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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Limb Amputation Clear all
Terminated No phase listed Observational

Patient Reported Outcomes Following Targeted Muscle Reinnervation

NCT04658368
View directory record Official record
Conditions
Amputation
Interventions
Primary TMR, Secondary TMR
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 17, 2026, 7:12 AM EDT
Recruiting Not applicable Interventional

Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses

NCT06539936
View directory record Official record
Conditions
Amputation, Upper Limb
Interventions
Glide, Direct Control
Device
Lead sponsor
Infinite Biomedical Technologies
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Redondo Beach, California
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 17, 2026, 7:12 AM EDT
Not listed No phase listed Observational

Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility

NCT05265403
View directory record Official record
Conditions
Amputation of Lower Limb Below Knee
Interventions
Commercially-available energy storage and return prosthetic foot, MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet
Drug · Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional

Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee

NCT02773056
View directory record Official record
Conditions
Amputation
Interventions
Ischial Ramus Containment (IRC), Dynamic Socket Ischial Ramus Containment (IRC), Sub-Ischial Interface (Sub-I)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 44 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Phase 2 Interventional

Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain

NCT00383682
View directory record Official record
Conditions
Amputation, Chronic Pain
Interventions
morphine and mexiletine
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2003
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 2, 2006 · Synced Sep 17, 2026, 7:12 AM EDT
Recruiting No phase listed Observational

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

NCT06908538
View directory record Official record
Conditions
Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions
cryoablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
6
States / cities
Pittsfield, Massachusetts • Manchester, New Hampshire • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Results available

C-RFA of Residual Limb Neuroma

NCT04538417
View directory record Official record
Conditions
Phantom Limb Pain, Neuroma Amputation
Interventions
Cooled Radiofrequency Ablation
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit

NCT00117793
View directory record Official record
Conditions
Amputation, Diabetes, Leg Injuries, Traumatic Amputations
Interventions
Total Surface Bearing Suction Socket, Vacuum assisted socket system
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 14, 2014 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions

NCT00566657
View directory record Official record
Conditions
Peripheral Vascular Diseases
Interventions
riferminogene pecaplasmid, Placebo (for riferminogene pecaplasmid)
Biological
Lead sponsor
Sanofi
Industry
Eligibility
50 Years and older
Enrollment
525 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2016 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Functional Outcomes of Voice Recognition Prosthesis

NCT04595071
View directory record Official record
Conditions
Prosthesis, Amputation, Prosthesis User
Interventions
Voice Activated Prosthetic Interface (VAPI) Controller
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Results available

Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program

NCT00942890
View directory record Official record
Conditions
Traumatic Amputation
Interventions
NMES (EMPI 300PV stimulator) plus standard of care, TMARP standard of care
Device · Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
San Diego, California • Bethesda, Maryland • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Sep 17, 2026, 7:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessment of Socket Shapes Made by Central Fabrication Facilities

NCT01245504
View directory record Official record
Conditions
People With Lower Limb Amputation That Are Ambulatory
Interventions
Assessed for socket fit
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 24, 2014 · Synced Sep 17, 2026, 7:12 AM EDT
Recruiting Phase 2 Interventional

Human Upper Extremity Allotransplantation

NCT01459107
View directory record Official record
Conditions
Amputation, Traumatic, Wounds and Injuries, Hand Injuries
Interventions
Deceased donor hand transplantation, Bone marrow cell-based therapy & single-drug immunosuppression.
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 69 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2036
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 17, 2026, 7:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Falls in Older Persons With Limb Loss

NCT03670004
View directory record Official record
Conditions
Amputation, Elderly
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2022 · Synced Sep 17, 2026, 7:12 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Reiki for the Management of Neuropathic Pain

NCT02328703
View directory record Official record
Conditions
Neuropathic Pain, Amputation, Traumatic
Interventions
Reiki Therapy
Other
Lead sponsor
Fort Belvoir Community Hospital
Federal
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 17, 2026, 7:12 AM EDT
Completed No phase listed Observational

Regenerative Peripheral Nerve Interfaces for the Treatment of Painful Neuromas in Major Limb Amputees

NCT07285486
View directory record Official record
Conditions
Amputation Neuroma
Interventions
Amputation with Regenerative Peripheral Nerve Interfaces (RPNI), Amputation Without RPNI
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prosthetic Components and Stability in Amputee Gait

NCT00167778
View directory record Official record
Conditions
Diabetes Mellitus, Leg Injuries, Traumatic Amputation
Interventions
Transverse plane rotation adaptor pylon, Rigid pylon
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 14, 2014 · Synced Sep 17, 2026, 7:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

KinetiGait- Analysis of Depth Camera to Assist Gait Analysis for Unilateral Transtibial/Transfemoral Amputees

NCT04431817
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
KinetiGait
Device
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 17, 2026, 7:12 AM EDT
Withdrawn Not applicable Interventional

Evaluation of a Multi-electrode Prosthesis Control System for Real-world Tasks Performance in Individuals With Upper Limb Transradial Amputation

NCT07071584
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow
Interventions
Cutaneous Prosthesis Control System
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 17, 2026, 7:12 AM EDT
Completed Phase 1Phase 2 Interventional

Improving Outcomes Following Limb Loss: PALS Plus

NCT00447655
View directory record Official record
Conditions
Amputation
Interventions
Self-management and peer support
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Sep 17, 2026, 7:12 AM EDT
Active, not recruiting Not applicable Interventional

Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users

NCT03930199
View directory record Official record
Conditions
Amputation
Interventions
Needs-based intervention (physical, psychological, or both)
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 89 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
3
States / cities
Chicago, Illinois • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 17, 2026, 7:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Enhancing Upper Limb Prostheses With Radio Frequency Identification

NCT01967004
View directory record Official record
Conditions
Below Elbow Amputation
Interventions
Morph
Device
Lead sponsor
Infinite Biomedical Technologies
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Sep 17, 2026, 7:12 AM EDT
Not yet recruiting Not applicable Interventional

Neuromusculoskeletal Interface for Bionic Arms

NCT07032753
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation, Surgical, Upper Limb Amputation Above Elbow (Injury)
Interventions
eOPRA, OPRA, eOPRA with sensory feedback, eOPRA without sensory feedback
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 23, 2025 · Synced Sep 17, 2026, 7:12 AM EDT