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ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:16 PM EDT

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Showing 1–24 of 322 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Fractures Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study

NCT04754087
View directory record Official record
Conditions
Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip, Osteoarthritis, Hip, Osteoarthritis of Hip, Fractures, Hip, Fracture of Hip
Interventions
Vivacit-E and Longevity (HXLPE) Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2033
U.S. locations
6
States / cities
Denver, Colorado • South Bend, Indiana • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures

NCT07280169
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Manual Therapy After Ankle/Hindfoot Fractures

NCT02609347
View directory record Official record
Conditions
Ankle Fracture, Calcaneus Fracture, Talus Fracture, Pilon Fracture
Interventions
Manual Therapy Group, Control Group
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Not applicable Interventional

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

NCT02027896
View directory record Official record
Conditions
Hip Fractures
Interventions
Accelerated medical clearance and surgery
Other
Lead sponsor
McMaster University
Other
Eligibility
45 Years and older
Enrollment
3,001 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
5
States / cities
San Jose, California • Baltimore, Maryland • Burlington, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Oct 21, 2026, 6:16 PM EDT
Not listed Not applicable Interventional

Intramedullary Bone Grafting for Open Tibial Shaft Fractures

NCT03891888
View directory record Official record
Conditions
Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
Interventions
Intramedullary Bone Graft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 21, 2026, 6:16 PM EDT
Not listed No phase listed Observational

A Prospective Study of Early Mechanical Stabilization and Bleeding in Disruption of the Pelvic Ring

NCT03977168
View directory record Official record
Conditions
Pelvic Fracture
Interventions
Application of circumferential pelvic compression (CPC) device
Procedure
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Miami, Florida • Indianapolis, Indiana • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Oct 21, 2026, 6:16 PM EDT
Enrolling by invitation Not applicable Interventional

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

NCT05521958
View directory record Official record
Conditions
Tibial Shaft Fracture, Tibial Plateau Fracture
Interventions
Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Phase 2 Interventional

Essential Amino Acid Supplementation for Femoral Fragility Fractures

NCT06050668
View directory record Official record
Conditions
Femoral Fracture, Fragility Fracture, Muscle Atrophy
Interventions
Essential Amino Acid Supplementation
Combination Product
Lead sponsor
Michael C Willey
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Iowa City, Iowa • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Terminated Not applicable Interventional Results available

Safety Study of Femoral Neck Fracture System

NCT03721835
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
CONQUEST FN Femoral Neck Fracture System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Macon, Georgia • Winston-Salem, North Carolina • Fort Worth, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Randomized, Prospective Comparison of Two Femoral Reaming Systems

NCT00594438
View directory record Official record
Conditions
Femur Fracture
Interventions
Synthes Reamer-Irrigator-Aspirator (RIA), Zimmer Sentinel Reamer
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 26, 2013 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The HIP Impact Protection Program (HIP PRO)

NCT00058864
View directory record Official record
Conditions
Hip Fractures
Interventions
Energy absorbing and distributing trochanteric pad
Device
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
66 Years and older
Enrollment
546 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
4
States / cities
Baltimore, Maryland • Boston, Massachusetts • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 27, 2009 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Accelerated Flap Coverage in Severe Lower Extremity Trauma

NCT06293469
View directory record Official record
Conditions
Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
Interventions
Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
7
States / cities
Sacramento, California • Baltimore, Maryland • Largo, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Phase 2 Interventional Results available

Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery

NCT02152761
View directory record Official record
Conditions
Muscle Wasting (Atrophy) After Hip Fracture Surgery
Interventions
bimagrumab, placebo
Drug · Other
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
60 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • El Cajon, California • Denver, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

NCT07193524
View directory record Official record
Conditions
Tibia Fractures, Trauma (Including Fractures), Surgical Planning
Interventions
3D Fracture Analysis Tool
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 21, 2026, 6:16 PM EDT
Terminated Not applicable Interventional Results available

Clinical Trial Evaluating Acutrak Headless Compression Screw Fixation of Medial Malleolus Fractures

NCT03061279
View directory record Official record
Conditions
Medial Malleolus Fractures
Interventions
Fixation by Acutrak headless screw, Fixation by headed screws, plates, and or wires
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Palo Alto, California • Sacramento, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Not applicable Interventional

Study Evaluating CERAMENT™|G in Open Diaphyseal Tibial Fractures

NCT02820363
View directory record Official record
Conditions
Tibial Fracture
Interventions
CERAMENT|G, SOC treatment
Device · Procedure
Lead sponsor
BONESUPPORT AB
Industry
Eligibility
18 Years to 75 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
17
States / cities
Birmingham, Alabama • Irvine, California • Los Angeles, California + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Oct 21, 2026, 6:16 PM EDT
Active, not recruiting Not applicable Interventional

The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture

NCT04809714
View directory record Official record
Conditions
Hip Fractures, Muscle Atrophy
Interventions
Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Accuro XV Ultrasound Imaging System for BoneEnhance and Fracture Detection Algorithms

NCT07853768
View directory record Official record
Conditions
Fracture Arm, Fracture Leg, Wrist Injury, Ankle Injury
Interventions
Accuro XV Ultrasound Imaging System
Device
Lead sponsor
Rivanna Medical, Inc.
Industry
Eligibility
5 Years and older
Enrollment
25,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
10
States / cities
San Francisco, California • Denver, Colorado • New Haven, Connecticut + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Withdrawn Phase 4 Interventional

Supracondylar Distal Femur Fractures and Abaloparatide

NCT04626141
View directory record Official record
Conditions
Femoral Fractures
Interventions
Abaloparatide, Placebo
Drug
Lead sponsor
Daniel Horwitz
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 21, 2026, 6:16 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

PUSH Plus Protein Pilot for Hip Fracture Patients

NCT03410823
View directory record Official record
Conditions
Hip Fracture
Interventions
PUSH, Protein, Nutrition
Behavioral · Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608
View directory record Official record
Conditions
Osteoporosis, Lower Limb Fracture
Interventions
OPTIONS, Enhanced usual care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
1,344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 21, 2026, 6:16 PM EDT
Enrolling by invitation Not applicable Interventional

G7 Freedom Constrained Vivacit-E Liners

NCT05587244
View directory record Official record
Conditions
Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip
Interventions
Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2038
U.S. locations
10
States / cities
Birmingham, Alabama • Los Angeles, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 21, 2026, 6:16 PM EDT
Completed Phase 4 Interventional Results available

Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients

NCT01904071
View directory record Official record
Conditions
Hip Fracture
Interventions
UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
Procedure · Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 21, 2026, 6:16 PM EDT
Recruiting Not applicable Interventional

Tibial IMN Vs. Tibial Micromotion IMN

NCT06976801
View directory record Official record
Conditions
Tibial Fracture
Interventions
Intramedullary tibial Nail, Intermedullary nail
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 6:16 PM EDT