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ClinicalTrials.gov public records Last synced Oct 13, 2026, 7:05 PM EDT

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Showing 337–360 of 861 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Knee Replacement Arthroplasty Clear all
Completed Not applicable Interventional Results available

Early Postoperative Compex Rehab NMES Use for Total Knee Arthroplasty Patients

NCT01844193
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Compex Rehab
Device
Lead sponsor
Orthopaedic Research Foundation
Other
Eligibility
45 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Greenwood, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block for Medial Compartment Knee Arthroplasty

NCT01818531
View directory record Official record
Conditions
Postoperative Analgesia, Medial Unicompartmental Knee Arthroplasty
Interventions
Adductor canal block, Lumbar plexus block
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Oct 13, 2026, 7:05 PM EDT
Enrolling by invitation Not applicable Interventional

Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty

NCT06203756
View directory record Official record
Conditions
Arthroplasties, Knee Replacement, Revision Arthroplasty
Interventions
Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex UC, Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex PS, Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex Revision
Device
Lead sponsor
Corin
Industry
Eligibility
Not listed
Enrollment
713 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2040
U.S. locations
6
States / cities
Flagstaff, Arizona • Middlebury, Connecticut • Rochester, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 13, 2026, 7:05 PM EDT
Recruiting Phase 2 Interventional

Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

NCT07020312
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Hip Arthroscopy
Interventions
Visualization training with neurofeedback, Standard post-surgical rehabilitation therapy
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Completed No phase listed Observational

A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

NCT03598829
View directory record Official record
Conditions
Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
Interventions
Tryptase, Serum test
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years to 100 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 13, 2026, 7:05 PM EDT
Terminated Not applicable Interventional

Dynamic Splinting After Total Knee Arthroplasty

NCT00857701
View directory record Official record
Conditions
Reduced Knee Flexion
Interventions
Knee Extension Dynasplint
Device
Lead sponsor
Dynasplint Systems, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 12, 2013 · Synced Oct 13, 2026, 7:05 PM EDT
Terminated Not applicable Interventional

Independent Exercise Compared With Formal Rehabilitation Following Primary Total Knee Replacement

NCT01826305
View directory record Official record
Conditions
Recovery Following Primary Total Knee Arthroplasty
Interventions
Formal Rehabilitation Therapy, Independent Exercise Cohort
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 13, 2026, 7:05 PM EDT
Not yet recruiting Not applicable Interventional

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

NCT07439666
View directory record Official record
Conditions
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
Interventions
NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Recruiting Not applicable Interventional

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

NCT06946368
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Not applicable Interventional

A Prospective, Randomized, Controlled Study Comparing Three Tibial Component Designs in Total Knee Arthoplasty

NCT00589147
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
The Zimmer NexGen Legacy Knee System, modular cemented tibia, The Zimmer NexGen Legacy Knee System, non-modular cemented tibia., The Zimmer NexGen Legacy Knee System, non-modular uncemented tibia
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years to 85 Years
Enrollment
397 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2012 · Synced Oct 13, 2026, 7:05 PM EDT
Completed No phase listed Observational

Multicenter Registry for Effectiveness Analysis of ActiveCare+S.F.T® Mobile Compression Device for Thrombosis Prevention in Hip and Knee Arthroplasty

NCT01984190
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
Not listed
Lead sponsor
Medical Compression Systems
Industry
Eligibility
18 Years and older
Enrollment
411 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
10
States / cities
Little Rock, Alaska • La Jolla, California • Menlo Park, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Not applicable Interventional Results available

Virtual vs. Traditional Physical Therapy Following Total Knee Replacement

NCT02914210
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Virtual physical therapy rehabilitation program, No intervention
Device · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Oct 13, 2026, 7:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training Following Total Knee Arthroplasty

NCT02763488
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
DelfiPTS tourniquet system, Standard physical therapy
Device · Other
Lead sponsor
San Antonio Military Medical Center
Federal
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2016 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 4 Interventional Results available

The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery

NCT00990288
View directory record Official record
Conditions
Blood Loss
Interventions
Hemostatic Matrix
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Oct 13, 2026, 7:05 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

NCT05823727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
SOLUGEL, Placebo
Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 2 Interventional

Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

NCT02081703
View directory record Official record
Conditions
Postsurgical Pain
Interventions
AYX1 Injection 660 mg / 6 mL, AYX1 Injection 1100 mg / 10 mL, Placebo Injection 6 mL, Placebo Injection 10 mL
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Sheffield, Alabama • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Oct 13, 2026, 7:05 PM EDT
Completed No phase listed Observational

Impact of Component Design and Fixation in Total Knee Arthroplasty

NCT03272178
View directory record Official record
Conditions
Arthroplasties, Knee Replacement
Interventions
Depuy total knee implant, Triathlon total knee implant
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 1, 2021 · Synced Oct 13, 2026, 7:05 PM EDT
Not yet recruiting Phase 4 Interventional

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty

NCT07097493
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Not applicable Interventional

Intraoperative VR for Older Patients Undergoing TKA

NCT04748549
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Virtual Reality Immersive Relaxation, Immersive Audio Experience, Sham Virtual Reality Experience
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 4 Interventional Results available

Evaluating Vitamin D3 Supplement on Post-Op Outcomes

NCT04177758
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Vitamin D, Control
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Not applicable Interventional

African American Preference for Knee Replacement: A Patient-Centered Intervention

NCT01851785
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Decision Aid (DA) Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
50 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Oct 13, 2026, 7:05 PM EDT
Completed Phase 3 Interventional Results available

A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty

NCT00745290
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine HCl, SKY0402
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
19
States / cities
Birmingham, Alabama • Mobile, Alabama • Montgomery, Alabama + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2013 · Synced Oct 13, 2026, 7:05 PM EDT
Terminated No phase listed Observational

I-beam and Cruciate Tibial Components Used in Total Knee Replacement

NCT00588783
View directory record Official record
Conditions
Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions
I-beam design, Cruciate design
Device
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Warsaw, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Oct 13, 2026, 7:05 PM EDT