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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Long-standing Persistent Atrial Fibrillation Clear all
Active, not recruiting Not applicable Interventional

AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

NCT03732794
View directory record Official record
Conditions
Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Interventions
AtriCure CryoICE & AtriClip LAA Exclusion
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
15
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Chicago, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Not applicable Interventional Results available

Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach

NCT02393885
View directory record Official record
Conditions
Atrial Fibrillation, Persistent or Longstanding Persistent Atrial Fibrillation
Interventions
AtriCure Bipolar System and AtriClip® PRO LAA Exclusion System, Endocardial Ablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
15
States / cities
Long Beach, California • Los Angeles, California • Oakland, California + 11 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Jun 10, 2026, 6:17 PM EDT
Enrolling by invitation No phase listed Observational

A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF

NCT06335082
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulsed Field Ablation
Device
Lead sponsor
Heart Rhythm Clinical and Research Solutions, LLC
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
35
States / cities
Birmingham, Alabama • Jonesboro, Arkansas • San Francisco, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 6:17 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation

NCT02019238
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulmonary Vein Isolation procedure
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jun 10, 2026, 6:17 PM EDT
Active, not recruiting Phase 4 Interventional

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

NCT06765356
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Farapulse Catheter System, Low-dose Colchicine
Device · Drug
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
9
States / cities
Jonesboro, Arkansas • Ventura, California • Naples, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Not applicable Interventional Results available

Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP)

NCT01661205
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Ablation procedure staged catheter ablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
4
States / cities
Stanford, California • Colorado Springs, Colorado • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Phase 3 Interventional

Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation

NCT01173809
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Amiodarone
Drug
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Jun 10, 2026, 6:17 PM EDT
Not listed Not applicable Interventional

Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Phase 3 Interventional

Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation

NCT01362738
View directory record Official record
Conditions
Persistent Atrial Fibrillation
Interventions
RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Jun 10, 2026, 6:17 PM EDT
Withdrawn Not applicable Interventional

CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF

NCT04239534
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Convergence Of Epicardial And Endocardial RF Ablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
8
States / cities
Birmingham, Alabama • Huntsville, Alabama • Washington D.C., District of Columbia + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Not applicable Interventional Results available

Comparison of Pulmonary Vein Ablation With or Without Left Atrial Posterior Wall Ablation for Persistent AF (PIVoTAL)

NCT03057548
View directory record Official record
Conditions
Atrial Fibrillation Chronic, Persistent Atrial Fibrillation
Interventions
Cryo or Radiofrequency (RF) Ablation only of Pulmonary Veins, Cryo or RF Ablation of Pulmonary Veins plus Ablation of the PLAW
Procedure
Lead sponsor
Arash Aryana, MD
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jun 10, 2026, 6:17 PM EDT
Not listed No phase listed Observational

Does Atrial Fibrillation (AF) Termination Without Additional Ablation Influence Outcome?

NCT01696344
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
PVAI, PVAI + ablation of extraPV triggers
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Phase 3 Interventional

Outcome of Different Ablation Strategies In Persistent and Long-Standing Persistent Atrial Fibrillation

NCT02533843
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
radiofrequency catheter ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Jun 10, 2026, 6:17 PM EDT
Completed Not applicable Interventional

LS-PersAFone: Pulsed Field Ablation for Long-Standing Persistent Atrial Fibrillation

NCT06128174
View directory record Official record
Conditions
Long-standing Persistent AF
Interventions
Farawave PFA catheter
Device
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 10, 2026, 6:17 PM EDT
Completed No phase listed Observational

The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation

NCT01148914
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Inflammatory biomarkers
Other
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2012 · Synced Jun 10, 2026, 6:17 PM EDT