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ClinicalTrials.gov public records Last synced Jul 23, 2026, 5:17 PM EDT

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Showing 1–12 of 12 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Laryngeal Cancer, Laryngectomy
Interventions
SpeakFree HME Hands Free Valve, Digital Occlusion, Digital Depression HME
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Conditions
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Locally Advanced Laryngeal Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma
Interventions
Toripalimab, Carboplatin, Cisplatin, Paclitaxel, Radiation Therapy
Drug · Radiation
Lead sponsor
Matthew Spector
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Personalized Voice Restoration Device for Patients With Laryngectomy

NCT05479643
Conditions
Dysphonia, Aphonia
Interventions
Surface Electromyography
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 110 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2031
U.S. locations
1
States / cities
New York, New York
Conditions
Laryngectomy
Interventions
Provox® ActiValve®
Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Houston, Texas
Completed Not applicable Interventional

Laryngectomy Education

NCT02601638
Conditions
Total Laryngectomy
Interventions
Demographics and Health History Questionnaire, Pre-Class Laryngectomy Survey, Counseling session with speech pathologist, Total Laryngectomy Preoperative Education Class, Day of Hospital Discharge Laryngectomy Survey, Day of Discharge Practicum, Laryngectomy Education Study Exit Survey
Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Conditions
Larynx Cancer, Pharynx Cancer, Pharyngocutaneous Fistula
Interventions
Dehydrated human amnion/chorion membrane
Biological
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Suspended Not applicable Interventional

Laryngeal Allograft Transplantation

NCT03269396
Conditions
Larynx Stenosis, Larynx Disease, Laryngectomy, Larynx, Larynx Fracture
Interventions
Larynx Allograft Transplantation
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Results available

CPAP to Improve Swallow Function Post Total Laryngectomy

NCT03328702
Conditions
Oropharyngeal Dysphagia, Laryngectomy; Status
Interventions
Continuous Positive Airway Pressure
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Sacramento, California
Conditions
Squamous Cell Carcinoma, Laryngeal Cancer
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Laryngeal Cancer
Interventions
Hyperbaric Oxygen
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Head and Neck Cancer
Interventions
laser surgery, radiation therapy
Procedure · Radiation
Lead sponsor
SWOG Cancer Research Network
Network
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2007
U.S. locations
12
States / cities
Little Rock, Arkansas • Los Angeles, California • Sacramento, California + 9 more
Conditions
Speech Disorders, Speech Dysfunction, Laryngectomy; Status, Tracheoesophageal Prosthesis, Total Laryngectomy
Interventions
Not listed
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
La Jolla, California