drug
Lead sponsor: Foundation for Orthopaedic Research and Education; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Lower Extremity Amputation
Interventions: Caregiver socket, Prosthetist socket; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Lower Limb Amputation Above Knee (Injury)
Interventions: Microprocessor Knee (MPK), Non-Microprocessor Knee (NMPK); Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 55 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Total Knee Arthroplasty, Osteoarthritis
Interventions: NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 189 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 8
States / cities: Milford, Delaware • Chicago, Illinois • Rockford, Illinois + 5 more

Conditions: Complications; Arthroplasty
Interventions: Conformis CR Total Knee Replacement, Off the Shelf; Device
Lead sponsor: Restor3D; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Knoxville, Tennessee

Conditions: Infection of Total Hip Joint Prosthesis
Interventions: Prevena Incision Management System; Device
Lead sponsor: ProMedica Health System; Other
Eligibility: 18 Years to 85 Years
Enrollment: 248 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Toledo, Ohio

Conditions: Prosthesis User, Amputation
Interventions: RHEO KNEE XC; Device
Lead sponsor: Össur Iceland ehf; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 4
States / cities: Orlando, Florida • Flowood, Mississippi • Fort Worth, Texas + 1 more

Conditions: Transfemoral Amputees
Interventions: Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions: ICE Condition, Sham Condition; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Holliston, Massachusetts • Minneapolis, Minnesota

Conditions: Transfemoral Amputation, Limb Loss, Limb Absence
Interventions: Powered prosthetic knee joint, Conventional microprocessor-controlled prosthetic knee joint; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 45 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
Interventions: Cemented Tibia, Cementless Tibia; Procedure
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 70 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease, Musculoskeletal Disease, Prosthesis-Related Infections, Infection, Postoperative Complications, Pathologic Processes
Interventions: Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing; Device
Lead sponsor: KCI USA, Inc; Industry
Eligibility: 22 Years and older
Enrollment: 294 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 17
States / cities: Weston, Florida • Tucker, Georgia • New Orleans, Louisiana + 10 more

Conditions: Osteoarthritis
Interventions: Off the Shelf Total Knee Replacement, ConforMIS iTotal Knee Replacement; Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 215 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 8
States / cities: La Jolla, California • San Diego, California • Parker, Colorado + 5 more

Conditions: Amputation, Prosthesis User
Interventions: Xtremity Polymer Prosthetic Socket; Device
Lead sponsor: Medical Creations, Inc.; Industry
Eligibility: 19 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Prosthesis Related Infections
Interventions: [124I]FIAU; Radiation
Lead sponsor: BioMed Valley Discoveries, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 3
States / cities: Little Rock, Arkansas • Baltimore, Maryland • Lake Success, New York

Conditions: Prosthetic Joint Infection of Knee
Interventions: Intervention 1: Alternating Magnetic Field Treatment, Intervention 2 - Sham Treatment, Debridement, Antibiotics, Implant Retention; Device · Procedure
Lead sponsor: Solenic Medical, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: New Albany, Ohio • Tulsa, Oklahoma

Conditions: Total Knee Arthroplasty
Interventions: Hydrocortisone, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 50 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions: Ossur Power Knee, Reboocon Intuy Knee; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Osteoarthritis of Knee
Interventions: Medacta GMK posterior stabilized prosthesis, Medacta GMK Sphere prosthesis; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Arthritis of Knee
Interventions: Not listed
Lead sponsor: Athens Orthopedic Clinic, P.A.; Other
Eligibility: 18 Years and older
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Athens, Georgia

Conditions: Prosthesis-Related Infections, Arthroplasty
Interventions: Betadine Lavage, Saline Lavage; Procedure
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 505 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 2
States / cities: Chicago, Illinois • Winfield, Illinois

Search by objective public record fields.

An Investigation on Function and Performance of a New Microprocessor Controlled Prosthetic Knee

Caesar Foot Take-Home Validation Testing

Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis

Smart Knee Evaluation of Exparel and Zynrelef in TKA Recovery

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

Comparative Effectiveness Between Microprocessor Knees and Non-Microprocessor Knees

A Study to Compare the NexGen CR and CR-Flex Knee Implants

In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant

Evaluating Advantages of Prevena After Hip and Knee Arthroplasty

An Investigation of Functional Improvements in the RHEO KNEE Compared to Hydraulic Microprocessor Controlled Knees (MPKs)

Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction

Socket Cooling Effectiveness Take Home Study

A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation

Total Knee Arthroplasty (TKA) Cemented Versus Cementless Tibial Prosthesis Study

Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty

A Multicenter Study to Evaluate Functional Outcome After Knee Replacement

Post Market Clinical Protocol - Xtremity Polymer Prosthetic Socket System

Biodistribution and Dosimetry Evaluation of [124I]FIAU

Sola2 AMF Knee System Added to Surgery and Antibiotics in Adults With Knee Implant Infection

Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty

Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

Stability of the Medial Pivot Total Knee Prosthesis

Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

Dilute Betadine Lavage in the Prevention of Postoperative Infection