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ClinicalTrials.gov public records Last synced Oct 19, 2026, 11:01 PM EDT

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Showing 145–168 of 446 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Local Anesthesia Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Pain Perception During Chorionic Villus Sampling

NCT03140293
View directory record Official record
Conditions
Chorionic Villi Sampling
Interventions
Lidocaine injection, Gebauer Ethyl Chloride Spray
Drug
Lead sponsor
Angela Bianco
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Oct 19, 2026, 11:01 PM EDT
Withdrawn Phase 3 Interventional

Regional Anesthesia and Endometrial Cancer Recurrence

NCT00531349
View directory record Official record
Conditions
Cancer
Interventions
propofol general anesthesia, Sevoflurane
Procedure · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2016 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 3 Interventional Results available

Regional Anesthesia and Breast Cancer Recurrence

NCT00418457
View directory record Official record
Conditions
Breast Neoplasms
Interventions
General anesthesia and opioids, Regional analgesia and propofol
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
2,108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 4 Interventional Results available

Block and Periarticular Injection Study

NCT06410612
View directory record Official record
Conditions
Pain, Postoperative
Interventions
regional anesthesia and PAI, PAI
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Creve Coeur, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 2 Interventional Results available

Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures

NCT01516684
View directory record Official record
Conditions
Malignant Neoplasm
Interventions
placebo administration, EMLA, propofol, fentanyl citrate
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Up to 22 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Not applicable Interventional Results available

UroLift System TOlerability and ReCovery When Administering Local Anesthesia

NCT01876706
View directory record Official record
Conditions
Benign Prostatic Hyperplasia
Interventions
UroLift® System
Device
Lead sponsor
NeoTract, Inc.
Industry
Eligibility
50 Years and older · Male only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
7
States / cities
San Diego, California • Daytona Beach, Florida • St. Petersburg, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study

NCT03936387
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Ropivacaine
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 21 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Split Face Study of the Duration of Local Anesthetics

NCT05767749
View directory record Official record
Conditions
Anesthetics, Local
Interventions
lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 19, 2026, 11:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer

NCT05698576
View directory record Official record
Conditions
Prostate Cancer, Adverse Effects Surgery, MRI, Ultrasound, Sexual Function Disturbances, Urinary Incontinence, Urinary Function Disorders, Prostate Biopsy, Ablation
Interventions
TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
Device
Lead sponsor
Urological Research Network, LLC
Other
Eligibility
50 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2033
U.S. locations
1
States / cities
Hialeah, Florida
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 19, 2026, 11:01 PM EDT
Terminated Phase 4 Interventional Results available

Exparel vs. Standard Bupivicaine for Abdominoplasty

NCT01853176
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Liposomal Injection Bupivacaine (Exparel), Standard bupivicaine
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2014 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid

NCT01350024
View directory record Official record
Conditions
Blepharoptosis
Interventions
Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine
Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients

NCT01474382
View directory record Official record
Conditions
Dental Anesthesia, Anesthesia, Local, Anesthesia, Reversal
Interventions
OraVerse, Sham injection
Drug · Other
Lead sponsor
Novocol Pharmaceutical of Canada, Inc.
Industry
Eligibility
2 Years to 5 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
7
States / cities
San Francisco, California • Indianapolis, Indiana • Columbus, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 29, 2014 · Synced Oct 19, 2026, 11:01 PM EDT
Not yet recruiting Not applicable Interventional

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome

NCT06953661
View directory record Official record
Conditions
Postural Tachycardia Syndrome
Interventions
Stellate ganglion block, Sham injection of saline, Ropivacaine, Normal saline
Procedure · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 2 Interventional Results available

IINB vs. QLB for Elective Open Inguinal Herniorrhaphy

NCT03007966
View directory record Official record
Conditions
Nerve Block, Herniorrhaphy, Regional Anesthesia
Interventions
Ilioinguinal / Iliohypogastric Block, Quadratus Lumborum Block, Bupivacaine 0.25%, Epinephrine 1:200k, Clonidine 1.66mcg/cc
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 4 Interventional Results available

Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures

NCT05294640
View directory record Official record
Conditions
Eyelid Tumor, Eyelid Bump, Eyelid Deformity, Eyelid Abscess, Eyelid Boil, Eyelid Papilloma, Anesthesia, Local, Ophthalmology
Interventions
0.9% Bacteriostatic Local Anesthetic Injection, 1% Lidocaine with 1:100,000 epinephrine Local Anesthetic Injection, Eyelid Lesion Removal
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 110 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Not applicable Interventional

The Specificity of Cervical Facet Medial Branch Blocks

NCT00613340
View directory record Official record
Conditions
Neck Pain, Cervical Facet Arthropathy
Interventions
Cervical medial branch blocks
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 7, 2009 · Synced Oct 19, 2026, 11:01 PM EDT
Terminated No phase listed Observational

PACMAN Ultrasound Recording Data Collection

NCT03368976
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Not listed
Lead sponsor
Avanos Medical
Other
Eligibility
18 Years and older
Enrollment
767 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
8
States / cities
Washington D.C., District of Columbia • Gulf Breeze, Florida • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 19, 2026, 11:01 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Use of Lumbar Erector Spinae Plane Block for Hip Arthroplasty at the L4 Interspace

NCT03801863
View directory record Official record
Conditions
Hip Arthropathy, Regional Anesthesia
Interventions
Ultrasound-guided Erector Spinae Plane Block with Ropivacaine 0.375%, Ropivacaine
Procedure · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2023 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)

NCT02223364
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 19, 2026, 11:01 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparison of an Office-based Limited Facelift and Hospital-based Full Facelift

NCT05419609
View directory record Official record
Conditions
Skin Aging, Facial Asymmetry, Aging Problems
Interventions
Limited facelift, Full facelift, FACE-Q | Aesthetics - Satisfaction With Lower Face and Jawline, FACE-Q | Aesthetics - Recovery Early Symptoms, FACE-Q | Aesthetics - Satisfaction with Outcome, FACE-Q | Aesthetics - Adverse Effects: Cheeks, Lower Face, Neck
Procedure · Other
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
40 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Not applicable Interventional Results available

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

NCT02849678
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine, Lidocaine
Drug
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years to 80 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Oct 19, 2026, 11:01 PM EDT
Completed No phase listed Observational

Regional Anesthesia Versus General Anesthesia on Circulating Tumor Cells (CTC)

NCT01716065
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 30, 2014 · Synced Oct 19, 2026, 11:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks

NCT03442036
View directory record Official record
Conditions
Regional Anesthesia, Sciatic Nerve Block
Interventions
Suture-Method Technique, Through-the-Needle Technique
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Oct 19, 2026, 11:01 PM EDT
Not listed Not applicable Interventional

Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair

NCT01589796
View directory record Official record
Conditions
Abdominal Muscles/Ultrasonography, Adult, Ambulatory Surgical Procedures, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage, Ropivacaine/Analogs & Derivatives, Hernia, Inguinal/Surgery, Humans, Nerve Block/Methods, Pain Measurement/Methods, Pain, Postoperative/Prevention & Control, Ultrasonography, Interventional
Interventions
TAP block
Procedure
Lead sponsor
Stamford Anesthesiology Services, PC
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Oct 19, 2026, 11:01 PM EDT