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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:52 PM EDT

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Showing 289–312 of 446 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Local Anesthesia Clear all
Completed Phase 4 Interventional Results available

Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures

NCT03305666
View directory record Official record
Conditions
Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified, Pain; Catheter (Other), Nerve Pain, Local Infiltration, Anesthesia, Local, Intercostal Rib, Opioid Dependence, Chest Injury Trauma, Pneumonia
Interventions
Liposomal bupivacaine injection, Bupivacaine indwelling catheter
Drug
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 20, 2026, 3:52 PM EDT
Completed No phase listed Observational Results available

Total Hip Arthroplasty Outcomes With Regional and Multimodal Analgesia

NCT02186795
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip, Arthritis
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2019 · Synced Oct 20, 2026, 3:52 PM EDT
Recruiting Phase 4 Interventional

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

NCT04849455
View directory record Official record
Conditions
Hepatic Resection, Acute Pain, Anesthesia, Anesthesia, Local
Interventions
0.2% ropivacaine local anesthetic continuous erector spinae plane block, 0.2% ropivacaine local anesthetic superficially taped continuous erector spinae plane block, Spinal Morphine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 4 Interventional

LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery

NCT00847093
View directory record Official record
Conditions
Post-Operative Pain
Interventions
LMX4, LMX4 Placebo
Drug
Lead sponsor
Ferndale Laboratories, Inc.
Industry
Eligibility
3 Months to 3 Years · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2011 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Not applicable Interventional

Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement

NCT01409278
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ropivacaine infiltration and saline infusion., Ropivacaine infiltration and infusion., Normal Saline
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution

NCT04513652
View directory record Official record
Conditions
Anesthesia, Local
Interventions
AG-920, Placebo
Drug
Lead sponsor
American Genomics, LLC
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Not applicable Interventional Results available

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

NCT02849678
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine, Lidocaine
Drug
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years to 80 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Not applicable Interventional

Ultrasound Guided Sciatic Nerve Block

NCT02688439
View directory record Official record
Conditions
Sciatic Nerve
Interventions
Sciatic Nerve block, Leg raised 30°, Distal tourniquet placed on the lower part of the leg, Leg in a neutral position
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Oct 20, 2026, 3:52 PM EDT
Withdrawn Phase 4 Interventional

Articaine vs Lidocaine for Pediatric Dental Procedures

NCT03318952
View directory record Official record
Conditions
Anesthesia, Dental, Pain, Postoperative
Interventions
lidocaine, articaine
Drug
Lead sponsor
Boston University
Other
Eligibility
4 Years to 14 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 20, 2026, 3:52 PM EDT
Not yet recruiting Not applicable Interventional

Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT

NCT06964347
View directory record Official record
Conditions
Amputation
Interventions
Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2%
Device · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Stanford, California • Jacksonville, Florida • Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 9, 2025 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 3 Interventional

Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy

NCT00600158
View directory record Official record
Conditions
Postoperative Ileus
Interventions
bupivacaine with hydromorphone, lidocaine
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 24, 2008 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar

NCT01567839
View directory record Official record
Conditions
Anesthetic Effectiveness
Interventions
Mandibular buccal Infiltration injection
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 1, 2014 · Synced Oct 20, 2026, 3:52 PM EDT
Completed No phase listed Observational Results available

Defining Normal Postoperative Magnetic Resonance Imaging After Total Knee Arthroplasty

NCT04821245
View directory record Official record
Conditions
Local Anesthetic Complication, Local Anesthetic Drug Adverse Reaction
Interventions
Not listed
Lead sponsor
Benaroya Research Institute
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine

NCT06293807
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Xylocaine 2 % with 1:100,000 epinephrine, Bupivicaine 0.5% with 1:200,000 epinephrine, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 20, 2026, 3:52 PM EDT
Recruiting Phase 3 Interventional

Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution

NCT04792034
View directory record Official record
Conditions
ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
Interventions
Cocaine Hydrochloride Nasal Solution
Drug
Lead sponsor
LXO Ireland
Industry
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
6
States / cities
Columbia, South Carolina • Lugoff, South Carolina • Newberry, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Early Phase 1 Interventional

Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures

NCT06299137
View directory record Official record
Conditions
Rib Fractures, Pain Acute, Regional Anesthesia, Opioid Use
Interventions
Serratus Anterior Plane Block, Ropivacaine injection
Procedure · Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy

NCT04996251
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Injection
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Bacteriostatic Saline to Buffered Lidocaine for Ultrasound Guided Hip Joint Injection Local Anesthesia

NCT02209272
View directory record Official record
Conditions
Hip Pain
Interventions
bacteriostatic saline, buffered lidocaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.

NCT01862614
View directory record Official record
Conditions
Anesthetic Effectiveness
Interventions
Articaine Hydrochloride + Epinephrine, Buffered Articaine Hydrochloride + Epinephrine
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Oct 20, 2026, 3:52 PM EDT
Withdrawn Phase 4 Interventional

Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies

NCT04077398
View directory record Official record
Conditions
Analgesia, Postoperative Pain, Block
Interventions
Ropivacaine 0.5% Injectable Solution
Drug
Lead sponsor
Bruce Ben-David
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bilateral Paravertebral Blockade (T7-10) vs. Incisional Local Anesthetic Administration for Pediatric Patients

NCT01380834
View directory record Official record
Conditions
Pain, Postoperative
Interventions
control group, treatment group
Drug
Lead sponsor
Mihaela Visoiu
Other
Eligibility
8 Years to 17 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2017 · Synced Oct 20, 2026, 3:52 PM EDT
Terminated Phase 2Phase 3 Interventional

A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery

NCT00586976
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Ropivacaine, Normal saline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 20, 2026, 3:52 PM EDT
Completed Not applicable Interventional Results available

Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty

NCT01333943
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Study Group: Experimental, Control Group
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 90 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 20, 2026, 3:52 PM EDT
Terminated No phase listed Observational

Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee Arthroplasty

NCT03294174
View directory record Official record
Conditions
Opioid Tolerance, Opioid Naive, Opioid Exposure
Interventions
Ropivacaine injection
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 9, 2018 · Synced Oct 20, 2026, 3:52 PM EDT