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ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:01 PM EDT

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Showing 97–120 of 132 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Loneliness Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internet-based Conversational Engagement Clinical Trial

NCT02871921
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
Conversational Engagement
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Social Activity, Loneliness and Stigma During COVID-19 Outbreak

NCT04734171
View directory record Official record
Conditions
Covid19, Fear, Loneliness
Interventions
Digital social activity video intervention, Informational sheet, Stigma awareness video intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Phase 2 Interventional

Social Connections and Healthy Aging (The Senior Connection)

NCT01408654
View directory record Official record
Conditions
Suicidal Ideation, Depression
Interventions
Peer Companionship
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2016 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Loneliness of Older Adults in Long Term Care Facilities Through Collaborative Augmented Realities

NCT06179225
View directory record Official record
Conditions
Loneliness
Interventions
HMD AR, 2-D AV
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional

Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial

NCT05484297
View directory record Official record
Conditions
Loneliness
Interventions
Crisis Caring Contacts post cards, Control post cards
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
974 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Ann Arbor, Michigan • Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Results available

Mindfulness to Reduce Loneliness in Older Caregivers

NCT04560088
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Mindfulness, Breathing
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 19, 2026, 10:01 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

BLOOM: Boldly Living outdOOrs for Mental Health

NCT05973123
View directory record Official record
Conditions
Anxiety, Stress Disorder, Posttraumatic, Loneliness, Adverse Childhood Experiences
Interventions
Group Nature Outings, Family Outings
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Years to 12 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Recruiting Not applicable Interventional

Engage Coaching (R33 Phase)

NCT07488559
View directory record Official record
Conditions
Social Connection, Loneliness, Suicide Ideation, Social-emotional Quality of Life
Interventions
Social Engage Coaching (S-ENG)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Oct 19, 2026, 10:01 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Commensality Groups: A Professional Fulfillment Intervention for Medical Students in Their Clinical Years

NCT06656650
View directory record Official record
Conditions
Professional Fulfillment, Burnout, Social Isolation or Loneliness
Interventions
Commensality groups
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

NCT04940663
View directory record Official record
Conditions
Psychosis, Schizophrenia
Interventions
EMA
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Recruiting Not applicable Interventional

Fostering Agricultural Relationships and Meaning - Thriving on Kinship

NCT07218965
View directory record Official record
Conditions
Loneliness, Social Isolation, Rural Health
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 19, 2026, 10:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Connection Collective for Older Adults in Subsidized Housing

NCT07863583
View directory record Official record
Conditions
Social Isolation in Older Adults, Social Isolation or Loneliness, Social Isolation
Interventions
Social Connection Collective: Open-Label Pilot, Social Connection Collective: Pilot
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
62 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Enrolling by invitation Not applicable Interventional

Evaluating an Enhanced Home-delivered Meal Program on Older Adults' Health and Well-being

NCT06401694
View directory record Official record
Conditions
Diet, Healthy, Food Insecurity, Loneliness, Quality of Life
Interventions
Home-delivered meals, Wellness check and socialization visit, Community Health Worker calls, Supplemental grocery bag
Other · Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
1,640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Mobile App to Address Student Loneliness

NCT04164654
View directory record Official record
Conditions
Loneliness
Interventions
Loneliness Intervention
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 25 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional

Alcohol Cessation Among Head and Neck Cancer Survivors

NCT05570851
View directory record Official record
Conditions
Head and Neck Cancer, Alcohol Use, Unspecified
Interventions
Alcohol Cessation Text Messages, Usual Care
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CommunityRx-Dementia + Peer Navigation (CRxDpeer)

NCT07346183
View directory record Official record
Conditions
Alzheimer s Disease, Dementia, Caregiver, Loneliness, Health-Related Social Needs, Social Care, Healthcare Utilization, End of Life Care, Caregiver Burden, Anxiety, Stress, Depression, Self-Efficacy, Peer Support, Implementation Science, Advance Care Planning
Interventions
CommunityRx-Dpeer
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional

Suicide Prevention Among Recipients of Care

NCT04893447
View directory record Official record
Conditions
Suicide, Suicide, Attempted, Suicidal Ideation, Social Support, Secondary Prevention, Patient Care Planning, Outpatients, Outpatient Clinics, Hospital, Mental Health Services, Mental Health, Mental Disorder, Loneliness, Emergency Service, Hospital, Depressive Disorder, Depression, Continuity of Patient Care, Ambulatory Care, Adolescent, Adult, Crisis Intervention
Interventions
SPI+, SP+CC (Caring Contacts)
Behavioral
Lead sponsor
St. Luke's Health System, Boise, Idaho
Other
Eligibility
12 Years and older
Enrollment
1,520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 19, 2026, 10:01 PM EDT
Not listed Not applicable Interventional

Robot-assisted Cognitive Training for Lonely Older Adults With Mild Cognitive Impairment (MCI)

NCT04051918
View directory record Official record
Conditions
Cognitive Change, Cognitive Impairment, Mild, Aging
Interventions
Piano Training
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Oct 19, 2026, 10:01 PM EDT
Not listed Not applicable Interventional

The Impact of Social Phone Calls With Isolated Older Adults Receiving Protective Services for Abuse, Neglect and/or Exploitation

NCT05026762
View directory record Official record
Conditions
Senior Abuse
Interventions
Treatment
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 30, 2021 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility of Remote Home Support Coaches (SOCIAL Study)

NCT04772820
View directory record Official record
Conditions
Malnutrition, Isolation, Depression, Anxiety, Sedentary Behavior, Loneliness
Interventions
Telephone-based coaching
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
75 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Oct 19, 2026, 10:01 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation

NCT05831475
View directory record Official record
Conditions
Social Isolation, Loneliness, Intergenerational Relations
Interventions
Intergenerational Virtual Paired Exercise, Peer Virtual Paired Exercise
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional

The Impact of Social Phone Calls on Adults Who Have Had a Stroke

NCT05793255
View directory record Official record
Conditions
Stroke
Interventions
Social Phone Calls
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 19, 2026, 10:01 PM EDT
Completed Not applicable Interventional Results available

Modifiers and Mechanisms of Loneliness Interventions

NCT05812989
View directory record Official record
Conditions
Loneliness
Interventions
Social Engage Coaching, Connect for Caregivers
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 19, 2026, 10:01 PM EDT