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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Low Back Pain, Mechanical Clear all
Withdrawn Not applicable Interventional

Effectiveness of Mechanical Decompression for Low Back Pain Relief

NCT00704210
View directory record Official record
Conditions
Low Back Pain
Interventions
SpineMed Table, Cert HealthSciences LLC
Device
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2016 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 3 Interventional Results available

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

NCT03581123
View directory record Official record
Conditions
Acute Pain, Low Back Pain, Mechanical
Interventions
Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM, Standard Medical Care (SMC)
Behavioral · Other · Combination Product + 1 more
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
3
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

A Trial Comparing Mechanical Diagnosis and Treatment to Manual Therapy

NCT03049644
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Mechanical Diagnosis and Therapy, Manual Therapy
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Jul 23, 2026, 2:08 AM EDT
Not listed Phase 3 Interventional

Wallis Mechanical Normalization System for Low Back Pain

NCT00134537
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization, Conservative Care
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
17
States / cities
Phoenix, Arizona • Beverly Hills, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2011 · Synced Jul 23, 2026, 2:08 AM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Jul 23, 2026, 2:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Reliability of Spine Mobilization in Low Back Pain

NCT07582705
View directory record Official record
Conditions
Low Back Pain, Low Back Ache, Low Back Pain, Mechanical, Low Back Pain, Posterior Compartment, Low Back Pain, Postural, Low Back Pain, Recurrent, Low Backache, Lower Back Pain, Lower Back Pain Chronic, Mechanical Low Back Pain, Postural Low Back Pain, Recurrent Low Back Pain
Interventions
Spinal mobilization
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Strain-Counterstrain Treatment of Piriformis Pain

NCT05023005
View directory record Official record
Conditions
Low Back Pain, Mechanical, Piriformis Syndrome, Somatic Dysfunction of Sacral Region (Finding)
Interventions
Strain-Counterstrain treatment of piriformis muscle
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lower Back Biomechanics in Veterans With Non-Specific Low Back Pain

NCT04249453
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Automatic Thermomechanical Massage Bed for Acute Pain Relief for Chronic Nonspecific Low Back Pain

NCT06769321
View directory record Official record
Conditions
Chronic Non-specific Low Back Pain
Interventions
Automatic Thermo-mechanical Massage Bed
Device
Lead sponsor
The City College of New York
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Not listed Not applicable Interventional

Prescriptive Mobilization Versus a Pragmatic Mobilization

NCT01940744
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Prescriptive Mobilization, Pragmatic Mobilization
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Des Moines, Iowa • North Canton, Ohio • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 2 Interventional

Chiropractic and Exercise for Seniors With Low Back Pain

NCT00269321
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic Manual treatment + home exercise (procedure+behavior), Supervised rehabilitative exercise+home exercise, Home exercise
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Activator Manipulation Versus Manual Side Posture Manipulation in Patients With Low Back Pain

NCT00497861
View directory record Official record
Conditions
Back Pain
Interventions
Activator Methods Chiropractic Technique
Procedure
Lead sponsor
Cleveland Chiropractic College
Other
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 8, 2007 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Phase 2 Interventional

Thrust Manipulation Versus Non-Thrust Manipulation

NCT01438203
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Thrust manipulation, Non-thrust manipulation
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
North Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2012 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Manual Unloading of the Lumbar Spine: Can it Predict Responders to Mechanical Traction?

NCT02026076
View directory record Official record
Conditions
Low Back Pain
Interventions
mechanical lumbar traction
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Terminated Not applicable Interventional

Clinical Prediction Rule for Clinical Lumbar Instability

NCT01085448
View directory record Official record
Conditions
Low Back Pain
Interventions
Core Stabilization
Other
Lead sponsor
Drexel University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Z-Joint Changes in Low Back Pain Following Adjusting

NCT00284063
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Low back adjustment and MRI, MRI
Procedure
Lead sponsor
National University of Health Sciences
Other
Eligibility
21 Years to 69 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Spinal Control During Functional Activities to Improve Low Back Pain Outcomes

NCT02027623
View directory record Official record
Conditions
Mechanical Low Back Pain, Chronic Low Back Pain
Interventions
Motor skill training, Strength and flexibility exercise
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Hormones, Outcomes, and Pain Pathways in Exercise Study

NCT07579182
View directory record Official record
Conditions
Breast Pain, Mastalgia, Back Pain, Back Pain, Low, Neck Pain, Chest Pain, Activity, Motor, Healthy Aging, Weight, Body, Inflammation, Gonadal Steroid Hormones, Neuronal Plasticity, Neuromuscular Manifestations
Interventions
Interventional Sports bra
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dry Needling to the Multifidus Muscle in Subjects With Low Back Pain

NCT02284724
View directory record Official record
Conditions
Low Back Pain, Mechanical
Interventions
Dry Needling, Sham Needling
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Comparing Dry Needling to Manual Therapy for Patients With Mechanical Low Back Pain

NCT02312895
View directory record Official record
Conditions
Low Back Pain
Interventions
Manual therapy, Dry needling, Home Exercise Program
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years to 70 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Jul 23, 2026, 2:08 AM EDT
Recruiting Phase 1 Interventional

Adia Med of Winter Park LLC Lower Back Pain Research Study

NCT07587047
View directory record Official record
Conditions
Chronic Mechanical Lower Back Pain, Lower Back Pain, Chronic Lower Back Pain
Interventions
Umbilical Cord Blood-Derived Stem Cells and Exosomes, Placebo IV
Biological · Other
Lead sponsor
Adia Med of Winter Park LLC
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Winter Park, Florida
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 23, 2026, 2:08 AM EDT
Withdrawn Not applicable Interventional

Influence of Patient-Informed Choice in a Novel Treatment Model for LBP

NCT01744015
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Patient Decision Making tool, Standard of care
Behavioral · Other
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Emergency Department Digital Pain Self-Management Intervention to Improve Acute Low Back Pain Outcomes

NCT06360341
View directory record Official record
Conditions
Low Back Pain, Mechanical, Acute Pain
Interventions
Emergency Department Digital Pain Self-Management Intervention (EDPSI), Routine Discharge Care
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Jul 23, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

NCT03176654
View directory record Official record
Conditions
Neck Pain, Posterior
Interventions
HVLAT manipulation, Sham HVLAT manipulation
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Jul 23, 2026, 2:08 AM EDT