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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Limb Fracture Clear all
Completed No phase listed Observational

Optional Follow-up Visits for Common, Low-risk Arm Fractures

NCT01583556
View directory record Official record
Conditions
Mallet Fracture, Metacarpal Fracture, Metacarpal Neck Fracture, Distal Radius Fracture, Radial Head Fracture
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 25, 2026, 1:26 AM EDT
Completed No phase listed Observational

Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion

NCT05143476
View directory record Official record
Conditions
Humerus Fractures
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Splinting Versus Not Splinting of the Distal Lower Extremity After Intramedullary Nailing for Tibial Fractures

NCT00888550
View directory record Official record
Conditions
Tibia Fracture
Interventions
Post-Op Splinting, No Splinting
Procedure
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2010 · Synced Sep 25, 2026, 1:26 AM EDT
Terminated Not applicable Interventional

Humeral Compression/Distraction Device

NCT02861495
View directory record Official record
Conditions
Humeral Fractures
Interventions
Humeral Compression/Distraction (CD) Nail
Device
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 25, 2026, 1:26 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures

NCT03466242
View directory record Official record
Conditions
Conscious Sedation, Distal Radius Fracture
Interventions
Dexmedetomidine, Ketamine
Drug
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
2 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional

VR-Based Physical Therapy Pilot Study

NCT03779425
View directory record Official record
Conditions
Extremity Fracture Lower
Interventions
Virtual Reality Physical Therapy
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 25, 2026, 1:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

NCT05845021
View directory record Official record
Conditions
Osteoporosis, Arthroplasty Complications, Fragility Fracture
Interventions
Surgeon-Initiated Bone Health Referral Pathway
Combination Product
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional Results available

Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting

NCT05843864
View directory record Official record
Conditions
Metatarsal Stress Fracture, Stress Fracture of Tibia
Interventions
Photobiomodulation Therapy with Standard Physical Therapy, Sham Photobiomodulation Therapy with Standard Physical Therapy
Device · Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
17 Years to 64 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Terminated Not applicable Interventional Results available

Foot and Ankle Range of Motion (Stretching) Apparatus

NCT00527748
View directory record Official record
Conditions
Plantar Fasciitis, Flatfoot, Calcaneus Fractures
Interventions
Non-Measuring Ankle Exerciser
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Limb Pre-Conditioning Reduce Pain After Hip Arthroscopy

NCT04925791
View directory record Official record
Conditions
Hip Injuries, Hip Dislocation, Hip Fractures
Interventions
standardized pre-conditioning treatment, Partial occlusion
Diagnostic Test
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Use of a Self-Directed Exercise Program (SDEP) Following Selected Lower Extremity Fractures

NCT04612478
View directory record Official record
Conditions
Musculoskeletal Injury
Interventions
Self-Directed Exercise Program, Clinic-Based Physical
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Phase 3 Interventional

Tobramycin Injection to Prevent Infection in Open Fractures

NCT04964947
View directory record Official record
Conditions
Wound Infection, Fractures, Open, Surgical Site Infection
Interventions
Tobramycin Injection
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Lexington, Kentucky • Boston, Massachusetts • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Not yet recruiting Not applicable Interventional

Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries

NCT07828613
View directory record Official record
Conditions
Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
Interventions
Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
31
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 24 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Active, not recruiting Phase 4 Interventional

PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)

NCT05763602
View directory record Official record
Conditions
Surgical Site Infection
Interventions
povidone-iodine topical ointment
Drug
Lead sponsor
Loreen Herwaldt
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
6
States / cities
Atlanta, Georgia • Indianapolis, Indiana • Iowa City, Iowa + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Terminated Not applicable Interventional Results available

The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures

NCT02051933
View directory record Official record
Conditions
Equinus Contracture
Interventions
Botulinum toxin type A, sodium chloride
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Phase 4 Interventional Results available

Single Shot Versus OnQ Pump in Extremity Fractures

NCT02280291
View directory record Official record
Conditions
Pain, Fracture
Interventions
Ankle SSB, Ankle OnQ, DR SSB, DR OnQ
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 25, 2026, 1:26 AM EDT
Recruiting Not applicable Interventional

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608
View directory record Official record
Conditions
Osteoporosis, Lower Limb Fracture
Interventions
OPTIONS, Enhanced usual care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
1,344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 25, 2026, 1:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Insole Sensor to Determine Optimal Limb Loading

NCT02170493
View directory record Official record
Conditions
Lower Extremity Fractures
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Phase 2 Interventional Results available

IN Sub-Dissociative Ketamine vs IN Fentanyl

NCT02521415
View directory record Official record
Conditions
Bone Fracture
Interventions
ketamine, fentanyl, ibuprofen or acetaminophen
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
4 Years to 17 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Sep 25, 2026, 1:26 AM EDT
Terminated Not applicable Interventional Results available

VeraFlo With Prontosan® and Wound and Fracture Healing.

NCT02621073
View directory record Official record
Conditions
Infection
Interventions
VeraFlo with Prontosan, V.A.C Ulta System
Drug · Device
Lead sponsor
Brett Crist
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 19, 2019 · Synced Sep 25, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Upper Extremity Post-op Splints: Do They Improve Post-operative Pain?

NCT03891966
View directory record Official record
Conditions
Extremity Injury
Interventions
Rigid Splint, Soft Dressing
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Sep 25, 2026, 1:26 AM EDT
Completed No phase listed Observational

SFDI in High Energy Lower Extremity Fracture

NCT05635617
View directory record Official record
Conditions
Trauma Injury
Interventions
Lower Extremity Surgery
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 25, 2026, 1:26 AM EDT
Recruiting Not applicable Interventional

Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery

NCT05445960
View directory record Official record
Conditions
Ankle Fractures, Ankle Fracture - Lateral Malleolus, Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar, Ankle Fracture - Medial Malleolus, Maisonneuve's Fracture, Syndesmotic Injuries, Fibula Fracture
Interventions
Tourniquet
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 25, 2026, 1:26 AM EDT
Not yet recruiting Phase 3 Interventional

Morphine or Ketamine for Analgesia

NCT06835504
View directory record Official record
Conditions
Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
Interventions
Ketamine hydrochloride, Morphine sulphate
Drug
Lead sponsor
Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
1,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Los Angeles, California • Sacramento, California • Wilmington, Delaware + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 25, 2026, 1:26 AM EDT