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Showing 1–24 of 129 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Loneliness Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Keep Social Study for Young Adults

NCT07005817
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Experimental Health Communication, Simulated Social Media Platform Only
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 29 Years
Enrollment
1,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatology

NCT04440098
View directory record Official record
Conditions
Loneliness, Depression, Anxiety, Alcohol Abuse, Drug Abuse
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 35 Years
Enrollment
1,008 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Sep 4, 2026, 3:24 PM EDT
Recruiting Not applicable Interventional

Intervening on Opioid Use and Loneliness

NCT06458335
View directory record Official record
Conditions
Opioid Use Disorder, Loneliness, Social Isolation
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Not yet recruiting Not applicable Interventional

Comparing the Impact of Peer Support vs. Staff-Delivered Transportation Interventions for Young Adults With Intellectual and Developmental Disabilities.

NCT07505121
View directory record Official record
Conditions
Intellectual Disability, Mild to Moderate, Developmental Disability
Interventions
Ready to Ride - Standard Delivery, Ready to Ride - Peer Support Delivery
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 27 Years
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Gainesville, Florida • Minneapolis, Minnesota • Durham, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Smartphone Intervention for Relational and Mental Well Being

NCT04629755
View directory record Official record
Conditions
Depression, Loneliness, Relation, Interpersonal, Covid19
Interventions
Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,765 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 4, 2026, 3:24 PM EDT
Completed No phase listed Observational

The Impact of Starbright World on Children Being Treated at the NIH

NCT00001816
View directory record Official record
Conditions
Child, Hospitalized
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 4, 2026, 3:24 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Longitudinal Study of Neighborhood Social Event Attendance at Renovated Parks and Changes in Sleep, Stress, and Well-being

NCT07699588
View directory record Official record
Conditions
Sleep, Well-being, Mood, Mental Health, Stress (Psychology), Quality of Life, Loneliness
Interventions
Community Park Event Participation
Behavioral
Lead sponsor
City University of New York, School of Public Health
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment

NCT03590327
View directory record Official record
Conditions
Apathy, Mild Cognitive Impairment, Transcranial Magnetic Stimulation, Loneliness, COVID, Neuropsychiatric Symptoms
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a Telephone Reminiscence Program

NCT05977608
View directory record Official record
Conditions
Mental Health, Loneliness, Social Isolation
Interventions
Telephone Reminiscence Intervention
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Results available

Technology and Family Thriving Study

NCT05150990
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Caregiver Burnout, Quality of Life, Mental Health Wellness 1, Loneliness, Family Relationship
Interventions
Virtual Reality, Video Chat
Behavioral
Lead sponsor
University of California, Santa Barbara
Other
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
27
States / cities
Calabasas, California • Camarillo, California • Goleta, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional

Alcohol Cessation Among Head and Neck Cancer Survivors

NCT05570851
View directory record Official record
Conditions
Head and Neck Cancer, Alcohol Use, Unspecified
Interventions
Alcohol Cessation Text Messages, Usual Care
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Not listed Not applicable Interventional

Virtual Yoga for Social Isolation and Loneliness in Rural Veterans

NCT05431166
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Virtual Yoga at First 8 weeks, Virtual Yoga at Second 8 weeks
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 88 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Sep 4, 2026, 3:24 PM EDT
Recruiting Not applicable Interventional

A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults

NCT06919094
View directory record Official record
Conditions
Apathy, Loneliness, Reminiscence Therapy
Interventions
Life Story Club
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Recruiting Not applicable Interventional

Bridge to Belonging: Peer Led Intervention to Reduce Loneliness and Depression Among Older Gay and Bisexual Men

NCT07762066
View directory record Official record
Conditions
HIV
Interventions
B2B Intervention, Control condition
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional

Empower@Home:Connected - Feasibility and Preliminary Effect Study

NCT05732740
View directory record Official record
Conditions
Depression, Loneliness, Social Isolation, Depressive Disorder, Mood Disorders, Mental Disorder
Interventions
Empower@Home:Connected
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Sep 4, 2026, 3:24 PM EDT
Enrolling by invitation Not applicable Interventional

Evaluating an Enhanced Home-delivered Meal Program on Older Adults' Health and Well-being

NCT06401694
View directory record Official record
Conditions
Diet, Healthy, Food Insecurity, Loneliness, Quality of Life
Interventions
Home-delivered meals, Wellness check and socialization visit, Community Health Worker calls, Supplemental grocery bag
Other · Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
1,640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Results available

Engage Psychotherapy to Promote Connectedness in Caregivers

NCT04176601
View directory record Official record
Conditions
Loneliness, Social Isolation, Caregiver Burnout
Interventions
Engage coaching
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Loneliness and Social Connection in Cardiovascular Disease

NCT04195620
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
High self-disclosure, Low self-disclosure
Other
Lead sponsor
Morehead State University
Other
Eligibility
18 Years to 25 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Morehead, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Results available

Pain and Loneliness

NCT05455476
View directory record Official record
Conditions
Chronic Pain
Interventions
CBT for Loneliness, CBT for Chronic Pain
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
View directory record Official record
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Results available

The Helping Older People Engage Project: Improving Social Well-Being in Later Life

NCT03343483
View directory record Official record
Conditions
Loneliness, Quality of Life
Interventions
Volunteering, Life Review
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Social Factors in the Mental Health of Young Adults: Bridging Psychological and Network Analysis

NCT04771195
View directory record Official record
Conditions
Anxiety, Depression, Loneliness, Stress
Interventions
Examination of students' naturally occurring social ties
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
9,941 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 4, 2026, 3:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preliminary Efficacy of a One-Session Mindfulness Telehealth Intervention for Loneliness

NCT04414826
View directory record Official record
Conditions
Loneliness
Interventions
Mindfulness Alone (MO) Intervention, Mindfulness + Compassion Intervention (MC)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 70 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 4, 2026, 3:24 PM EDT
Not listed Not applicable Interventional

Robot-assisted Cognitive Training for Lonely Older Adults With Mild Cognitive Impairment (MCI)

NCT04051918
View directory record Official record
Conditions
Cognitive Change, Cognitive Impairment, Mild, Aging
Interventions
Piano Training
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Sep 4, 2026, 3:24 PM EDT