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Showing 1–24 of 868 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Low Back Ache Clear all
Completed Not applicable Interventional

Manual Unloading of the Lumbar Spine: Can it Predict Responders to Mechanical Traction?

NCT02026076
View directory record Official record
Conditions
Low Back Pain
Interventions
mechanical lumbar traction
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Optimize Low Back Pain

NCT03859713
View directory record Official record
Conditions
Low Back Pain, Chronic Pain
Interventions
Physical Therapy, Cognitive Behavioral Therapy, Mindfulness, Phase I Treatment, Phase II Switching
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 64 Years
Enrollment
749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
Baltimore, Maryland • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

VIA Disc NP Registry 3.0

NCT06345690
View directory record Official record
Conditions
Discogenic Pain, Back Pain, Back Pain, Low
Interventions
VIA Disc NP
Other
Lead sponsor
VIVEX Biologics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
24
States / cities
Little Rock, Arkansas • Englewood, Colorado • Grand Junction, Colorado + 21 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Phase 2 Interventional Results available

Optimization of Spinal Manipulative Therapy Protocols

NCT02868034
View directory record Official record
Conditions
Low Back Pain
Interventions
SMT, Mobilizing Exercises, Activation Exercises, SMT extended
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Phase 2 Interventional

Psychosocial Treatment for Acute Low Back Pain

NCT00000418
View directory record Official record
Conditions
Acute Low Back Pain
Interventions
Psychosocial intervention
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1977 – 2001
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 5, 2013 · Synced Sep 4, 2026, 11:40 AM EDT
Completed No phase listed Observational

Radiofrequency Nerve Ablation Versus Sham to Treat Chronic Low Back Pain Caused by Sacroiliac Joint Dysfunction

NCT01104051
View directory record Official record
Conditions
Sacroiliac Joint Dysfunction
Interventions
Not listed
Lead sponsor
Coastal Orthopedics & Sports Medicine
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Jul 28, 2015 · Synced Sep 4, 2026, 11:40 AM EDT
Not yet recruiting Not applicable Interventional

Algorithm-informed Decision-making to Advance Pain Treatment

NCT07731750
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Algorithmically informed randomization (taking into account phenotypes), Physical Therapy (PT) and Exercise, Cognitive-Behavioral Therapy for Pain (PRISM-CBT), mHealth Acupressure Self-Management:, Duloxetine
Device · Behavioral · Drug
Lead sponsor
University of Michigan
Other
Eligibility
25 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Not listed Phase 4 Interventional

A Prospective Study of the InterFuse T(tm),

NCT02678130
View directory record Official record
Conditions
Low Back Pain
Interventions
InterFuse T, Standard of Care TLIF (Stryker AVS Unilif)
Device
Lead sponsor
Vertebral Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Development and Feasibility of Mindfulness Based Pain Reduction

NCT04980612
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Mindfulness Based Pain Reduction, Mindfulness Based Stress Reduction
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Phase 4 Interventional

Study to Evaluate Ferris PainWrap in the Treatment of Chronic Low Back Pain

NCT00364065
View directory record Official record
Conditions
Low Back Pain
Interventions
Ferris PainWrap
Device
Lead sponsor
Pain and Rehabilitation Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 17, 2007 · Synced Sep 4, 2026, 11:40 AM EDT
Terminated Phase 4 Interventional Results available

Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain

NCT03891264
View directory record Official record
Conditions
Back Pain, Low
Interventions
Cannabidiol
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Sep 4, 2026, 11:40 AM EDT
Completed No phase listed Observational Results available

Examining Racial and SocioEconomic Disparities (ERASED) in Chronic Low Back Pain Study

NCT03338192
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
QST
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 85 Years
Enrollment
281 participants
Timeline
2017 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Phase 4 Interventional Results available

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT01455519
View directory record Official record
Conditions
Low Back Pain
Interventions
Hydromorphone ER, Sugar pill
Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2017 · Synced Sep 4, 2026, 11:40 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multiplanar Lumbopelvic Control in Patients With Low Back Pain

NCT02089321
View directory record Official record
Conditions
Low Back Pain
Interventions
Not listed
Lead sponsor
Regis University
Other
Eligibility
18 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 16, 2014 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Phase 3 Interventional Results available

Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects

NCT01675167
View directory record Official record
Conditions
Low Back Pain
Interventions
Buprenorphine, Placebo
Drug
Lead sponsor
BioDelivery Sciences International
Industry
Eligibility
18 Years and older
Enrollment
815 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
66
States / cities
Birmingham, Alabama • Haleyville, Alabama • Mobile, Alabama + 57 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Z-Joint Changes in Low Back Pain Following Adjusting

NCT00284063
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Low back adjustment and MRI, MRI
Procedure
Lead sponsor
National University of Health Sciences
Other
Eligibility
21 Years to 69 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Sep 4, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional

Discogen for Low Back Pain

NCT06611397
View directory record Official record
Conditions
Disc Herniation
Interventions
Discogen Low pulsed ultrasound treatment, Discogen Sham Treatment
Device
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

A Placebo-Controlled Study Assessing Lateral Branch Radiofrequency Denervation for Sacroiliac (SI) Joint Pain

NCT00373724
View directory record Official record
Conditions
Low Back Pain
Interventions
radiofrequency denervation
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 8, 2008 · Synced Sep 4, 2026, 11:40 AM EDT
Recruiting No phase listed Observational

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

NCT06827262
View directory record Official record
Conditions
Chronic Low-back Pain, Vertebrogenic Pain Syndrome
Interventions
Intracept™ Intraosseous Nerve Ablation
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2034
U.S. locations
21
States / cities
Flagstaff, Arizona • Phoenix, Arizona • Larkspur, California + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response

NCT00601341
View directory record Official record
Conditions
Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
Interventions
lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Sep 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Yoga vs. Education for Veterans With Chronic Low Back Pain

NCT02224183
View directory record Official record
Conditions
Recurrent Low Back Pain
Interventions
Education, Yoga
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2016 · Synced Sep 4, 2026, 11:40 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Regional Interdependence of the Shoulders and Hips in Gymnasts With Low Back Pain

NCT02201966
View directory record Official record
Conditions
Low Back Pain
Interventions
Not listed
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
7 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Powell, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 6, 2015 · Synced Sep 4, 2026, 11:40 AM EDT
Active, not recruiting Not applicable Interventional

Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)

NCT07033195
View directory record Official record
Conditions
Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)
Interventions
Skills-based Virtual Reality Therapy, Distraction-based Virtual Reality Therapy
Device
Lead sponsor
CognifiSense Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 4, 2026, 11:40 AM EDT
Active, not recruiting Not applicable Interventional Results available

EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain

NCT05263037
View directory record Official record
Conditions
Chronic Low-back Pain, Anxiety, Depression
Interventions
EaseVRx, Sham VR
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,093 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Van Nuys, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 4, 2026, 11:40 AM EDT