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ClinicalTrials.gov public records Last synced Oct 29, 2026, 10:49 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 409–432 of 1,041 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Injuries Clear all
Terminated Not applicable Interventional Results available

Effectiveness of Sorbion in the Treatment of Venous Leg Ulcers The Protocol Elements

NCT03020446
View directory record Official record
Conditions
Venous Wound Ulcers
Interventions
Sorbion Dressing
Device
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 27, 2020 · Synced Oct 29, 2026, 10:49 PM EDT
Not listed Phase 3 Interventional

Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability

NCT03507803
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries
Interventions
Gait Biofeedback
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Oct 29, 2026, 10:49 PM EDT
Recruiting Phase 1 Interventional

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

NCT06639503
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Bupivacain
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional

Effect of Custom Dynamic Orthoses on Forefoot Loading

NCT06710119
View directory record Official record
Conditions
Lower Extremity Injuries
Interventions
Visual Feedback
Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Iowa City, Iowa • Everett, Washington
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional

IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities

NCT07721792
View directory record Official record
Conditions
Lower Limb Injury, Ankle Foot Orthosis (AFO), Lower Limb Trauma
Interventions
Advanced Ankle Foot Orthosis (AFO), Conventional Ankle Foot Orthosis (AFO)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Tampa, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Terminated Not applicable Interventional

ACL Bone Health and Loading Study

NCT04682392
View directory record Official record
Conditions
ACL Tear
Interventions
Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
Device · Other
Lead sponsor
Candice Dunkin, MS, LAT, ATC
Other
Eligibility
16 Years to 22 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Recruiting No phase listed Observational

Pelvic and Acetabular Fracture: A Prospective Observational Study

NCT04615104
View directory record Official record
Conditions
Pelvic Fracture, Acetabular Fracture, Pubic Rami Fracture
Interventions
Operative, Nonoperative
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

NCT03809520
View directory record Official record
Conditions
Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
Interventions
pedCAT
Radiation
Lead sponsor
J L Marsh
Other
Eligibility
18 Years to 70 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT03209531
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation
Behavioral · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Optimizing Plyometric Training for Functional Recovery Post-ACL Reconstruction

NCT02148172
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Knee Injury
Interventions
Standard Plyometric Training, Plyometric Training with BWS
Procedure
Lead sponsor
University of Montana
Other
Eligibility
12 Years to 35 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Oct 29, 2026, 10:49 PM EDT
Active, not recruiting No phase listed Observational

Real-World Effectiveness of Amniotic Membrane Allografts Versus Standard Wound Care in DFU, VLU, and PU

NCT07223281
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer
Interventions
Not listed
Lead sponsor
Legacy Medical Consultants
Industry
Eligibility
18 Years and older
Enrollment
2,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
4
States / cities
Colorado Springs, Colorado • Clinton Township, Michigan • Tulsa, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 29, 2026, 10:49 PM EDT
Completed No phase listed Observational

Predictive Models for Spine and Lower Extremity Injury After Discharge From Rehab

NCT02776930
View directory record Official record
Conditions
Musculoskeletal Injury, Spinal Injuries, Leg Injuries
Interventions
Not listed
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 45 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Fort Bragg, North Carolina • Fort Bliss, Texas • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability

NCT07237581
View directory record Official record
Conditions
Ankle Sprains, Chronic Ankle Instability
Interventions
CBPT/HEP, HEP Only
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 29, 2026, 10:49 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

SCANLOAD: The Effect of Limb Loading on Lower Limb Geometry

NCT04600102
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Structure Sensor
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome

NCT04437537
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Bioresorbable 3D electrospun synthetic matrix
Device
Lead sponsor
RenovoDerm
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Northampton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Terminated Not applicable Interventional Results available

Skilled Motor Training and tDCS to Improve Leg Function After Spinal Cord Injury

NCT01962675
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Transcranial direct current stimulation + step training, Sham transcranial direct current stimulation + step training
Device · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Early Phase 1 Interventional

Taliderm Dressing for Venous Ulcers

NCT00720239
View directory record Official record
Conditions
Venous Stasis Ulcers, Venous Insufficiency
Interventions
Taliderm wound healing dressing
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
45 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 22, 2013 · Synced Oct 29, 2026, 10:49 PM EDT
Terminated Not applicable Interventional Results available

Does Optimized General Anesthesia Care Reduce Postoperative Delirium?

NCT02604459
View directory record Official record
Conditions
Hip Fractures, Anesthesia, Delirium
Interventions
cerebral oximeter (Fore-Sight), depth of anesthesia monitor (BIS), BP management, General anesthesia, propofol, fentanyl, sevoflurane
Device · Procedure · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
65 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Oct 29, 2026, 10:49 PM EDT
Completed No phase listed Observational

Plate Fixation of Distal Femur Fractures: A Protocol for a Study of Two Plate Options

NCT00644397
View directory record Official record
Conditions
Femoral Fractures
Interventions
95-degree Angled Blade Plate, 4.5mm Condylar Locking Plate
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
16 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2019 · Synced Oct 29, 2026, 10:49 PM EDT
Not yet recruiting Not applicable Interventional

Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers

NCT07290673
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU)
Interventions
FoundationDRS Solo, Standard of Care
Other
Lead sponsor
Samaritan Biologics
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hollywood, Florida
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Terminated Not applicable Interventional

Contracture Reduction Following Bunionectomy: a Longitudinal, Controlled Trial

NCT01589679
View directory record Official record
Conditions
Hallux Limitus
Interventions
standard of care, Metarsal Dynasplint
Other · Device
Lead sponsor
Dynasplint Systems, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
3
States / cities
Boston, Massachusetts • Henderson, Nevada • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2013 · Synced Oct 29, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional

Lateral Ankle Treatment

NCT07751068
View directory record Official record
Conditions
Avulsion Fracture
Interventions
Prolonged Immobilization (Casting), Standard of Care (SOC)
Procedure
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
5 Years to 12 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2034
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 29, 2026, 10:49 PM EDT
Completed Phase 2 Interventional

Investigation of Subatmospheric Pressure Dressing on Pressure Ulcer Healing

NCT00011531
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Prevention of Pressure Ulcers
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2001
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2009 · Synced Oct 29, 2026, 10:49 PM EDT