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ClinicalTrials.gov public records Last synced Oct 30, 2026, 2:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 481–504 of 1,041 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Injuries Clear all
Completed Early Phase 1 Interventional

Taliderm Dressing for Venous Ulcers

NCT00720239
View directory record Official record
Conditions
Venous Stasis Ulcers, Venous Insufficiency
Interventions
Taliderm wound healing dressing
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
45 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 22, 2013 · Synced Oct 30, 2026, 2:19 PM EDT
Terminated Not applicable Interventional

Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

NCT06455475
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Derm-Maxx
Other
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
11
States / cities
Athens, Alabama • Encino, California • Hollywood, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Completed No phase listed Observational

Primary Urethral Realignment Versus Suprapubic Cystostomy After Pelvic Fracture Urethral Injury

NCT03195179
View directory record Official record
Conditions
Pelvic Fracture, Urethra Tear, Urethra Injury Male, Trauma, Surgery
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Timeline
2016 – 2021
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach

NCT03273673
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Biofeedback Intervention
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
14 Years to 21 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 4, 2020 · Synced Oct 30, 2026, 2:19 PM EDT
Not listed Not applicable Interventional

Effects of Tranexamic Acid on Blood Loss and Transfusion Requirement Following Hip Fracture

NCT02738073
View directory record Official record
Conditions
Hip Fracture
Interventions
Control: Saline, Tranexamic Acid
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Bryn Mawr, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Oct 30, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional

Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures

NCT07280169
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Fascia Iliaca Block in Hip Fracture Patients

NCT03525977
View directory record Official record
Conditions
Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures)
Interventions
Fascia iliaca block arm
Procedure
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 99 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 28, 2019 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Lower-Limb Exoskeleton Technology for Non-Ambulatory Individuals With Spinal Cord Injury

NCT07128901
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Ekso Indego Therapy, Wandercraft Atalante X
Device
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional

DermACELL AWM® in Chronic Wagner Grade 3/4 Diabetic Foot Ulcers

NCT03044132
View directory record Official record
Conditions
Diabetic Foot Ulcer, Lower Extremity Wound
Interventions
DermACELL AWM
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
21 Years to 85 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Fresno, California • Rocky Mount, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 24, 2010 · Synced Oct 30, 2026, 2:19 PM EDT
Completed No phase listed Observational

Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a Protocol for Early Appropriate Care

NCT00888160
View directory record Official record
Conditions
Unstable Pelvic Ring Fracture, Unstable Acetabulum Fracture, Femur Fracture
Interventions
Not listed
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
16 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2031
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Oct 30, 2026, 2:19 PM EDT
Terminated Not applicable Interventional

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

NCT04537013
View directory record Official record
Conditions
Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
Interventions
Microfracture, Microfracture plus placement of Chondro-Gide® ACC
Procedure · Device
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acute Effects of Neurodynamics on Strength and Endurance in Athletes

NCT07721220
View directory record Official record
Conditions
Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength, Hamstring Injuries, Hamstring Injury Prevention, Hamstring Rupture, Sciatic Nerve Injury, Sciatic Radiculopathy, Lumbar Disc Herniation With Radiculopathy, Lumbar Disc Herniation
Interventions
Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss, Elastic Resistance Band
Other · Device
Lead sponsor
High Point University
Other
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional

A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

NCT05588583
View directory record Official record
Conditions
Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Mepilex Up
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Castro Valley, California • Los Angeles, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 30, 2026, 2:19 PM EDT
Active, not recruiting Not applicable Interventional

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

NCT03776162
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
Procedure · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boulder, Colorado • Bloomington, Minnesota • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional

Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care

NCT06939673
View directory record Official record
Conditions
Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs), Pressure Ulcers, Surgical Wound Dehiscence (SWD), Chronic Wounds, Undermined and Tunneling Wounds
Interventions
Acellular Porcine-Derived Wound Matrix
Device
Lead sponsor
Reprise Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Coconut Creek, Florida • Tamarac, Florida
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

NCT00985842
View directory record Official record
Conditions
Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions
Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 29, 2018 · Synced Oct 30, 2026, 2:19 PM EDT
Completed No phase listed Observational

Sport Cord Test Following ACL Reconstruction

NCT01937403
View directory record Official record
Conditions
Injury of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
The Hawkins Foundation
Other
Eligibility
10 Years to 50 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 30, 2026, 2:19 PM EDT
Completed No phase listed Observational

Pediatric Locking Nail for the Treatment of Femoral Fractures in Children

NCT00725894
View directory record Official record
Conditions
Femur Fracture
Interventions
Pediatric Locking Nail
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
8 Years to 16 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
3
States / cities
Phoenix, Arizona • Orlando, Florida • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Oct 30, 2026, 2:19 PM EDT
Active, not recruiting Not applicable Interventional

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population

NCT04784429
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions
Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
65 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
90
States / cities
Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Phase 4 Interventional Results available

Are Opioids Needed After ACL Reconstruction

NCT04285853
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Oxycodone, Placebo oral tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
14 Years to 40 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia • Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Oct 30, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional

Simplified Post Op Rehabilitation for Ankle and Pilon Fractures

NCT05280639
View directory record Official record
Conditions
Ankle Fractures, Pilon Fracture
Interventions
Wooden block, Formal physical therapy or Home Exercise Program
Device · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 30, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

Multimodal Exercises to Improve Leg Function After Spinal Cord Injury

NCT01740128
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Paraparesis
Interventions
Robotic body weight supported treadmill training, Harness-supported multimodal balance training
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 30, 2026, 2:19 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Tele-Exercise Platform for Plantar Wound Healing

NCT06439667
View directory record Official record
Conditions
Diabetic Foot Ulcer, Wound Healing, Wound Care
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 30, 2026, 2:19 PM EDT