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ClinicalTrials.gov public records Last synced Oct 25, 2026, 2:28 PM EDT

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Showing 25–48 of 1,039 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Injuries Clear all
Completed Not applicable Interventional Results available

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

NCT06071715
View directory record Official record
Conditions
Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions
ACTIVE cryoneurolysis, SHAM cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 25, 2026, 2:28 PM EDT
Recruiting No phase listed Observational

SportsPro: Post-Market Clinical Follow Up Study

NCT06320925
View directory record Official record
Conditions
Shoulder Injuries, Knee Injuries, Hip Injuries
Interventions
Standard of Care Treatment
Device
Lead sponsor
Stryker Endoscopy
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Phoenix, Arizona • Englewood, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 25, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Study of the Provant Therapy System in Subjects With Diabetic Foot Ulcers

NCT00761176
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
The Provant Therapy System
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Oct 25, 2026, 2:28 PM EDT
Recruiting Phase 4 Interventional

Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers

NCT06754735
View directory record Official record
Conditions
Venous Leg Ulcer (VLU)
Interventions
Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen
Device
Lead sponsor
AOTI Ltd.
Industry
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 25, 2026, 2:28 PM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 25, 2026, 2:28 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Safety Study of Topical Human FGF-1 for Wound Healing

NCT00916292
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
FGF-1 141
Drug
Lead sponsor
Phage Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Oct 25, 2026, 2:28 PM EDT
Completed Phase 4 Interventional Results available

Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients

NCT01904071
View directory record Official record
Conditions
Hip Fracture
Interventions
UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
Procedure · Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 25, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Spica Casting in Pediatric Femur Fractures: Study of Single Leg Versus Double Leg Spica Casts

NCT01293916
View directory record Official record
Conditions
Femur Fracture
Interventions
Spica casting
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
2 Years to 6 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 25, 2026, 2:28 PM EDT
Completed Phase 3 Interventional

Improving Functional Recovery After Hip Fracture

NCT00000436
View directory record Official record
Conditions
Unilateral Hip Fracture
Interventions
Self-efficacy and muscle strength training, High-intensity strength training
Behavioral · Procedure
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2000
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 4, 2007 · Synced Oct 25, 2026, 2:28 PM EDT
Withdrawn Not applicable Interventional

Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures

NCT05559736
View directory record Official record
Conditions
Intertrochanteric Fractures, Femoral Fracture, Femoral Neck Fractures
Interventions
Artemis Proximal Femoral Nail (PFN) implant
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 25, 2026, 2:28 PM EDT
Terminated Phase 2 Interventional

Image Guided System for Orthopaedic Surgery

NCT00022802
View directory record Official record
Conditions
Orthopaedic Trauma, Hip Fracture
Interventions
Image-guided surgical system
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Park Ridge, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 9, 2009 · Synced Oct 25, 2026, 2:28 PM EDT
Not listed No phase listed Observational

Treatment of Syndesmotic Disruption With Anatomic Distal Tibiofibular Ligament Augmentation

NCT04933045
View directory record Official record
Conditions
Syndesmotic Injuries
Interventions
Arthrex InternalBrace
Device
Lead sponsor
St. Clair Orthopaedics
Other
Eligibility
18 Years to 105 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Saint Clair Shores, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 21, 2021 · Synced Oct 25, 2026, 2:28 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers.

NCT02344329
View directory record Official record
Conditions
Diabetic Foot Ulcers, Diabetes
Interventions
Topical wound dressing, Human Amnion Allograft, usual wound care
Device · Biological · Other
Lead sponsor
University of North Dakota
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Oct 25, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Results available

Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s)

NCT03369756
View directory record Official record
Conditions
Wound of Lower Leg (Physical Finding)
Interventions
Prontosan Wound Irrigation Solution and Prontosan Wound Gel
Device
Lead sponsor
B. Braun Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
5
States / cities
Jupiter, Florida • North Miami Beach, Florida • North New Hyde Park, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Oct 25, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk

NCT06442956
View directory record Official record
Conditions
Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
Interventions
Rapid Heat Condition, Gradual Heat Condition
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 57 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 25, 2026, 2:28 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Clinical Outcome and Fusion Results Using the SiJoin® Transfixing Sacroiliac Fusion Device

NCT05712850
View directory record Official record
Conditions
Sacroiliitis, Sacroiliac Joint Dysfunction, Iatrogenic Injury, Osteitis Condensans Ilii, Pelvic Fracture
Interventions
SiJoin® Transfixing Sacroiliac Fusion Device
Procedure
Lead sponsor
VG Innovations, LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Naples, Florida
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 25, 2026, 2:28 PM EDT
Withdrawn Not applicable Interventional

Dynamic ACL Brace: In Vivo Kinematics

NCT03670550
View directory record Official record
Conditions
ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL, ACL - Anterior Cruciate Ligament Deficiency
Interventions
Ossur Rebound ACL Brace
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 25, 2026, 2:28 PM EDT
Completed No phase listed Observational

Ankle Fracture vs Ankle Fracture-Dislocation

NCT02198768
View directory record Official record
Conditions
Ankle Fractures
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 25, 2026, 2:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

BFRT in Adolescents After ACL Reconstruction

NCT04390035
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Oct 25, 2026, 2:28 PM EDT
Completed No phase listed Observational

Pilon Fracture Reduction and Functional Outcome

NCT01316289
View directory record Official record
Conditions
Pilon Fracture of Tibia
Interventions
Not listed
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Indianapolis, Indiana • Saint Paul, Minnesota • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 25, 2026, 2:28 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Comparison of Two Pain Control Techniques on Deliruim in Hip Fracture Patients

NCT01547468
View directory record Official record
Conditions
Hip Fracture
Interventions
Femoral Nerve Catheterization, Intravenous Opioids
Procedure
Lead sponsor
Leslie Thomas
Other
Eligibility
50 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2022
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Oct 25, 2026, 2:28 PM EDT
Withdrawn Phase 3 Interventional

Intravenous Acetaminophen as Adjuvant Therapy for Pain Control in Geriatric Hip Fracture Patients

NCT01520298
View directory record Official record
Conditions
Pain, Hip Fracture
Interventions
Placebo, Acetaminophen IV
Drug
Lead sponsor
Lancaster General Hospital
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 30, 2014 · Synced Oct 25, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy as a Drug Delivery System

NCT02463487
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Cardinal Pro +Simultaneous Irrigation (NPWTi), Cardinal Pro (NPWT) Therapy
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 25, 2026, 2:28 PM EDT
Recruiting Not applicable Interventional

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

NCT04999904
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 25, 2026, 2:28 PM EDT