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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Extremity Paresis Clear all
Completed Not applicable Interventional Results available

Clinical Trial Comparing C-Brace to Knee Ankle Foot Orthosis (KAFO)/Stance Control Orthosis (SCO)

NCT03906656
View directory record Official record
Conditions
Pareses, Lower Extremity
Interventions
C-Brace, KAFO/SCO
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
4
States / cities
Sarasota, Florida • Chicago, Illinois • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 22, 2026, 1:20 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults

NCT04437251
View directory record Official record
Conditions
Vascular Accident, Brain, CVA (Cerebrovascular Accident), Gait, Hemiplegic, Spastic Lower Extremity Weakness
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
Texas Woman's University
Other
Eligibility
21 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Jul 22, 2026, 1:20 AM EDT
Not listed Phase 1Phase 2 Interventional

AMES Treatment of the Impaired Leg in Chronic Stroke Patients

NCT01378637
View directory record Official record
Conditions
Stroke, Cerebrovascular Accident, Hemiparesis
Interventions
AMES- Leg treatment
Device
Lead sponsor
AMES Technology
Industry
Eligibility
18 Years to 85 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Jul 22, 2026, 1:20 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Human-Machine System for the H2 Lower Limb Exoskeleton

NCT02114450
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
Robot-assisted training with the H2 lower limb powered exoskeleton, Supervised motor practice
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2029
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Jul 22, 2026, 1:20 AM EDT
Recruiting No phase listed Observational

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

NCT06998134
View directory record Official record
Conditions
Muscle Weakness, Problems Moving Their Arms and Legs
Interventions
Extension assist knee ankle foot orthosis (EA-KAFO)
Device
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
5 Years to 25 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional

Neuromuscular and Biomechanical Control of Lower Limb Loading in Individuals With Chronic Stroke

NCT03694028
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
Limb Loading, Conventional Training
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Multimodal Exercises to Improve Leg Function After Spinal Cord Injury

NCT01740128
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Paraparesis
Interventions
Robotic body weight supported treadmill training, Harness-supported multimodal balance training
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Jul 22, 2026, 1:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Use of Hand-held Dynamometry to Obtain Objective Measures of Lower Extremity Force Production With Chronic Stroke

NCT05941962
View directory record Official record
Conditions
Chronic Stroke, Weakness, Muscle
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jul 22, 2026, 1:20 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

HIFEM and Radiofrequency for Muscular System Function Improvement

NCT06703749
View directory record Official record
Conditions
Muscle Damage, Muscle Strength, Muscle Weakness
Interventions
Treatment with BTL-899M, Treatment with BTL-899M with intensities below therapeutic threshold
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Scottsdale, Arizona • Greenwood Village, Colorado • Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors

NCT01029912
View directory record Official record
Conditions
Stroke, Hemiparesis, Lower Extremity Paresis
Interventions
Electrical stimulator
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Jul 22, 2026, 1:20 AM EDT
Not listed Not applicable Interventional

Evaluation of the Effectiveness and Safety of Keeogo™ Dermoskeleton in Subjects With Mobility Impairments Due to Stroke

NCT03986320
View directory record Official record
Conditions
Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Hemiparesis, Cerebral Vascular Accident
Interventions
Keeogo™ Dermoskeleton
Device
Lead sponsor
B-Temia, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Chicago, Illinois • West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 28, 2019 · Synced Jul 22, 2026, 1:20 AM EDT
Recruiting Not applicable Interventional

Biomarkers of Reaction To HIIT Exercise

NCT06059872
View directory record Official record
Conditions
Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty
Interventions
High Intensity Interval Training (HIIT)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional

BFRT for Severe Lower Extremity Muscle Atrophy

NCT04357184
View directory record Official record
Conditions
Severe Muscle Atrophy, Muscle Weakness
Interventions
Blood flow restriction training
Other
Lead sponsor
Cincinnati Sportsmedicine Research and Education Foundation
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sideways Treadmill Training to Improve Paretic Leg Stepping in Persons Post-Stroke

NCT02516176
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
treadmill training
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional

Constraint-induced Movement Therapy to Improve Gait and Mobility of People With Chronic Stroke

NCT03114046
View directory record Official record
Conditions
Rehabilitation, Recovery of Function, Stroke, Lower Extremity Paresis
Interventions
Lower extremity Constraint-induced movement therapy(LE-CIMT)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate Lower Extremity Sleeve and Pump Device to Treat Hemiparesis

NCT05535257
View directory record Official record
Conditions
Upper Extremity Weakness, Stroke
Interventions
Sequential Compression Device
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Saint Johns, Florida
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Powered Orthotic Exoskeleton Training in Stroke

NCT04241848
View directory record Official record
Conditions
Stroke
Interventions
Keeogo, Ambulation training
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short Term Immobilization of the Lower Limb

NCT05072652
View directory record Official record
Conditions
Weakness, Muscle, Muscle Weakness, Muscle Loss, Muscle Atrophy, Injury, Knee
Interventions
Neuromuscular Electrical Stimulation, Action Observation + Mental Imagery
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Jul 22, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke

NCT02199795
View directory record Official record
Conditions
Stroke, Hemiparesis, Footdrop
Interventions
Contralaterally Controlled Neuromuscular Electrical Stimulation, Cyclic Neuromuscular Electrical Stimulation
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Jul 22, 2026, 1:20 AM EDT
Not yet recruiting Not applicable Interventional

Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors

NCT07250425
View directory record Official record
Conditions
Stroke, Neurological Diseases or Conditions, Hemiparesis;Poststroke/CVA, Gait Disorders, Neurologic, Post Stroke Fatigue, Motor Recovery, Walking Difficulty, Balance Impairment, Falls Prevention, Hemiparesis, Mobility Limitation
Interventions
Rise&Walk InHome by Healing Innovations
Device
Lead sponsor
Healing Innovations
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jul 22, 2026, 1:20 AM EDT
Recruiting No phase listed Observational

C-Brace Prospective Registry

NCT04640584
View directory record Official record
Conditions
Pareses, Lower Extremity
Interventions
C-Brace
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
70
States / cities
Harrison, Arkansas • Rogers, Arkansas • San Diego, California + 63 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Jul 22, 2026, 1:20 AM EDT