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Showing 1–24 of 125 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Loneliness Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Occupational Therapy for Mental Health and Engagement in Neurorehabilitation

NCT07375485
View directory record Official record
Conditions
Acquired Brain Injury, Mental Health, Depressive Symptoms, Anxiety Symptoms, Loneliness
Interventions
Multifaceted implementation program
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Denver, Colorado • Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Loneliness and Health Outcomes in the High Need Population

NCT05484258
View directory record Official record
Conditions
Anxiety, Loneliness, Depression, Alcohol Use Disorder, Utilization, Health Care
Interventions
Shared Medical Visit
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

NCT05451589
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Chronic Pain, Fatigue, Loneliness, Stress, Psychological
Interventions
RESET, Wellness Check Control
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
457 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Results available

The Helping Older People Engage Project: Improving Social Well-Being in Later Life

NCT03343483
View directory record Official record
Conditions
Loneliness, Quality of Life
Interventions
Volunteering, Life Review
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
View directory record Official record
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internet-based Conversational Engagement Clinical Trial

NCT02871921
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
Conversational Engagement
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Jul 21, 2026, 11:16 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Online Mindfulness-Based College for Young Adults

NCT04733300
View directory record Official record
Conditions
Depressive Symptoms, Loneliness, Sedentary Behavior, Mindfulness, Physical Activity, Diet, Sleep, Emotional Regulation, Alcohol Consumption, Youth, Stress, Psychological
Interventions
Mindfulness-Based College for Young Adults, Health Education for Young Adults
Behavioral · Other
Lead sponsor
Eric Loucks
Other
Eligibility
18 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation

NCT03972787
View directory record Official record
Conditions
Loneliness, Mood, Quality of Life
Interventions
Proactive social robot
Device
Lead sponsor
Baycrest
Other
Eligibility
70 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Jul 21, 2026, 11:16 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Social Disconnection Study

NCT06705348
View directory record Official record
Conditions
Social Disconnection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional

Suicide Prevention Among Recipients of Care

NCT04893447
View directory record Official record
Conditions
Suicide, Suicide, Attempted, Suicidal Ideation, Social Support, Secondary Prevention, Patient Care Planning, Outpatients, Outpatient Clinics, Hospital, Mental Health Services, Mental Health, Mental Disorder, Loneliness, Emergency Service, Hospital, Depressive Disorder, Depression, Continuity of Patient Care, Ambulatory Care, Adolescent, Adult, Crisis Intervention
Interventions
SPI+, SP+CC (Caring Contacts)
Behavioral
Lead sponsor
St. Luke's Health System, Boise, Idaho
Other
Eligibility
12 Years and older
Enrollment
1,520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jul 21, 2026, 11:16 AM EDT
Recruiting Not applicable Interventional

Increasing Veterans' Social Engagement and Connectedness

NCT06467214
View directory record Official record
Conditions
Social Isolation
Interventions
CONNECTED, VET BEFRIENDING
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional

The Impact of Social Phone Calls on Adults Who Have Had a Stroke

NCT05793255
View directory record Official record
Conditions
Stroke
Interventions
Social Phone Calls
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Jul 21, 2026, 11:16 AM EDT
Recruiting Not applicable Interventional

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

NCT06919094
View directory record Official record
Conditions
Apathy, Loneliness, Reminiscence Therapy
Interventions
Life Story Club
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional

Mindful Response to Adversity: A Brief Stress Resilience Training

NCT04064372
View directory record Official record
Conditions
Loneliness, Depression
Interventions
Mindful response to adversity brief training, Strengths-based response to adversity brief training
Behavioral
Lead sponsor
Carnegie Mellon University
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Jul 21, 2026, 11:16 AM EDT
Enrolling by invitation Not applicable Interventional

Adapting and Pilot Testing a Loneliness Intervention for Cancer Survivors

NCT07418437
View directory record Official record
Conditions
Cancer Survivorship, Loneliness
Interventions
Social Prescribing Group, Usual Care
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Results available

Connect for Caregivers

NCT04919070
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Connect for Caregivers
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2022 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Results available

Mindfulness to Reduce Loneliness in Older Caregivers

NCT04560088
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Mindfulness, Breathing
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Results available

Engage Psychotherapy to Promote Connectedness in Caregivers

NCT04176601
View directory record Official record
Conditions
Loneliness, Social Isolation, Caregiver Burnout
Interventions
Engage coaching
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness-Based College: Stage 1

NCT03124446
View directory record Official record
Conditions
Diet Habit, Physical Activity, Sleep, Loneliness, Emotional Regulation, Alcohol Consumption, Youth, Stress, Psychological
Interventions
Mindfulness-Based College, Enhanced Usual Care Control
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 28 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 11, 2019 · Synced Jul 21, 2026, 11:16 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Loneliness and Social Connection in Cardiovascular Disease

NCT04195620
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
High self-disclosure, Low self-disclosure
Other
Lead sponsor
Morehead State University
Other
Eligibility
18 Years to 25 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Morehead, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Jul 21, 2026, 11:16 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

How is Social Connection Represented in the Brain?

NCT04577911
View directory record Official record
Conditions
Loneliness
Interventions
Basic Science Experiment
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intelligent Personal Assistant for Managing Depression in Homebound Older Adults

NCT04900272
View directory record Official record
Conditions
Aging, Physical Dependence
Interventions
VIPA and companion booklet
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Jul 21, 2026, 11:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Video Chat During Meals to Improve Nutritional Intake in Older Adults

NCT04862312
View directory record Official record
Conditions
Malnutrition, Loneliness
Interventions
VideoDine
Behavioral
Lead sponsor
Cornell University
Other
Eligibility
60 Years to 95 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2022 · Synced Jul 21, 2026, 11:16 AM EDT