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ClinicalTrials.gov public records Last synced Oct 23, 2026, 1:44 AM EDT

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Showing 265–288 of 1,036 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Leg Injuries Clear all
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single and Repeated Doses of Topical GSK1278863

NCT01831804
View directory record Official record
Conditions
Wound Healing
Interventions
GSK1278863, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 90 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
7
States / cities
Castro Valley, California • Washington D.C., District of Columbia • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 23, 2026, 1:44 AM EDT
Terminated Not applicable Interventional Results available

Safety Study of Femoral Neck Fracture System

NCT03721835
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
CONQUEST FN Femoral Neck Fracture System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Macon, Georgia • Winston-Salem, North Carolina • Fort Worth, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Phase 2 Interventional Results available

Study To Assess FRacTure Healing With SclerosTin Antibody - Hip

NCT01081678
View directory record Official record
Conditions
Fracture Healing
Interventions
Placebo, Romosozumab
Drug
Lead sponsor
Amgen
Industry
Eligibility
55 Years to 95 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
12
States / cities
Birmingham, Alabama • Pomona, California • Aurora, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 23, 2026, 1:44 AM EDT
Recruiting Not applicable Interventional

CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs

NCT07701590
View directory record Official record
Conditions
Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
Interventions
Microlyte®, IP 1: Membrane Wrap - Hydro
Device
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
7
States / cities
San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Phase 2 Interventional Results available

Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers

NCT00764361
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
doxycycline, placebo gel
Drug
Lead sponsor
NanoSHIFT LLC
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 7, 2017 · Synced Oct 23, 2026, 1:44 AM EDT
Enrolling by invitation Not applicable Interventional

Pain Management of ACL Reconstruction

NCT03365908
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Adductor Canal Nerve Block, Ropivacaine injection
Procedure · Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Not listed No phase listed Observational

Pelvic Fractures and Radiation Therapy for Cervical Cancer

NCT00800644
View directory record Official record
Conditions
Cervical Cancer, Endometrial Cancer, Vaginal Cancer
Interventions
CT or MRI + Blood Test
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Female only
Enrollment
239 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2020 · Synced Oct 23, 2026, 1:44 AM EDT
Not listed No phase listed Observational

Venous Leg Ulcer and Lymphedema Registry

NCT02813187
View directory record Official record
Conditions
Venous Stasis Ulcer, Quality of Patient Care
Interventions
cellular and tissue based therapy, debridement, advanced wound therapy, Nutritional screening
Biological · Procedure · Dietary Supplement
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 23, 2026, 1:44 AM EDT
Completed No phase listed Observational

Women's-Specific Footwear With Prosthetic Feet

NCT03673371
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Interventions
Questionnaire
Other
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 23, 2026, 1:44 AM EDT
Terminated Not applicable Interventional

Weight Change With Controlled Ankle Movement (CAM) Boot Use

NCT05692401
View directory record Official record
Conditions
Ankle Injuries, Foot Injuries and Disorders, Body Weight Changes
Interventions
Nutrition and Exercise Instruction
Behavioral
Lead sponsor
Nell Blake, DPM
Other
Eligibility
18 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 23, 2026, 1:44 AM EDT
Completed No phase listed Observational

Plating of Distal Femur Fractures by Far Cortical Locking Using MotionLoc Screws

NCT01667887
View directory record Official record
Conditions
Fracture of Distal Femur
Interventions
Not listed
Lead sponsor
Legacy Biomechanics Laboratory
Other
Eligibility
17 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 29, 2013 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional

C Scope Visualization System Prospective Study

NCT05153863
View directory record Official record
Conditions
Knee Injuries and Disorders, Shoulder Disease, Shoulder Injuries
Interventions
C Scope Visualization System
Device
Lead sponsor
CIT Ortho
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Henderson, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 23, 2026, 1:44 AM EDT
Not listed Not applicable Interventional

The IM ABLE Study: A Study of Warriors & Veterans Following Neuromusculoskeletal Injury of the Lower Limb

NCT03107728
View directory record Official record
Conditions
Limb Salvage, Braces, Lower Extremity
Interventions
Advanced orthotic brace, Conventional orthotic brace
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 23, 2026, 1:44 AM EDT
Active, not recruiting Not applicable Interventional

Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity

NCT07792616
View directory record Official record
Conditions
Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Spinal Cord Injuries, Spasticity, Spasm, Muscle Spasticity, Muscle Hypertonia, Muscle Spasm
Interventions
Transcutaneous spinal stimulation at 30 Hz, Transcutaneous spinal stimulation at 75 Hz, Tizanidine, Baclofen, Placebo
Other · Drug
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional Results available

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

NCT02584452
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Interventions
Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine, adductor canal nerve block, ropivacaine and dexamethasone, Propofol, Fentanyl
Drug · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional

Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification

NCT06569238
View directory record Official record
Conditions
Diabetic Foot Ulcer, Diabetes Mellitus, Wound
Interventions
Conventional bacterial culture, Rapid diagnostic group using mNGS technology
Diagnostic Test · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neurophysiology of Ankle Instability

NCT06576687
View directory record Official record
Conditions
Ankle Injuries
Interventions
Physical Rehabilitation
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Community Ambulation After Hip Fracture

NCT01783704
View directory record Official record
Conditions
Hip Fracture
Interventions
Nutrition, PUSH, PULSE
Dietary Supplement · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
4
States / cities
Farmington, Connecticut • Baltimore, Maryland • Lebanon, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Outcomes Following Patellar Dislocation in Young Athletes

NCT03040232
View directory record Official record
Conditions
Patella Dislocation Recurrent, Patellar Dislocation
Interventions
biomechanical assessment
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Years to 25 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 23, 2026, 1:44 AM EDT
Recruiting Not applicable Interventional

CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations

NCT07046767
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer, Wound; Foot
Interventions
IP1: BioLab Membrane Wrap Lite IP2: BioLab Tri-Membrane Wrap, IP2: BioLab Tri-Membrane Wrap
Other
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
7
States / cities
Oxnard, California • Coral Gables, Florida • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 23, 2026, 1:44 AM EDT
Completed Not applicable Interventional

A Prospective, Multi Centre, Interventional, Non-comparator, Open Label Study to Demonstrate the Efficacy, Safety, and Performance of ConvaFoam™ Dressings in the Management of Indicated Chronic Wound Types.

NCT05632250
View directory record Official record
Conditions
Chronic Ulcer of Leg or Foot, Pressure Injury
Interventions
ConvaFoam
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
5
States / cities
Hagerstown, Maryland • Mineola, New York • Raleigh, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 23, 2026, 1:44 AM EDT
Completed No phase listed Observational

The Impact of Tibial Tubercle-trochlear Groove Distance and Patellar Height on the Outcome of Isolated Medial Patellofemoral Ligament Reconstruction

NCT03076008
View directory record Official record
Conditions
Patellar Dislocation
Interventions
Observational
Other
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 90 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Leg Heating in Pregnant Women With Obesity

NCT06932250
View directory record Official record
Conditions
High-risk Pregnancy
Interventions
Leg heating
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 23, 2026, 1:44 AM EDT
Recruiting Phase 1Phase 2 Interventional

Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers

NCT07396376
View directory record Official record
Conditions
Diabetic Foot Ulcer, Wagner Grade 1 - 2, Chronic Wound, Open Wound
Interventions
ELU42 Topical Spray
Drug
Lead sponsor
Eluciderm Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
O'Fallon, Illinois • Springfield, Illinois • Oradell, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 23, 2026, 1:44 AM EDT