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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: LPS Clear all
Completed No phase listed Observational Accepts healthy volunteers

Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease

NCT01155492
View directory record Official record
Conditions
Parkinson's Disease, Multiple System Atrophy
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jun 7, 2026, 9:09 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Immune Cell Response to Stimuli

NCT00397280
View directory record Official record
Conditions
Inflammation
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 65 Years
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 7, 2026, 9:09 PM EDT
Recruiting Phase 1Phase 2 Interventional

Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors

NCT06578624
View directory record Official record
Conditions
Solid Tumor
Interventions
SA53-OS (phase 1), SA53-OS (phase 2)
Drug
Lead sponsor
Lamassu Bio Inc
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Canton, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jun 7, 2026, 9:09 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II

NCT00643058
View directory record Official record
Conditions
Healthy
Interventions
LPS endotoxin
Biological
Lead sponsor
John Sundy
Other
Eligibility
18 Years to 40 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 15, 2013 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults

NCT02521779
View directory record Official record
Conditions
Endotoxemia
Interventions
Low-fat Treatment Meal, Saturated-fat Treatment Meal, N-3 fat Treatment Meal, N-6 fat Treatment Meal
Other
Lead sponsor
Iowa State University
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 12, 2015 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Results available

A Study to Compare the NexGen LPS and LPS-Flex Knee Implants

NCT00763386
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 80 Years
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2010
U.S. locations
14
States / cities
Birmingham, Alabama • Decatur, Georgia • Springfield, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2012 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Happy Gut Study - Fermented Vegetables and Cardiovascular Biomarkers

NCT04887662
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
Fermented vegetable
Other
Lead sponsor
University of North Florida
Other
Eligibility
35 Years to 64 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional

Vaccination of HIV-1 Infected Patients With Dendritic Cells in Addition to Antiretroviral Treatment - (DALIA Trial)

NCT00796770
View directory record Official record
Conditions
HIV
Interventions
Dendritic Cell Vaccine
Biological
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Jun 7, 2026, 9:09 PM EDT
Terminated Phase 2 Interventional Results available

ATX-101 in Advanced Dedifferentiated Liposarcoma and Leiomyosarcoma

NCT05116683
View directory record Official record
Conditions
Leiomyosarcoma, Liposarcoma
Interventions
ATX-101
Drug
Lead sponsor
Benjamin Izar
Other
Eligibility
18 Years to 99 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of a 10,000 EU Dose of Endotoxin in Allergic and Mildly Asthmatic Adults

NCT00839189
View directory record Official record
Conditions
Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, Asthma
Interventions
Clinical Center Reference Endotoxin (CCRE)
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2009 · Synced Jun 7, 2026, 9:09 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Endoscopic Resection of Large Colorectal Polyps: An Observational Cohort Study

NCT04220905
View directory record Official record
Conditions
Colonic Polyp, Colonoscopy, Complication, Recurrence, Duodenal Polyp
Interventions
Not listed
Lead sponsor
White River Junction Veterans Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
White River Junction, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 4, 2024 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

NCT00854295
View directory record Official record
Conditions
Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities
Interventions
NexGen LPS-Flex Mobile Bearing Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2021
U.S. locations
3
States / cities
Tamarac, Florida • Auburn Hills, Michigan • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Jun 7, 2026, 9:09 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Theophylline for Depression Study

NCT04309877
View directory record Official record
Conditions
Depression
Interventions
Theophylline ER, PO placebo, Lipopolysaccharide (LPS), IV placebo
Drug · Other · Biological
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neuroimmune Response to Lipopolysaccharide

NCT04233593
View directory record Official record
Conditions
Healthy
Interventions
Lipopolysaccharide
Biological
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 18, 2022 · Synced Jun 7, 2026, 9:09 PM EDT
No Longer Available No phase listed Expanded access

Single-Patient Expanded Access Protocol - RNA-LP in a Patient With Recurrent Osteosarcoma

NCT07560709
View directory record Official record
Conditions
Recurrent Osteosarcoma
Interventions
pp65/tumor mRNA RNA-LP
Biological
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 17 Years · Male only
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial Comparing Isolite® vs. Cotton Roll Isolation in the Placement of Dental Sealants

NCT02668874
View directory record Official record
Conditions
Dental Caries on Pit and Fissure Surface
Interventions
Isolite System, Cotton Roll Technique
Device · Other
Lead sponsor
University of Iowa
Other
Eligibility
6 Years to 16 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Anaerobic Exercise and Mental Acuity

NCT05850221
View directory record Official record
Conditions
Depression, LPS, Mood
Interventions
weight training
Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

NCT06437405
View directory record Official record
Conditions
LPS, Mood Disorders, Cognitive Change
Interventions
Vinegar liquid, vinegar pill
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of TT301 on Cytokine Levels Post Endotoxin Challenge

NCT01357421
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
TT301, Placebo
Drug
Lead sponsor
OPKO Health, Inc.
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2013 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety and Feasibility of an Endotoxemia Model

NCT01329965
View directory record Official record
Conditions
Cardiovascular Disease, Inflammation
Interventions
LPS (reference endotoxin, E. coli O113:H10:K:neg, manufactured under GMP)
Drug
Lead sponsor
Penn State University
Other
Eligibility
20 Years to 35 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Jun 7, 2026, 9:09 PM EDT
Not listed Not applicable Interventional

Clinical Study of Abdominal Aortic Aneurysm Exclusion (TALENT Abdominal)

NCT00549432
View directory record Official record
Conditions
Abdominal Aortic Aneurysm
Interventions
TALENT Enhanced LPS Endoluminal Stent-Graft System
Device
Lead sponsor
Arizona Heart Institute
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 14, 2009 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 1 Interventional

A Multipeptide Vaccine Plus Toll-Like Receptor Agonists in Melanoma Patients

NCT01585350
View directory record Official record
Conditions
Melanoma
Interventions
MELITAC 12.1 + Montanide ISA-51 + lipopolysaccharide (LPS), MELITAC 12.1 + Montanide ISA-51 + polyICLC
Biological
Lead sponsor
Craig L Slingluff, Jr
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 11, 2016 · Synced Jun 7, 2026, 9:09 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis

NCT01968382
View directory record Official record
Conditions
Hepatitis, Alcoholic
Interventions
IMM 124-E (Hyperimmune Bovine Colostrum), Placebo (High protein milk powder)
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
3
States / cities
Indianapolis, Indiana • Rochester, Minnesota • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Jun 7, 2026, 9:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Nitric Oxide, LPS and the Pathogenesis of Asthma Phase 1

NCT00671229
View directory record Official record
Conditions
Healthy, Asthma
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 40 Years
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Jun 7, 2026, 9:09 PM EDT