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ClinicalTrials.gov public records Last synced Oct 24, 2026, 12:00 PM EDT

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Showing 1–24 of 4,843 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Low Mood Clear all
Completed No phase listed Observational

Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants

NCT00360256
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional

A Study of the Cost Effectiveness of Generalist Care Managers for Depression Treatment in Medicaid Recipients

NCT00373477
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Generalist Care Manager vs Usual Care
Procedure
Lead sponsor
University of North Carolina
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
2
States / cities
Asheville, North Carolina • Marshall, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 8, 2006 · Synced Oct 24, 2026, 12:00 PM EDT
Recruiting Not applicable Interventional

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

NCT06132581
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4, Theta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4, Sham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 24, 2026, 12:00 PM EDT
Completed No phase listed Observational

Quality of Life in African-American or Caucasian Female Breast Cancer Survivors

NCT00268502
View directory record Official record
Conditions
Breast Cancer, Cancer Survivor, Depression, Fatigue, Sexual Dysfunction, Sleep Disorders, Spiritual Concerns
Interventions
study of socioeconomic and demographic variables, fatigue assessment and management, management of therapy complications, psychosocial assessment and care, quality-of-life assessment
Other · Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 120 Years · Female only
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Oct 24, 2026, 12:00 PM EDT
Not yet recruiting Not applicable Interventional

Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS)

NCT07793981
View directory record Official record
Conditions
Post Surgical Respiratory Failure, Respiratory Complication, Opioid Induced Respiratory Depression, Respiratory Arrest
Interventions
Linshom Continuous Predictive Respiratory Monitoring
Device
Lead sponsor
Linshom Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
394 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Phase 4 Interventional

Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder

NCT00203528
View directory record Official record
Conditions
Substance Abuse, Bipolar Depression
Interventions
divalproex sodium ER, risperidone
Drug
Lead sponsor
Tuscaloosa Research & Education Advancement Corporation
Other
Eligibility
19 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 19, 2007 · Synced Oct 24, 2026, 12:00 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners

NCT06324383
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder
Interventions
Intervention (videoconferencing)
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Phase 2 Interventional Results available

Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)

NCT00731653
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Combination Product: BCI-024 + BCI-049
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
9
States / cities
Garden Grove, California • San Diego, California • Altanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2013 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Audio-based Mental Health Intervention Study

NCT05555745
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Audio-based behavioral activation intervention, Audio-based self-monitoring intervention
Device
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 12:00 PM EDT
Not listed No phase listed Observational

Advanced Prediction of Respiratory Depression Episode With the Linshom Continuous Predictive Respiratory Sensor

NCT05804175
View directory record Official record
Conditions
Post Surgical Respiratory Failure, Respiratory Complication
Interventions
Linshom Continuous Predictive Respiratory Monitoring
Device
Lead sponsor
Linshom Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Ellicott City, Maryland • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2024 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional

Effect of Yoga on Mood and Quality of Life in Patients With Refractory Epilepsy

NCT02950636
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Yoga
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Oct 24, 2026, 12:00 PM EDT
Terminated Phase 2 Interventional Results available

A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression

NCT04423757
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
BI 1358894, Placebo
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Culver City, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional

e-SMART/EST HIV Telehealth Intervention

NCT05278572
View directory record Official record
Conditions
Hiv, Depression
Interventions
Stress Management and Relaxation Training/Expressive Supportive Therapy (SMART/EST)
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
55 Years to 99 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of The Step Up Wellness Program for People With Depression

NCT00644995
View directory record Official record
Conditions
Depression
Interventions
Step Up Wellness Program, Usual care
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional

Understanding How Cognitive Remediation Works

NCT01683539
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Chronic Mental Disorder, Major Depression, Bipolar Disorder
Interventions
The Thinking Skills for Work Program, The Cognitive Skills for Work Program
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Faith and Community in Action: Increasing Awareness and Management of Depression in African American Communities

NCT03940157
View directory record Official record
Conditions
Depression, Awareness, Self-management
Interventions
Oh Happy Day Class - Still I Rise
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
25 Years to 75 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Oct 24, 2026, 12:00 PM EDT
Not yet recruiting Not applicable Interventional

Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients

NCT07867119
View directory record Official record
Conditions
Traumatic Brain Injuries
Interventions
Therapeutic Benefits of Pareidolia, Active Comparator #1
Behavioral
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 24, 2026, 12:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of the Psychological Development of Children of Parents With and Without Affective Disorders

NCT00001170
View directory record Official record
Conditions
Bipolar Disorder, Involutional Depression, Mood Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
1,045 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1979 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Phase 2 Interventional Results available

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

NCT03460756
View directory record Official record
Conditions
Depressive Disorder, Depression, Depression, Postpartum, Behavioral Symptoms, Mood Disorders, Mental Disorder, Pregnancy Complications, Postpartum Blues, PPD, Postpartum Disorder
Interventions
Ganaxolone, Placebo
Drug
Lead sponsor
Marinus Pharmaceuticals
Industry
Eligibility
18 Years to 48 Years · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
33
States / cities
Glendale, California • Lemon Grove, California • Long Beach, California + 29 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2023 · Synced Oct 24, 2026, 12:00 PM EDT
Recruiting Not applicable Interventional

Telehealth Behavioral Activation for Teens

NCT06273995
View directory record Official record
Conditions
Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
Interventions
Behavioral Activation
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 18 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional Results available

Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients

NCT00151372
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Major Depression
Interventions
Treatment Adherence Intervention, Enhanced Care
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 95 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
3
States / cities
West Haverstraw, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Oct 24, 2026, 12:00 PM EDT
Terminated Phase 2 Interventional Results available

Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer

NCT01680172
View directory record Official record
Conditions
Cancer, Depression, Anxiety
Interventions
Ketamine, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Scottsdale, Arizona • Yuma, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Oct 24, 2026, 12:00 PM EDT
Completed Not applicable Interventional Results available

Telehealth-Based Exercise Program to Treat Fatigue in MS

NCT01198977
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Brief telephone-based counseling, Education counseling
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Oct 24, 2026, 12:00 PM EDT