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ClinicalTrials.gov public records Last synced Nov 11, 2026, 12:21 AM EST

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Showing 1–24 of 213 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Local Anesthetics Clear all

Conditions: Dental Pain
Interventions: Non-buffered Anesthetic, Buffered Anesthetic, Onset; Drug · Device
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 2 Years to 6 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Cleveland, Ohio

Conditions: Healthy, Inflammation, Mouth Disease, Pain
Interventions: Not listed
Lead sponsor: National Institute of Dental and Craniofacial Research (NIDCR); NIH
Eligibility: Not listed
Enrollment: 275 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2002
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Lumbar Spine Disease, Lumbar Disc Herniation, Lumbar Spinal Stenosis
Interventions: Preoperative fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon; Procedure
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 232 participants
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
Interventions: Erector Spinae Plane Block, Subcutaneous Anesthesia; Procedure
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Analgesia, Surgery
Interventions: TAP Anesthesia, Surgeon-Initiated Local Anesthetic; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Postoperative Pain
Interventions: Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA); Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Low Back Pain
Interventions: Adhesiolysis; Procedure
Lead sponsor: Pain Management Center of Paducah; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Paducah, Kentucky

Conditions: Anesthesia, Local
Interventions: AG-920, Proparacaine Ophthalmic; Drug
Lead sponsor: American Genomics, LLC; Industry
Eligibility: Up to 10 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: McAllen, Texas

Conditions: Postoperative Pain
Interventions: Bupivacaine, Lidocaine, Thrombin, Tranexamic acid, Aminocaproic acid; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Pain, Postoperative, Delirium, Anesthesia, Local
Interventions: Ropivacaine HCL, sodium chloride; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 50 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Abscess
Interventions: Lidocaine, Vapocoolant; Drug
Lead sponsor: Albert Einstein Healthcare Network; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Liposomal bupivacaine, 266mg, Bupivacaine 0.5 % with Epinephrine, Ketorolac 30mg, Morphine 10mg, Bupivacaine 0.25% with Epinephrine; Drug
Lead sponsor: Holy Cross Hospital, Florida; Other
Eligibility: 18 Years to 88 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Rotator Cuff Injuries, Shoulder Disease, Hallux Valgus, Ankle Arthropathy
Interventions: Experimental Treatment; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Complex Regional Pain Syndromes
Interventions: Ketamine, Midazolam, Normal Saline; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2099
U.S. locations: 1
States / cities: Stanford, California

Conditions: Oncologic Surgery, Cancer, Cancer Surgery, Hepatic Cancer, Gastric (Cardia, Body) Cancer, Biliary Tract Cancer, Pancreatic Cancer Resectable, Gynecologic Cancers, Gastrointestinal Cancers, Colorectal Cancer, Minimally Invasive Surgical Procedures
Interventions: Local Anesthesia, Laparoscopic Transversus Abdominis Plane block; Procedure
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 18 Years to 89 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Osteoarthritis, Arthroplasty
Interventions: Ropivacaine with NaCl, Epinephrine, Morphine, Ketorolac Tromethamine, Ropivacaine; Drug
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Hemorrhoids
Interventions: placement of a continuous infusion pump, continuous infusion pump of bupivacaine; Device
Lead sponsor: United States Naval Medical Center, Portsmouth; Federal
Eligibility: 18 Years to 99 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Portsmouth, Virginia

Conditions: Anesthesia, Upper Extremity Injury
Interventions: Retroclavicular Brachial Plexus Block and Catheter Insertion; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 100 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative, Bruising
Interventions: Tranexamic acid injection; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain, Postoperative, Quality of Life
Interventions: Bupivacaine Local Anesthetic; Drug
Lead sponsor: NYU College of Dentistry; Other
Eligibility: 18 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Bladder Extrophy, Surgery in Children
Interventions: Ropivacaine (Epidural analgesia) intermittent bolus, Ropivacaine (Epidural analgesia) continuous infusion, Chloroprocaine intermittent bolus, Chloroprocaine continuous infusion; Drug
Lead sponsor: Giorgio Veneziano; Other
Eligibility: Up to 18 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Pain, Postoperative
Interventions: ropivacaine; Drug
Lead sponsor: Liberman, Eric, D.O.; Individual
Eligibility: 18 Years and older · Female only
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Livingston, New Jersey

Conditions: Pain, Acute Postoperative, Trauma Injury
Interventions: Continuous Infusion of ropivacaine 0.2%, Titratable Automated Intermittent Boluses of ropivacaine 0.2%; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Appendicitis
Interventions: Ropivacaine, Bupivacaine; Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Not listed
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

Buffered Local Anesthetic

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

Perioperative Local Anesthesia Block in Spine Surgery

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery

PAIN - Postoperative Analgesia INvestigation

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population

Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

Ketamine and Midazolam Infusions for CRPS: Feasibility Study

Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy

Clinical Evaluation of the Ultrasound-Guided Retroclavicular Brachial Plexus Block

Use of Tranexamic Acid in Blepharoplasties

Efficacy of Two Local Anesthetics on Quality of Life After Endodontic Treatment

A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion

Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication

Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia

Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies