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Showing 1–24 of 84 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Labour Pain Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

The Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes

NCT00787176
View directory record Official record
Conditions
Pregnancy, Labor Pain
Interventions
Group A Intravenous bolus of 1000 ml lactated ringers solution, Group B Intravenous bolus bolus 1000 ml lactated ringers solution oxytocin decrease to 1/2 current rate, Group C 125 mL/hr of lactated ringers, Group D 125 mL/hr lactated ringers oxytocin decreased to 1/2 current rate
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Epidural Catheter Thread Between Two Different Vendors

NCT03722446
View directory record Official record
Conditions
Labor Pain
Interventions
Arrow Catheter Kit., B.Braun Catheter Kit
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Sep 2, 2026, 10:14 PM EDT
Terminated Phase 2 Interventional Results available

Combined Spinal/Epidural (CSE) Saline Duration/Spread

NCT01062893
View directory record Official record
Conditions
Labor Pain
Interventions
Sterile normal saline 0 mls, 15 mls sterile normal saline
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
12 Years and older · Female only
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music and/or Video Games During Labor

NCT03024411
View directory record Official record
Conditions
Labor Pain
Interventions
iPod (Music/video games)
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older · Female only
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Sep 2, 2026, 10:14 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia

NCT05543694
View directory record Official record
Conditions
Labor Pain, Analgesia
Interventions
Bupivacaine Hydrochloride
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Phase 2 Interventional Results available

Combined Spinal-Epidural Temperature and Duration of Action

NCT02020304
View directory record Official record
Conditions
Pain
Interventions
combined spinal epidural
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 9, 2018 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CSE v. Epidural for Postpartum Depression

NCT03022526
View directory record Official record
Conditions
Depression, Postpartum, Labor Pain
Interventions
CSE, Epidural, Bupivacaine / fentaNYL
Procedure · Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Objective Pain Measurement Device

NCT03975660
View directory record Official record
Conditions
Pain, Analgesia, Labor Pain
Interventions
Pain Measurement Device
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2025 · Synced Sep 2, 2026, 10:14 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL

NCT06146842
View directory record Official record
Conditions
Labor Pain
Interventions
Bupivacaine Hydrochloride
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 2, 2026, 10:14 PM EDT
Terminated Phase 4 Interventional Results available

Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE

NCT01005459
View directory record Official record
Conditions
Labor Pain
Interventions
Tetracaine, Bupivacaine
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
12 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Sep 2, 2026, 10:14 PM EDT
Withdrawn Phase 4 Interventional

Epidural Fentanyl-bupivacaine Versus Clonidine-bupivacaine for Breakthrough Pain in Advanced Labor

NCT00691795
View directory record Official record
Conditions
Labor Pain
Interventions
Clonidine or fentanyl
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2012 · Synced Sep 2, 2026, 10:14 PM EDT
Terminated Phase 4 Interventional Results available

Drug Concentration and Volume on Adequate Labor Analgesia With PIEB

NCT03553576
View directory record Official record
Conditions
Pain, Anesthesia, Labor Pain
Interventions
Low volume bolus, High volume bolus
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Analgesia in Labor: The VRAIL Pilot Study

NCT02926469
View directory record Official record
Conditions
Labor Pain
Interventions
Virtual Reality
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 31, 2018 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of PIEB vs CEI for Labor Analgesia

NCT02949271
View directory record Official record
Conditions
Labor Pain
Interventions
Programmed Intermittent Epidural Bolus, Continuous Epidural Infusion, Ropivacaine, Fentanyl
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Sep 2, 2026, 10:14 PM EDT
Enrolling by invitation Not applicable Interventional

Exploring the Effect of Aromatherapy

NCT07155876
View directory record Official record
Conditions
Anxiety, Labor Pain, Nausea and Vomiting
Interventions
Aromatherapy plus standard of care, Standard of Care Only
Other
Lead sponsor
Baptist Health South Florida
Other
Eligibility
18 Years and older · Female only
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

DPE Technique in Labor Epidural for Morbidly Obese Women

NCT03074695
View directory record Official record
Conditions
Morbid Obesity, Labor Pain
Interventions
Dural puncture epidural (DPE), Standard Epidural (EPL), Dural puncture epidural (DPE), Standard Epidural (EPL)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Compared to Nitrous Oxide for Labor Analgesia

NCT04749043
View directory record Official record
Conditions
Labor Pain
Interventions
Oculus Quest 2 Virtual Reality Device, Nitrous oxide
Device · Drug
Lead sponsor
Brendan Carvalho
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Sep 2, 2026, 10:14 PM EDT
Not listed Phase 4 Interventional

Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia

NCT03623256
View directory record Official record
Conditions
Labor Pain, Obstetric Pain
Interventions
Spinal fentanyl, Spinal bupivacaine, Spinal Fentanyl and Bupivacaine, Epidural fentanyl /spinal bupivacaine
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older · Female only
Enrollment
558 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 2, 2026, 10:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality in Labor and Delivery for Reduction in Pain

NCT03437031
View directory record Official record
Conditions
Labor Pain, Virtual Reality, Alternative Medicine
Interventions
Virtual Reality device
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2021 · Synced Sep 2, 2026, 10:14 PM EDT
Terminated Not applicable Interventional Results available

The Optimal Dosage of Intrathecal Morphine for Peripartum Analgesia

NCT01146457
View directory record Official record
Conditions
Labor Pain
Interventions
Morphine, Saline
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 2, 2026, 10:14 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Effect of Epidural Analgesia During Labor on Force of Maternal Push

NCT04888858
View directory record Official record
Conditions
Labor Pain, Analgesia, Maternal; Procedure
Interventions
Epidural analgesia (0.125% bupivacaine/2mcg fentanyl solution)
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 24, 2023 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Prenatal Education on Perceptions of Epidural Acceptance

NCT01709591
View directory record Official record
Conditions
Labor Pain
Interventions
Prenatal education
Behavioral
Lead sponsor
Santa Clara Valley Health & Hospital System
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2020 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of the Use of Ultrasound for Epidural Catheter Placement and Comparison With Palpation Technique

NCT02271100
View directory record Official record
Conditions
Labor Pain
Interventions
ultrasound guidance, palpation guidance
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 2, 2026, 10:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Outcomes of Neuraxial Anesthetic Technique on the Trial of Labor After Cesarean (TOLAC)

NCT02105558
View directory record Official record
Conditions
Labor Pain, Complications; Cesarean Section, Pregnancy
Interventions
Epidural anesthesia, Combined spinal and epidural anesthesia
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Sep 2, 2026, 10:14 PM EDT