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Showing 1–24 of 2,047 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Limb Clear all
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Phase 2 Interventional Results available

Polestriding Versus Walking for Subjects With Poor Leg Circulation

NCT00719355
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Walking with poles, Walking exercise
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 11, 2013 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Robotic Harvest of the Latissimus Dorsi (LD) Muscles

NCT02274493
View directory record Official record
Conditions
Other Reconstructive Surgery, Failure of Muscle Graft, Cancer, Complications, Surgical Procedure, Unspecified
Interventions
da Vinci® Robotic Surgical System, LD muscle flap harvest procedure, Reconstructive surgery, Questionnaires
Device · Procedure · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional

Use Of Gigstride Device In Patients With Lower Extremity Deficit

NCT06548087
View directory record Official record
Conditions
Ambulation Difficulty, Lower Extremity Problem
Interventions
Gigstride Ambulatory Device
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 6, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

NCT05845021
View directory record Official record
Conditions
Osteoporosis, Arthroplasty Complications, Fragility Fracture
Interventions
Surgeon-Initiated Bone Health Referral Pathway
Combination Product
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 6, 2026, 2:30 PM EDT
Active, not recruiting Not applicable Interventional

The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture

NCT04809714
View directory record Official record
Conditions
Hip Fractures, Muscle Atrophy
Interventions
Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 6, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional

Cervical Myelopathy in Hip Fracture Patients

NCT06893406
View directory record Official record
Conditions
Cervical Myelopathy, Hip Fractures
Interventions
Cervical MRI, History & Physical Exam
Diagnostic Test · Other
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Fishers, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 6, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

NCT05929508
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Ischemic Preconditioning
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Sep 6, 2026, 2:30 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease

NCT06389149
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Peripheral Artery Occlusive Disease, Peripheral Artery Disease
Interventions
LEAP therapy, no LEAP therapy
Other
Lead sponsor
University of Nebraska
Other
Eligibility
55 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Phase 4 Interventional

GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers

NCT02675855
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
GrafixPRIME®, Dressing Application, Off-loading (walking boot)
Other · Procedure · Device
Lead sponsor
Osiris Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Arizona City, Arizona • California City, California • New Mexico, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 16, 2017 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

NCT07159490
View directory record Official record
Conditions
Amputation, Prosthesis User
Interventions
Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot
Device
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 6, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation

NCT07206797
View directory record Official record
Conditions
Neuromodulatory Effects of TSCS and FES in Lower Limbs
Interventions
Functional Electrical Stimulation, Transcutaneous (Non-Invasive) Spinal Cord Stimulation, Ultrasound
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 6, 2026, 2:30 PM EDT
Not listed No phase listed Observational

Patient Empowerment Study

NCT04537676
View directory record Official record
Conditions
Diabetic Foot, Quality of Life, Mental Health Wellness 1, Ulcer Foot, Diabetes Complications
Interventions
No intervention, this is an observational study
Other
Lead sponsor
Podimetrics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Sep 6, 2026, 2:30 PM EDT
Withdrawn Not applicable Interventional

A Clinical Study to Assess a Compression Device in Patients With Venous Leg Ulcers

NCT02561013
View directory record Official record
Conditions
Varicose Ulcer
Interventions
3M™ Coban™ Custom Fit Compression System, Profore
Device
Lead sponsor
3M
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Montgomery, Alabama • Saint Paul, Minnesota • Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional

Suprapatellar Versus Infrapatellar Nailing in Tibial Fractures: A Pilot Study

NCT01341418
View directory record Official record
Conditions
Tibial Fractures
Interventions
Suprapatellar approach, Infrapatellar approach
Procedure
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 13, 2017 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Phase 4 Interventional

Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers

NCT01596920
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Tissue, Control
Other
Lead sponsor
Osiris Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
15
States / cities
Montgomery, Alabama • Glendale, Arizona • Encinitas, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Phase 4 Interventional Results available

Study of Oasis Ultra in Diabetic Foot Ulcers

NCT01835379
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Oasis, Standard
Device · Other
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
16
States / cities
Little Rock, Arkansas • Carlsbad, California • Fair Oaks, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2015 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia

NCT02190903
View directory record Official record
Conditions
Postoperative Complications, Hip Fracture, Delirium
Interventions
General endotracheal anesthesia, Regional (spinal) Anesthesia
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 29, 2018 · Synced Sep 6, 2026, 2:30 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Two Time a Week vs. Five Time a Week Blood Flow Restriction Training Program for the Lower Extremity.

NCT05342909
View directory record Official record
Conditions
Blood Flow Restriction Training
Interventions
5x a week BFR training group, 2x a week BFR training group
Other
Lead sponsor
George Fox University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Newberg, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Not applicable Interventional

Matrion™ Decellularized Placental Membrane in Subjects With Diabetic Foot Ulcers

NCT05087758
View directory record Official record
Conditions
Diabetic Foot, Lower Extremity Wound
Interventions
Matrion, Conventional Care Wound Management
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
21 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
8
States / cities
Tucson, Arizona • Carmichael, California • Fresno, California + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 6, 2026, 2:30 PM EDT
Terminated Phase 4 Interventional Results available

Pain Control in Elderly Hip Fracture Patients: Is Intravenous Acetaminophen Superior to Oral Administration?

NCT02774148
View directory record Official record
Conditions
Hip Fracture
Interventions
IV Acetaminophen, PO Acetaminophen
Drug
Lead sponsor
Corewell Health West
Other
Eligibility
65 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 6, 2026, 2:30 PM EDT
Terminated Phase 3 Interventional Results available

Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer

NCT00577317
View directory record Official record
Conditions
Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer, Stage I Uterine Corpus Cancer, Stage I Vulvar Cancer, Stage IA Cervical Cancer, Stage IB Cervical Cancer, Stage II Uterine Corpus Cancer, Stage II Vulvar Cancer, Stage IIA Cervical Cancer, Stage IIB Cervical Cancer, Stage III Cervical Cancer, Stage III Uterine Corpus Cancer, Stage III Vulvar Cancer, Stage IV Uterine Corpus Cancer, Stage IVA Cervical Cancer, Stage IVB Cervical Cancer, Stage IVB Vulvar Cancer
Interventions
Management of Therapy Complications, Quality-of-Life Assessment
Procedure · Other
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 6, 2026, 2:30 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow

NCT05087108
View directory record Official record
Conditions
Venous Thromboses, Venous Stasis
Interventions
OsciPulse system, Reference Therapy 1, Refence Therapy 2
Device
Lead sponsor
OsciFlex LLC
Industry
Eligibility
40 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 6, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional

Comparing Outcomes and Complications Following Mastisol Application for Clubfoot Casting

NCT07154550
View directory record Official record
Conditions
Club Foot
Interventions
Mastisol
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
0 Weeks to 12 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 6, 2026, 2:30 PM EDT