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Showing 25–40 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Limb Weakness Clear all
Recruiting Not applicable Interventional

Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke

NCT03980457
View directory record Official record
Conditions
Stroke, Weakness of Extremities as Sequela of Stroke
Interventions
Indego Exoskeleton, Standard Rehabilitation
Device · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jun 26, 2026, 11:27 PM EDT
Terminated Not applicable Interventional Results available

Galvanic Vestibular Stimulation and Motor Training in Traumatic Brain Injury Survivors

NCT01749800
View directory record Official record
Conditions
TBI, Attention Deficits, Motor Impairments
Interventions
GVS, Sham GVS, Armeo Spring
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Jun 26, 2026, 11:27 PM EDT
Recruiting No phase listed Observational

Molecular Analysis of Patients With Neuromuscular Disease

NCT00390104
View directory record Official record
Conditions
Neuromuscular; Disorder, Hereditary, Duchenne/Becker Muscular Dystrophy, Limb-girdle Muscular Dystrophy
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Week to 100 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Jun 26, 2026, 11:27 PM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate Lower Extremity Sleeve and Pump Device to Treat Hemiparesis

NCT05535257
View directory record Official record
Conditions
Upper Extremity Weakness, Stroke
Interventions
Sequential Compression Device
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Saint Johns, Florida
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jun 26, 2026, 11:27 PM EDT
Completed Not applicable Interventional

Assessment and Referral Versus Exercise in Primary Prevention of Falls: PA Healthy Steps Program

NCT01552551
View directory record Official record
Conditions
Lower Extremity Weakness Distal, Distorted; Balance
Interventions
Assessment and education, Healthy Steps with Falls Case Management, Healthy Steps in Motion
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 100 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 29, 2015 · Synced Jun 26, 2026, 11:27 PM EDT
Not listed Not applicable Interventional

mGain - sEMG-based Gamified Therapy for Improved Upper Limb Rehabilitation

NCT06023316
View directory record Official record
Conditions
Upper Limb Weakness Due to Central Neurologic Injury, Upper Limb Weakness Due to Peripheral Neurologic Injury, Upper Limb Weakness Due to Nerve Reconstruction, Upper Limb Weakness Due to Tendon Transfer Surgery, Stroke, Upper Limb Amputation
Interventions
mGain system
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jun 26, 2026, 11:27 PM EDT
Completed Not applicable Interventional

Video Game-based Therapy for Arm Weakness In Progressive Multiple Sclerosis

NCT03094364
View directory record Official record
Conditions
Primary Progressive Multiple Sclerosis, Hemiparesis
Interventions
Gaming CI Therapy
Behavioral
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Jun 26, 2026, 11:27 PM EDT
Completed No phase listed Observational

Effect of a Home-based Electrical Stimulation on Quadriceps Function After Knee Surgery

NCT02058862
View directory record Official record
Conditions
Post-operative Quadriceps Weakness, Post-operative Quadriceps Inhibition, Adherence to Post-operative Treatment, Post-operative Lower Extremity Function
Interventions
Not listed
Lead sponsor
University of Kentucky
Other
Eligibility
12 Years to 60 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 8, 2018 · Synced Jun 26, 2026, 11:27 PM EDT
Terminated Not applicable Interventional Results available

Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients

NCT02332187
View directory record Official record
Conditions
Weakness
Interventions
Active electrical stimulation using an All Stim stimulator, Sham electrical stimulation using an All Stim stimulator
Device
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jun 26, 2026, 11:27 PM EDT
Terminated Phase 4 Interventional Results available

Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?

NCT03382925
View directory record Official record
Conditions
Cervical Radiculopathy
Interventions
cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine, Triamcinolone Acetonide, Normal saline
Procedure · Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 24, 2022 · Synced Jun 26, 2026, 11:27 PM EDT
Completed No phase listed Observational Results available

Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders

NCT03398070
View directory record Official record
Conditions
Conversion Disorder
Interventions
Standard of Care
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Jun 26, 2026, 11:27 PM EDT
Recruiting Not applicable Interventional

At Home Wearable Sensors and Smartphone for Stroke Survivors With Upper Limb Motor Challenges.

NCT06787729
View directory record Official record
Conditions
Stroke
Interventions
mHealth
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jun 26, 2026, 11:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults

NCT04437251
View directory record Official record
Conditions
Vascular Accident, Brain, CVA (Cerebrovascular Accident), Gait, Hemiplegic, Spastic Lower Extremity Weakness
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
Texas Woman's University
Other
Eligibility
21 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Jun 26, 2026, 11:27 PM EDT
Completed Not applicable Interventional

BFRT for Severe Lower Extremity Muscle Atrophy

NCT04357184
View directory record Official record
Conditions
Severe Muscle Atrophy, Muscle Weakness
Interventions
Blood flow restriction training
Other
Lead sponsor
Cincinnati Sportsmedicine Research and Education Foundation
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Jun 26, 2026, 11:27 PM EDT
Completed Not applicable Interventional Results available

EMG Training for Altering Activation Patterns After Stroke

NCT03619772
View directory record Official record
Conditions
Stroke, Weakness, Muscle, Coordination Lack
Interventions
Bilateral, Unilateral
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jun 26, 2026, 11:27 PM EDT
Recruiting Not applicable Interventional

Biomarkers of Reaction To HIIT Exercise

NCT06059872
View directory record Official record
Conditions
Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty
Interventions
High Intensity Interval Training (HIIT)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jun 26, 2026, 11:27 PM EDT