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Showing 1–24 of 317 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Extremity Fractures. Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The HIP Impact Protection Program (HIP PRO)

NCT00058864
View directory record Official record
Conditions
Hip Fractures
Interventions
Energy absorbing and distributing trochanteric pad
Device
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
66 Years and older
Enrollment
546 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
4
States / cities
Baltimore, Maryland • Boston, Massachusetts • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 26, 2009 · Synced Jul 23, 2026, 10:45 PM EDT
Completed No phase listed Observational

Trauma Expectation Factor Trauma Outcome Measure

NCT01126398
View directory record Official record
Conditions
Ankle Fracture, Pilon Fracture
Interventions
ankle or distal tibia surgery
Procedure
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
3
States / cities
Jacksonville, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting Not applicable Interventional

InterTAN: Integrated Dual Screw Design Improve Biomechanics/Function Following Fixation Surgery

NCT06024304
View directory record Official record
Conditions
Fracture of Hip
Interventions
Synthes TFNA, Trigen InterTAN
Device
Lead sponsor
Paul E. Matuszewski
Other
Eligibility
55 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 23, 2026, 10:45 PM EDT
Withdrawn Phase 3 Interventional

Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures

NCT03826784
View directory record Official record
Conditions
Tibial Fractures
Interventions
BHA
Combination Product
Lead sponsor
Carmell Therapeutics Corporation
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Jul 23, 2026, 10:45 PM EDT
Not listed Not applicable Interventional

Intramedullary Bone Grafting for Open Tibial Shaft Fractures

NCT03891888
View directory record Official record
Conditions
Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
Interventions
Intramedullary Bone Graft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Results available

Dalteparin in Preventing DVT in Participants With Cancer

NCT00525057
View directory record Official record
Conditions
Bone Sarcoma, Femur Fracture, Lymphoma, Metastatic Neoplasm, Pathologic Fracture, Plasma Cell Myeloma, Soft Tissue Sarcoma
Interventions
Dalteparin
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
30 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Jul 23, 2026, 10:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?

NCT05652881
View directory record Official record
Conditions
Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
Interventions
Joint Lavage
Procedure
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

Intramedullary Nail Versus Sliding Hip Screw Inter-Trochanteric Evaluation

NCT01380444
View directory record Official record
Conditions
Femoral Neck Fractures, Intertrochanteric Fracture
Interventions
Gamma3 Intramedullary Nails (Stryker), Sliding Hip Screws
Procedure
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
7
States / cities
Fresno, California • San Francisco, California • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jul 23, 2026, 10:45 PM EDT
Withdrawn Not applicable Interventional

Waterproof Casting Versus Standard Casting for Short Leg Walking Casts

NCT04961957
View directory record Official record
Conditions
Ankle Fractures, Foot Fracture, Ankle Sprains, Foot Sprain, Toe-walking, Tendonitis of Foot, Apophysitis; Juvenile
Interventions
Waterproof padding, Non-waterproof padding
Device
Lead sponsor
West Virginia University
Other
Eligibility
5 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Jul 23, 2026, 10:45 PM EDT
Completed No phase listed Observational Results available

DePuy Trochanteric (ATN) Nailing Clinical Outcomes Trial

NCT00546429
View directory record Official record
Conditions
Femoral Fracture (Proximal)
Interventions
Intramedullary nailing
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
4
States / cities
Colorado Springs, Colorado • Englewood, Colorado • Buffalo, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 23, 2026, 10:45 PM EDT
Terminated Not applicable Interventional Results available

Trial to Evaluate UltraSound in the Treatment of Tibial Fractures

NCT00667849
View directory record Official record
Conditions
Tibial Fractures
Interventions
Exogen 4000+, Sham
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
18 Years and older
Enrollment
501 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
13
States / cities
San Francisco, California • Tampa, Florida • Indianapolis, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting Not applicable Interventional

Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery

NCT05445960
View directory record Official record
Conditions
Ankle Fractures, Ankle Fracture - Lateral Malleolus, Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar, Ankle Fracture - Medial Malleolus, Maisonneuve's Fracture, Syndesmotic Injuries, Fibula Fracture
Interventions
Tourniquet
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

NCT02027896
View directory record Official record
Conditions
Hip Fractures
Interventions
Accelerated medical clearance and surgery
Other
Lead sponsor
McMaster University
Other
Eligibility
45 Years and older
Enrollment
3,001 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
5
States / cities
San Jose, California • Baltimore, Maryland • Burlington, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Phase 4 Interventional Results available

Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block

NCT01616173
View directory record Official record
Conditions
Fracture of Ankle
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting Not applicable Interventional

Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures

NCT07280169
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures

NCT05680987
View directory record Official record
Conditions
Femoral Fracture
Interventions
RFN-Advanced Retrograde Femoral Nailing System
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Jul 23, 2026, 10:45 PM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 23, 2026, 10:45 PM EDT
Withdrawn Not applicable Interventional

Blood Flow Restriction Therapy Improves Tibial Plateau Fracture Recovery

NCT06589115
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Blood Flow Restriction Cuff, Physical Therapy
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting No phase listed Observational

MDR - PMCF Study for Taperloc Complete Stems

NCT04028687
View directory record Official record
Conditions
Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries, Hip Pain Chronic
Interventions
Taperloc Complete Stem
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
820 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2032
U.S. locations
3
States / cities
Henderson, Nevada • Plano, Texas • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting Phase 4 Interventional

Single Shot Exparel vs Catheters in Lower Extremity Trauma

NCT07221019
View directory record Official record
Conditions
Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg, Fracture
Interventions
Bupivacaine, Exparel + Bupivacaine
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 23, 2026, 10:45 PM EDT
Terminated Phase 3 Interventional Results available

Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)

NCT01908751
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Sliding Hip Screw, Cancellous Screws, Vitamin D, Vitamin D Placebo
Procedure · Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years to 60 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2020 · Synced Jul 23, 2026, 10:45 PM EDT
Recruiting No phase listed Observational

Assessment of Treatment Variability for Pelvic Ring Fragility Fractures

NCT07351123
View directory record Official record
Conditions
Pelvic Fractures, Fragility Fractures of the Pelvis (FFP)
Interventions
Surgical stabilization of pelvic fracture, Closed treatment of pelvic fracture
Procedure · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 23, 2026, 10:45 PM EDT
Completed Not applicable Interventional

Early Weight Bearing on Supracondylar Distal Femur Fractures in Elderly Patients

NCT02475941
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
Non Weight bearing, Early Weight Bearing
Other
Lead sponsor
St. Louis University
Other
Eligibility
64 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
6
States / cities
Atlanta, Georgia • St Louis, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Jul 23, 2026, 10:45 PM EDT