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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Extremity Amputee Clear all
Recruiting Not applicable Interventional

Enhancing Motor Function in Individuals with Lower Limb Amputation

NCT06638723
View directory record Official record
Conditions
Amputation
Interventions
Balance and fall recovery training
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

LASER Pilot Project

NCT05966636
View directory record Official record
Conditions
Acquired Absence of Lower Limb, Scar Condition and Fibrosis of the Skin
Interventions
Fractional CO2 Laser Ablative Resurfacing
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jun 10, 2026, 7:07 PM EDT
Terminated Not applicable Interventional Results available

Moisture Management Liner At-Home Evaluation

NCT05124873
View directory record Official record
Conditions
Amputation Stump, Amputation, Amputees, Lower Limb Deformity, Prosthesis User, Prosthesis
Interventions
Moisture Management Liner
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Jun 10, 2026, 7:07 PM EDT
Terminated Not applicable Interventional Results available

Neuromodulation in Lower Limb Amputees

NCT04543786
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Hoffman's Reflex
Interventions
Transcutaneous spinal cord stimulation
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of External Mechanical Work Between Different Prosthetic Feet

NCT01340807
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Specialized Functional Prosthetic Training
Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2011 · Synced Jun 10, 2026, 7:07 PM EDT
Enrolling by invitation No phase listed Observational

Kinematics of Ewing Amputees

NCT06371209
View directory record Official record
Conditions
Lower Extremity Amputation, Trans-Tibial Amputation, Traumatic Lower Extremity Amputation, Agonist-Antagonist Myoneural Interface
Interventions
Modified Amputation, Standard Amputation
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Results available

Community Walking Trials: Comparing Prosthetic Feet

NCT03703232
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Investigational prosthetic foot
Device
Lead sponsor
University of Washington
Other
Eligibility
16 Years to 85 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jun 10, 2026, 7:07 PM EDT
Active, not recruiting Not applicable Interventional

VR to Evaluate Phantom Limb Pain

NCT05915065
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions
Coapt Phantom Limb Pain Management System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

NCT00985842
View directory record Official record
Conditions
Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions
Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit

NCT00117793
View directory record Official record
Conditions
Amputation, Diabetes, Leg Injuries, Traumatic Amputations
Interventions
Total Surface Bearing Suction Socket, Vacuum assisted socket system
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 14, 2014 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Jun 10, 2026, 7:07 PM EDT
Recruiting Not applicable Interventional

LIMBER UniLeg: Rapid, On-demand, and Scaled-up Manufacturing of Customized Transtibial Prosthetic Legs for Amputees

NCT06648798
View directory record Official record
Conditions
Amputation of Lower Limb, Prosthesis, Non-inferiority Trial of Prothesis
Interventions
Limber Limb
Device
Lead sponsor
LIMBER Prosthetics & Orthotics Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Jun 10, 2026, 7:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Motor Learning in Individuals With Lower Limb Loss and Chronic Diabetes

NCT03989063
View directory record Official record
Conditions
Amputation, Diabetes Mellitus, Neuropathy, Diabetic
Interventions
Instructions to perform a motor task (external vs. internal focus instructions)
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 27, 2022 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Jun 10, 2026, 7:07 PM EDT
Not yet recruiting Not applicable Interventional

Bio Leg: Advancing Mobility

NCT07613502
View directory record Official record
Conditions
Amputation of Lower Limb Above Knee, Amputee, Amputation
Interventions
Bio-Leg
Device
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 7:07 PM EDT
Not listed Phase 2 Interventional

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

NCT00061217
View directory record Official record
Conditions
Amputation
Interventions
Unrectified prosthetic socket, Rectified prosthetic socket
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jun 10, 2026, 7:07 PM EDT
Recruiting Not applicable Interventional

Feasibility of Neural Feedback for Lower Limb Amputees

NCT03409133
View directory record Official record
Conditions
Amputation
Interventions
Stimulating nerve electrodes and intramuscular recording electrodes
Device
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 10, 2026, 7:07 PM EDT
Completed No phase listed Observational

Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma

NCT02540681
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
10
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Jun 10, 2026, 7:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Novel Transfemoral Prosthetic Socket System

NCT01846845
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Conventional Prosthetic Transfemoral Socket System, Novel Prosthetic transfemoral socket system
Device
Lead sponsor
Ohio Willow Wood
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Columbus, Ohio • Mount Sterling, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2013 · Synced Jun 10, 2026, 7:07 PM EDT
Terminated Not applicable Interventional Results available

Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day

NCT04547582
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
Lee Fisher, PhD
Other
Eligibility
22 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional

Use of Subtle Vibration to Improve Walking Ability by Lower Limb Amputees

NCT00985881
View directory record Official record
Conditions
Amputation, Diabetes Complications
Interventions
Custom prosthetic socket with mechanical vibrators (stochastic resonance), Conventional prosthetic socket (current clinical practice)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Jun 10, 2026, 7:07 PM EDT
Completed Not applicable Interventional Results available

Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health

NCT03927404
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Active vacuum test prosthesis
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Jun 10, 2026, 7:07 PM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Jun 10, 2026, 7:07 PM EDT