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Showing 1–24 of 68 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Late-Life Depression Clear all
Recruiting Not applicable Interventional

Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

NCT06191484
View directory record Official record
Conditions
Suicide, Bereavement
Interventions
WELL Behavioral Probe
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 4 Interventional

Biomarkers for Outcomes In Late-life Depression (BOLD)

NCT01082237
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
62 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2013 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Games to Overcome Late Life Depression

NCT02229188
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Problem Solving Therapy, Evolution, Words
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Preventing Mid- and Later-Life Work Limitations

NCT01163890
View directory record Official record
Conditions
Depression
Interventions
Work and Health Initiative, Usual Medical or Behavioral Intervention
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
45 Years and older
Enrollment
431 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Sep 15, 2026, 5:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cortical/Subcortical Circuits in Late-Life Depression

NCT01327417
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Sep 15, 2026, 5:45 PM EDT
Recruiting Not applicable Interventional

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

NCT05877885
View directory record Official record
Conditions
Major Depressive Disorder, Apathy
Interventions
Targeted Cognitive Training Intervention, General Cognitive Training Intervention
Behavioral
Lead sponsor
AdventHealth
Other
Eligibility
60 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 4 Interventional

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

NCT00177567
View directory record Official record
Conditions
Bipolar Disorder
Interventions
lithium carbonate, Depakote-ER, risperidone, olanzapine, paroxetine, bupropion, lamotrigine, venlafaxine, tranylcypromine, mirtazapine
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2005 · Synced Sep 15, 2026, 5:45 PM EDT
Not yet recruiting Phase 2 Interventional

The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.

NCT07810738
View directory record Official record
Conditions
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
Interventions
Aripiprazole Augmentation, Bupropion Augmentation
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Not yet recruiting Not applicable Interventional

tDCS for Late-Life Depression

NCT07657234
View directory record Official record
Conditions
Late Life Depression (LLD)
Interventions
High-intensity (6 mA) transcranial direct current stimulation (tDCS)
Device
Lead sponsor
Andre Russowsky Brunoni
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Terminated Phase 4 Interventional Results available

L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults

NCT03761030
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia, Depression
Interventions
L-DOPA, Placebo Oral Tablet
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 15, 2026, 5:45 PM EDT
Terminated Phase 4 Interventional Results available

Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing

NCT04650217
View directory record Official record
Conditions
Depressive Disorder
Interventions
Carbidopa/levodopa, Placebo, Exercise training, Control
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Sep 15, 2026, 5:45 PM EDT
Recruiting Not applicable Interventional

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

NCT05925322
View directory record Official record
Conditions
Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions
"Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 2 Interventional

Depressed Mood Improvement Through Nicotine Dosing 3

NCT05746273
View directory record Official record
Conditions
Depressive Disorder
Interventions
Transdermal Nicotine Patch, Transdermal Placebo Patch
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional Results available

Electroconvulsive Therapy Amplitude Titration

NCT04621786
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
Device
Lead sponsor
University of New Mexico
Other
Eligibility
50 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 4 Interventional

Paroxetine in the Treatment of Chronic Primary Insomnia

NCT00178048
View directory record Official record
Conditions
Primary Insomnia, Depression
Interventions
paroxetine
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
55 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2005 · Synced Sep 15, 2026, 5:45 PM EDT
Recruiting Phase 3 Interventional

Lumateperone for Late-Life Depression

NCT07623135
View directory record Official record
Conditions
Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder
Interventions
Lumateperone, Placebo
Drug
Lead sponsor
Eric Lenze
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Tucson, Arizona • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 3 Interventional Results available

Ketamine for Treatment Resistant Late-Life Depression

NCT02556606
View directory record Official record
Conditions
Treatment Resistant Depressive Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression

NCT00339066
View directory record Official record
Conditions
Depression
Interventions
Sertraline
Drug
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
2
States / cities
St Louis, Missouri • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 4 Interventional Results available

Incomplete Response in Late Life Depression: Getting to Remission (IRL GREY)

NCT00892047
View directory record Official record
Conditions
Depression
Interventions
venlafaxine XR plus aripiprazole, venlafaxine plus placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
468 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
St Louis, Missouri • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Sep 15, 2026, 5:45 PM EDT
Terminated Not applicable Interventional Results available

Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression

NCT02943096
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
CocoaVia, Placebo
Dietary Supplement · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional Results available

Reward Function and Therapy for Late-Life Depression

NCT03688139
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Engage Therapy, Supportive Therapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dopaminergic Dysfunction in Late-Life Depression

NCT04469959
View directory record Official record
Conditions
Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Interventions
L-Dopa, Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Phase 4 Interventional

Treating Alcohol Use In Older Adults With Depression

NCT00018824
View directory record Official record
Conditions
Alcoholism, Depression
Interventions
NALTREXONE, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
55 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2009 · Synced Sep 15, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Primary Prevention of Major Depression in Later Life

NCT00326677
View directory record Official record
Conditions
Depression
Interventions
Problem Solving Therapy, Dietary Education
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
50 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 15, 2026, 5:45 PM EDT