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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:10 AM EDT

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Showing 1–24 of 168 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Surgery Clear all
Recruiting Phase 4 Interventional

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

NCT03858231
View directory record Official record
Conditions
Knee Injuries, Pain, Postoperative, Opioid Use
Interventions
Norco 5Mg-325Mg Tablet, Ibuprofen 600 mg, Acetaminophen 325Mg Tab
Drug
Lead sponsor
Sanford Health
Other
Eligibility
18 Years to 80 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Not applicable Interventional

A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

NCT06979804
View directory record Official record
Conditions
ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
Interventions
Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
Device
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
16 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Not applicable Interventional

Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

NCT05526417
View directory record Official record
Conditions
Soft Tissue Sarcoma, Stage I Soft Tissue Sarcoma of the Trunk and Extremities, Stage II Soft Tissue Sarcoma of the Trunk and Extremities, Stage III Soft Tissue Sarcoma of the Trunk and Extremities
Interventions
Computed Tomography, Educational Intervention, Magnetic Resonance Imaging, Physical Therapy, Questionnaire Administration, Telemedicine
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

NCT01053572
View directory record Official record
Conditions
Low Back Pain
Interventions
Adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 18, 2026, 2:10 AM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Withdrawn No phase listed Observational

Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients

NCT03787862
View directory record Official record
Conditions
Foot Ulcers, Osteomyelitis, Amputation
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 26, 2018 · Synced Oct 18, 2026, 2:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Muscle Function After Ankle Surgery

NCT00060970
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness, Fractures
Interventions
Physical Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 18, 2026, 2:10 AM EDT
Enrolling by invitation Phase 3 Interventional

Reduce Opiate Exposure With ACL Surgery

NCT06561035
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Opiate Sparing, Opiate Based
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 85 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Skokie, Illinois • Cincinnati, Ohio • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Crutch Use After Arthroscopic Hip Surgery

NCT04070430
View directory record Official record
Conditions
Hip Fractures, Hip Injuries
Interventions
2 weeks of partial weight bearing on crutches, 4 weeks of partial weight bearing on crutches
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2021 · Synced Oct 18, 2026, 2:10 AM EDT
Terminated Not applicable Interventional Results available

Blood Flow Restriction Training in ACL Surgery

NCT05245864
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
blood flow restriction, physical therapy standard of care
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 34 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Phase 3 Interventional

Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery

NCT00412035
View directory record Official record
Conditions
Unequal Length of Limbs; Congenital, Lower Extremity Deformities, Congenital
Interventions
Botulinum toxin A injection, saline injection
Drug
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
5 Years to 21 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
4
States / cities
Wilmington, Delaware • Honolulu, Hawaii • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Phase 4 Interventional

Clinical Trial of a Silver Eluting Dressing System

NCT01229358
View directory record Official record
Conditions
Vascular Disease, Surgery
Interventions
Surgical dressing
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Oct 18, 2026, 2:10 AM EDT
Withdrawn Phase 1Phase 2 Interventional

A Study of Postsurgical Pain Control for Lower Extremity Fractures

NCT02214810
View directory record Official record
Conditions
Lower Extremity Fractures.
Interventions
Bupivacaine/Exparel
Drug
Lead sponsor
Broward Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 19, 2016 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery

NCT02997644
View directory record Official record
Conditions
Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
Interventions
Video Education, Usual Care Group
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 18, 2026, 2:10 AM EDT
Not listed No phase listed Observational

Clinical Outcome Following Arthroscopic Knee Surgery

NCT03700996
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
10 Years to 70 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Results available

SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery

NCT04676022
View directory record Official record
Conditions
Chronic Pain
Interventions
WaveWriter, Conventional Medical Managament
Device · Other
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
22 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
23
States / cities
Palm Desert, California • Santa Rosa, California • Greenwood Village, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lower Tourniquet Pressure Study

NCT04994405
View directory record Official record
Conditions
Hand Injuries, Upper Extremity Injury
Interventions
Tourniquet Pressure
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
3
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Oct 18, 2026, 2:10 AM EDT
Terminated Not applicable Interventional Results available

Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention

NCT02383056
View directory record Official record
Conditions
Wound
Interventions
Omnilux, Omnilux Sham
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Post-operative Lite Run Study

NCT03135145
View directory record Official record
Conditions
Cerebral Palsy, Neurologic Disorder, Chromosome Abnormality, Spina Bifida
Interventions
Lite Run Gait Trainer, Usual Treatments
Device · Other
Lead sponsor
Gillette Children's Specialty Healthcare
Other
Eligibility
4 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Phase 4 Interventional

Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults

NCT07217626
View directory record Official record
Conditions
Lower Extremity Fracture, Surgical Fracture Repair, Orthopaedic Trauma, Orthogeriatric Fractures
Interventions
Local anesthesia injections
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Not applicable Interventional

Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds

NCT07444593
View directory record Official record
Conditions
Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb
Interventions
Biodynamik XT3
Device
Lead sponsor
Biodynamik, Inc
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Not listed Not applicable Interventional

Tranexamic Acid in Orthopaedic Trauma Surgery

NCT02080494
View directory record Official record
Conditions
Blood Loss, Trauma, Fracture, Surgery
Interventions
Tranexamic Acid
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Oct 18, 2026, 2:10 AM EDT
Active, not recruiting Phase 3 Interventional

Dronabinol After Arthroscopic Surgery

NCT05335252
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Meniscus Tear, Synovitis of Knee, Knee Ligament Injury, Chondral Injury of Left Knee, Chondral Injury of Right Knee, Loose Body Knee
Interventions
Dronabinol, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications

NCT03773575
View directory record Official record
Conditions
Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma, Wound Infection, Surgical, Lymph Leakage
Interventions
PREVENA™ PEEL & PLACE™ Dressing Kit
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Valhalla, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 18, 2026, 2:10 AM EDT