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Conditions: Arterial Occlusive Diseases
Interventions: alfimeprase; Drug
Lead sponsor: ARCA Biopharma, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Lower Extremity Occlusive Disease
Interventions: Computer assisted surgery; Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Chicago, Illinois

Conditions: Peripheral Artery Disease, Clopidogrel, Poor Metabolism of, Peripheral Vascular Disease, Artery Disease, Peripheral Arterial Occlusive Disease
Interventions: Point of care screening for HPR, Ticagrelor 90mg; Diagnostic Test · Drug
Lead sponsor: Marissa Jarosinski; Other
Eligibility: 18 Years to 90 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Critical Limb Ischemia
Interventions: treprostinil dienthanolmine sustained release, Placebo; Drug
Lead sponsor: Ochsner Health System; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Critical Limb Ischemia
Interventions: VM202 2 mg, VM202 4 mg, VM202 8 mg, VM202 16 mg; Biological
Lead sponsor: Helixmith Co., Ltd.; Industry
Eligibility: 20 Years to 90 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Peripheral Arterial Disease, Peripheral Artery Disease
Interventions: FRAME; Device
Lead sponsor: Vascular Graft Solutions Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 3
States / cities: Fort Wayne, Indiana • Baltimore, Maryland • New York, New York

Conditions: Peripheral Arterial Disease
Interventions: Clopidogrel (Plavix) Pharmacogenetic Test Reagents; Drug
Lead sponsor: Corewell Health West; Other
Eligibility: 45 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Detroit, Michigan • Grand Rapids, Michigan

Conditions: Peripheral Arterial Disease
Interventions: Ranolazine, Placebo; Drug
Lead sponsor: Corewell Health East; Other
Eligibility: 40 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Intermittent Claudication, Arteriosclerosis
Interventions: DNA Plasmid Vector, EW-A-401 DNA Plasmid Vector; Drug
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 21 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2011
U.S. locations: 3
States / cities: Birmingham, Alabama • Bethesda, Maryland • Madison, Wisconsin

Conditions: Peripheral Vascular Disease
Interventions: Liprostin [liposomal Prostaglandin E1]; Drug
Lead sponsor: Endovasc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Intermittent Claudication, Ischemia Vascular, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions: Ischemic Preconditioning, Control Group; Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years to 80 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Diabetic Foot Ulcer, Peripheral Arterial Disease, Wound; Foot
Interventions: VibratoSleeve Therapeutic Ultrasound Device; Device
Lead sponsor: Vibrato Medical, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Orange, California

Conditions: Peripheral Arterial Disease, Peripheral Artery Disease
Interventions: MitoQ; Dietary Supplement
Lead sponsor: University of Nebraska; Other
Eligibility: 50 Years to 85 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions: Bone marrow concentration device, Placebo procedure (sham); Device · Procedure
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 21 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2020
U.S. locations: 25
States / cities: Little Rock, Arkansas • Sacramento, California • Miami, Florida + 20 more

Conditions: Chronic Limb Threatening Ischemia
Interventions: Transverse Tibial Bone Transport, TrueLok Elevate; Procedure · Device
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 95 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Superficial Femoral Artery Stenosis, Superficial Femoral Artery Occlusion, Claudication, Rest Pain
Interventions: Open Bypass Surgery, Angioplasty and Stenting; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Peripheral Arterial Disease
Interventions: Atherectomy; Device
Lead sponsor: Ra Medical Systems; Industry
Eligibility: 22 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 10
States / cities: El Centro, California • Merced, California • Gainesville, Florida + 7 more

Conditions: Peripheral Artery Disease
Interventions: Contrast Injection, Dextran Injection, CO2 Injection, Heparinized Normal Saline Injection; Procedure
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Critical Limb Ischemia, Critical Lower Limb Ischemia, Peripheral Artery Disease, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Arterial Occlusive Diseases, Arterial Occlusion, Arterial Disease, Peripheral Artery Occlusion, Peripheral Vascular Disease, Peripheral Ischemia, Vascular Diseases
Interventions: LimFlow System; Device
Lead sponsor: LimFlow, Inc.; Industry
Eligibility: 18 Years to 95 Years
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 20
States / cities: San Francisco, California • Torrance, California • New Haven, Connecticut + 15 more

Conditions: Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
Interventions: Error-augmentation gait training, Error-correction gait training, Supervised walking; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 89 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 2
States / cities: Aurora, Colorado • Richmond, Virginia

Conditions: Wound Heal, Peripheral Artery Disease, Ulcer, Leg, Ulcer Foot, Diabetic Foot Ulcer, Arterial Insufficiency
Interventions: Noxsano Bandage (Healthy Volunteers), Noxsano Bandage (Wound Care); Device
Lead sponsor: OhioHealth; Other
Eligibility: 18 Years to 79 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Peripheral Artery Disease (PAD)
Interventions: REGN7508, REGN9933, Placebo, Rivaroxaban; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 7,050 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 4
States / cities: Crystal River, Florida • Amarillo, Texas • DeSoto, Texas + 1 more

Conditions: Peripheral Vascular Diseases
Interventions: NightHawk; Device
Lead sponsor: FoxHollow Technologies; Industry
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Chronic Critical Limb Ischemia, Peripheral Vascular Diseases
Interventions: Xpert(TM) Self-expanding Transhepatic Biliary Stent System feasibility in treating chronic critical limb ischemia; Device
Lead sponsor: VIVA Physicians; Other
Eligibility: 18 Years to 89 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: San Jose, California

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Study of Alfimeprase's Ability to Dissolve Blood Clots in the Leg and Help Prevent the Need for Surgery

Safety and Efficacy of Computer Assisted Surgery for Use in Vascular Surgery Procedures

The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions

Safety Study of UT-15C SR (Oral Treprostinil) in Patients Undergoing a Lower Limb Endovascular Procedure

Safety Study of Gene Therapy in Treating Critical Leg Ischemia

FRAME, External Support for Lower Limb Autologous Grafts

Vascular Trial Associated Registry Pilot

Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities

EW-A-401 to Treat Intermittent Claudication

Prostaglandin E1 (Liprostin) Treatment With Lower Limb Angioplasty for Peripheral Arterial Occlusive Disease

Ischemic Preconditioning Claudication Study

A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers.

Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients

Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)

Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI)

Revascularization With Open Bypass Versus Angioplasty and STenting of the Lower Extremity Trial (ROBUST)

A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages

Optical Imaging Measurement of Intravascular Solution Efficacy Trial

PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

Safety and Efficacy of the Noxsano Wound Care Bandage

Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease

A Non-Randomized Study of the NightHawk Peripheral Plaque Excision System During Plaque Excision of Peripheral Arterial Disease

Study to Evaluate the Safety & Performance of the Xpert(TM) Stent in Treating Below-the-knee Lesions in Patients Undergoing Percutaneous Intervention for Chronic CLI.