Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 9, 2026, 7:21 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Limb Injury
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 4
States / cities: San Diego, California • Bethesda, Maryland • Rochester, Minnesota + 1 more

Conditions: Phantom Limb Pain
Interventions: Graded motor imagery mobile app; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Amputation; Traumatic, Leg, Lower
Interventions: Tap dance program; Other
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
Interventions: C leg compared to subject's mechanical leg (Otto Bock); Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Critical Limb Ischemia
Interventions: Open surgical revascularization, Endovascular revascularization; Procedure · Device
Lead sponsor: Carelon Research; Other
Eligibility: 18 Years and older
Enrollment: 1,843 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2022
U.S. locations: 144
States / cities: Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 102 more

Conditions: Lower Limb Amputation Below Knee (Injury), Diurnal Residual Limb Fluid Volume Fluctuation
Interventions: Auto Adjusting Prosthesis; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation
Interventions: e-OPRA Implant System; Device
Lead sponsor: Integrum; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Amputation, Amputation; Traumatic, Leg, Lower
Interventions: Laminated Socket, Quatro, Infinite Socket, CJ Socket; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Chicago, Illinois • Ann Arbor, Michigan

Conditions: Amputation
Interventions: META-Arc foot locked, META-Arc foot unlocked; Device
Lead sponsor: University of Washington; Other
Eligibility: 16 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington

Conditions: Transfemoral Amputation
Interventions: RISE guided personalization of prosthetic legs by tuning experts, RISE guided personalization of prosthetic legs by prosthetists, Manual personalization of the prosthetic leg by tuning experts; Device
Lead sponsor: North Carolina State University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions: cryoablation; Device
Lead sponsor: AtriCure, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 9
States / cities: Jacksonville, Florida • Pittsfield, Massachusetts • Manchester, New Hampshire + 5 more

Conditions: Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions: Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator; Procedure
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Phantom Limb Pain
Interventions: Mr. MAPP; Device
Lead sponsor: Dallas VA Medical Center; Federal
Eligibility: Not listed
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Amputation of Lower Limb Below Knee
Interventions: Commercially-available energy storage and return prosthetic foot, MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet; Drug · Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Limb Amputation, Extremity Amputation
Interventions: Limb transplantation; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Critical Limb Ischemia
Interventions: Liposuction, Stem Cell Injection; Procedure · Other
Lead sponsor: Ageless Regenerative Institute; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Lower Limb Amputation Below Knee
Interventions: As-prescribed stiffness, Two categories stiffer than the as-prescribed stiffness, Two categories less stiff than the as-prescribed stiffness; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 70 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Lower Limb Amputation
Interventions: Active vacuum test prosthesis; Device
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Phantom Pain
Interventions: Pregabalin, Ketamine, Placebo; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 2
States / cities: Dallas, Texas

Conditions: Lower Limb Amputation
Interventions: Comprehensive assessment of walking patterns and functional mobility, Comprehensive assessment of eye movements during walking, Questionnaire Assessments completed; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Amputation
Interventions: RECOVER Prosthetic Ankle-Feet System; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
Interventions: Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis; Device
Lead sponsor: VA Eastern Colorado Health Care System; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Adjustable socket; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Search by objective public record fields.

Improved Training Program for Fall Prevention of War Fighters

Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations

Tap Dance for Adults With Lower Limb Amputation

Functional Outcomes in Dysvascular Transfemoral Amputees

Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

e-OPRA Implant System for Lower Limb Amputees

A Comparative Assessment of Transfemoral Prosthetic Sockets

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation

Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility

Influence of Socket Volume on Prosthesis Performance

Vascularized Composite Allotransplantation for Multiple Extremity Amputations

Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health

Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain

The Role of Visual Attention and Environmental Complexity in Real-world Mobility for People With Lower Limb Amputation

Impact of Improving Footwear Options

What is the Optimal Stiffness and Height of a Running-specific Prosthesis?

Auto Control of Volume Management for Limb Loss